Dr. Anna JX. Zhang

 

PhD

 

Scientific Officer, Department of Microbiology


 

Email: zhangajx@hku.hk

 

ORCID : https://orcid.org/0000-0002-5087-3614

 

 

Research Interests:

· Pathogenesis of viral pathogens in human and animal model
· Antiviral therapy for influenza virus infection

· Vaccine and vaccine adjuvant for influenza and coronaviruses

 

Updated publication list

Zhang AJ, Andrew Chak-Yiu Lee, Jasper Fuk-Woo Chan, Feifei Liu, Can Li, Yanxia Chen, Hin Chu, Siu-Ying Lau, Pui Wang, Chris Chung-Sing Chan, Vincent Kwok-Man Poon, Shuofeng Yuan, Kelvin Kai-Wang To, Honglin Chen, Kwok-Yung Yuen. Co-infection by severe acute respiratory syndrome coronavirus 2 and influenza virus enhances the severity of pneumonia in golden Syrian hamsters . Clinical Infectious Diseases, 20 December 2020

Zhang AJ, Lee AC, Chu H, Chan JF, Fan Z, Li C, Liu F, Chen Y, Yuan S, Poon VK, Chan CC, Cai JP, Wu KL, Sridhar S, Chan YS, Yuen KY. SARS-CoV-2 infects and damages the mature and immature olfactory sensory neurons of hamsters. Clin Infect Dis. 2020 Jul 15:ciaa995. doi: 10.1093/cid/ciaa995. Online ahead of print.

Chan JF, Zhang AJ, Yuan S, Poon VK, Chan CC, Lee AC, Chan WM, Fan Z, Tsoi HW, Wen L, Liang R, Cao J, Chen Y, Tang K, Luo C, Cai JP, Kok KH, Chu H, Chan KH, Sridhar S, Chen Z, Chen H, To KK, Yuen KY. Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility. Clin Infect Dis. 2020 Mar 26:ciaa325. doi: 10.1093/cid/ciaa325. Online ahead of print. PMID: 32215622 Free PMC article.

Lee ACY, Zhang AJX, Chu H, Li C, Zhu H, Mak WWN, Chen Y, Kok KH, To KKW, Yuen KY. H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses. Cell Death Dis. 2019 Jun 5;10(6):442. doi: 10.1038/s41419-019-1684-0. PMID: 31165725

Zhang AJX, Zhu H, Chen Y, Li C, Li C, Chu H, Gozali L, Lee ACY, To KKW, Hung IFN, Yuen KY.Prostaglandin E2-Mediated Impairment of Innate Immune Response to A(H1N1)pdm09 Infection in Diet-Induced Obese Mice Could Be Restored by Paracetamol. J Infect Dis. 2019 Feb 15;219(5):795-807. doi: 10.1093/infdis/jiy527. PMID: 30202973 

Zhang AJX, Zhu H, Chen Y, Li C, Li C, Chu H, Gozali L, Lee ACY, To KKW, Hung IFN, Yuen KY. Prostaglandin E2-mediated impairment of innate immune response to A(H1N1)pdm09 infection in diet-induced obese mice could be restored by paracetamol. J Infect Dis. 2018 Sep 10. doi: 10.1093/infdis/jiy527. PMID: 30202973 

Hung IF, Zhang AJ, To KK, Chan JF, Li P, Wong TL, Zhang R, Chan TC, Chan BC, Wai HH, Chan LW, Fong HP, Hui RK, Kong KL, Leung AC, Ngan AH, Tsang LW, Yeung AP, Yiu GC, Yung W, Lau JY, Chen H, Chan KH, Yuen KY. Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial. Lancet Infect Dis. 2015 Nov 6. pii: S1473-3099(15)00354-0. doi: 10.1016/S1473-3099(15)00354-0.

Yuan S, Wang R, Chan JF, Zhang AJ, Cheng T, Chik KK, Ye ZW, Wang S, Lee AC, Jin L, Li H, Jin DY, Yuen KY, Sun H. Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters. Nat Microbiol. 2020 Nov;5(11):1439-1448. doi: 10.1038/s41564-020-00802-x. Epub 2020 Oct 7. PMID: 33028965 

Lu L, Fong CH, Zhang AJ, Wu WL, Li IC, Lee AC, Dissanayake TK, Chen L, Hung IF, Chan KH, Chu H, Kok KH, Yuen KY, To KK.  Repurposing of Miltefosine as an Adjuvant for Influenza Vaccine.  Vaccines (Basel). 2020 Dec 11;8(4):754. doi: 10.3390/vaccines8040754. PMID: 33322574 Free PMC article. 

Andrew Chak-YiuLee, AJ Zhang, Jasper Fuk WooChan , CanLi, ZhimengFan, FeifeiLiu, YanxiaChen, RonghuiLiang, SiddharthSridhar, Jian PiaoCai, Vincent Kwok-ManPoon, Chris Chung-SingChan, Kelvin Kai WangTo, ShuofengYuan, JieZhou, HinChu, Kwok-YungYuen.  Oral SARS-CoV-2 Inoculation Establishes Subclinical Respiratory Infection with Virus Shedding in Golden Syrian Hamsters. Cell Reports Medicine Volume 1, Issue 7, 20 October 2020, 100121