Dr. Chan Fuk Woo, Jasper

 

陳福和醫生

 

MBBS(HK), MD(HK), PDipID(HK), MRCP(UK), FRCP(Edin), FRCPath, FHKCPath, FHKAM (Pathology)

 

Clinical Associate Professor, Department of Microbiology


Email: jfwchan@hku.hk

 

HKU Scholars Hub: http://hub.hku.hk/cris/rp/rp01736

 

ORCID : https://orcid.org/0000-0001-6336-6657

 

Google Scholar: https://scholar.google.com/citations

 

 

Research Interests

Diagnosis, treatment, and control of:

1.      Emerging viral infections with pandemic potential

2.      Emerging infectious diseases with special relevance to Asia

 

Biography

Dr. Jasper Fuk-Woo Chan is a tenured Clinical Associate Professor at the Department of Microbiology, The University of Hong Kong (HKU), Hong Kong, China. He also serves as an Honorary Consultant at Queen Mary Hospital (Hong Kong) and The University of Hong Kong-Shenzhen Hospital (Shenzhen). He received his M.B.B.S. from HKU in 2005 and underwent postgraduate specialist training at the Department of Medicine and Department of Microbiology at Queen Mary Hospital. He joined the Department of Microbiology at his alma mater as Clinical Assistant Professor in 2013. He was awarded the Sir Patrick Manson Gold Medal for the best M.D. thesis at HKU in 2017.

As a clinical microbiologist actively managing patients with infectious diseases in Hong Kong and Shenzhen, Dr. Chan is particularly passionate about conducting research on the diagnosis, treatment and control of emerging infectious diseases with pandemic potential and those with special relevance to Asia. He has authored/co-authored more than 300 (over 110 first/co-first/corresponding) journal publications in these areas (Scopus: h-index 73, citations >30,000), including (co-) first/corresponding-authored publications in The Lancet, Science, and Nature. Since 2015, Dr. Chan has been consistently ranked by Clarivate as one of the world’s top 1% scholars by citations (http://hub.hku.hk/local/top1pc/top1pc.jsp), and as a "Highly Cited Researcher" (2 fields: “Microbiology” and “Immunology”) in 2021 (https://www.hku.hk/press/news_detail_23587.html). He has served as expert member or ambassador of various international organizations, including member of the WHO ad hoc Expert Group focused on COVID-19 disease modelling (WHOCOM) and Young Ambassador of Science of the American Society for Microbiology. He has been invited to chair sessions or speak at more than 50 international and regional conferences/symposia. He is an Associate Editor for Journal of Medical Virology, American Journal of Transplantation, Pathogens, BMC Microbiology, BMC Infectious Diseases, and Zoonotic Diseases, and has been invited to review research papers for more than 50 journals (including NEJM, Lancet, and Nature series) and grant applications for international/national funding agencies in USA and Europe [European Research Council (ERC), Switzerland (SNSF), France (ANR), the Netherlands (NWO), Austria (FWF), Poland (NCN), and Croatia (HRZZ)]. He has received external competitive research grants as (co-) Principal Coordinator/Investigator from the Ministry of Science and Technology (National Key R&D Programme of China) and National Natural Science Foundation of China (NSFC) (General Program) (mainland China), and Research Grants Council (RGC) – Collaborative Research Fund (CRF) and General Research Fund (GRF) and Health and Medical Research Fund (HMRF) (Hong Kong) and own a number of patents on novel diagnostics & antivirals. He has mentored more than 30 Ph.D. and M.Phil. students at HKU.

 

Honours & Awards

2022: Fellow of the Infectious Diseases Society of America (FIDSA)

2021: Highly Cited Researcher 2021 (“Microbiology”) (Clarivate)

2021: Highly Cited Researcher 2021 (“Immunology”) (Clarivate)

2021 (since 2015): Top 1% scholar (Clarivate)

2021: HKU Outstanding Young Researcher Award (The University of Hong Kong)

2021: Biomedicines 2021 Young Investigator Award (Biomedicines)

2021: Pathogens 2021 Young Investigator Award (Pathogens)

2021: Emerging Microbes & Infections 2020 Best Paper Award (1st Place) (as first author) (Emerging Microbes & Infections)

2021: Shenzhen Science and Technological Progress Award (1st Class Award) (Science, Technology and Innovation Commission of Shenzhen Municipality, People’s Republic of China)

2021: HKU Research Output Prize (as first author for the best research output in HKU LKS Faculty of Medicine in 2020)

2021: Prize for Best Original Research by Young Fellows (Gold Medal Winner) (Hong Kong Academy of Medicine)

2020: Lo Ying Shek Chi Wai Foundation Award for Young Investigator (Lo Ying Shek Chi Wai Foundation)

2020: Kylin Science and Technology Award Capital Excellent Science and Technology Innovation Award (Beijing Society of Science and Technology Professionals Capital, Beijing, People’s Republic of China)

2019 (since 2017): ASM Young Ambassador of Science to Hong Kong (American Society for Microbiology)

2019: State Scientific and Technological Progress Award (2nd Class Award) (the National Government of the People’s Republic of China)

2019: The Most Promising Young Researcher Award (Food and Health Bureau of the HKSAR Government)

2019: The Best Poster Award (Young Investigator Category at the 32nd International Conference on Antiviral Research by International Society for Antiviral Research)

2018: The Chinese Medical Science and Technology Award (2nd Class Award) (Chinese Medical Association)

2018: Sir Patrick Manson Gold Medal (LKS Faculty of Medicine, HKU)

2016: HKU Research Output Prize (as co-author for the best research output in HKU LKS Faculty of Medicine in 2015)

2015: ASV Medical Virology Club Travel Award (American Society for Virology)

2011: Best Presentation Prize at the 7th Trainee Presentation Session (The Hong Kong College of Pathologists)

2010: Outstanding Team Award (Hospital Authority of Hong Kong)


 

Selected Publications

 Research Articles:

1.    Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, Xing F, Liu J, Yip CC, Poon RW, Tsoi HW, Lo SK, Chan KH, Poon VK, Chan WM, Ip JD, Cai JP, Cheng VC, Chen H, Hui CK, Yuen KY. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020 Feb 15;395(10223):514-523. Epub 2020 Jan 24 (IF: 202.731, Scopus citations: 5,133)

2.   Yuan S, Ye ZW, Liang R, Tang K, Zhang AJ, Lu G, Ong CP, Man Poon VK, Chan CC, Mok BW, Qin Z, Xie Y, Chu AW, Chan WM, Ip JD, Sun H, Tsang JO, Yuen TT, Chik KK, Chan CC, Cai JP, Luo C, Lu L, Yip CC, Chu H, To KK, Chen H, Jin DY, Yuen KY, Chan JF (corresponding). Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters. Science. 2022 Jul 22;377(6604):428-433. Epub 2022 Jun 23 (IF: 63.714, Scopus citations: 2)

3.   Shuai H, Chan JF (co-first), Hu B, Chai Y, Yuen TT, Yin F, Huang X, Yoon C, Hu JC, Liu H, Shi J, Liu Y, Zhu T, Zhang J, Hou Y, Wang Y, Lu L, Cai JP, Zhang AJ, Zhou J, Yuan S, Brindley MA, Zhang BZ, Huang JD, To KK, Yuen KY, Chu H. Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron. Nature. 2022 Mar;603(7902):693-699. Epub 2022 Jan 21 (IF: 69.504, Scopus citations: 88)

4.   Chu H, Hou Y, Yang D, Shuai H, Yoon C, Shi J, Chai Y, Yuen TT, Hu B, Li C, Zhao X, Wang Y, Huang X, Lee KS, Luo C, Cai JP, Poon VK, Chan CC, Zhang AJ, Yuan S, Sit KY, Foo DC, Au WK, Wong KK, Zhou J, Kok KH, Jin DY, Chan JF (co-corresponding), Yuen KY. Coronaviruses exploit a host cysteine-aspartic protease for replication. Nature. 2022 Aug 3. doi: 10.1038/s41586-022-05148-4. (IF: 69.504)

5.   Yuan S, Yin X, Meng X, Chan JF (co-first), Ye ZW, Riva L, Pache L, Chan CC, Lai PM, Chan CC, Poon VK, Lee AC, Matsunaga N, Pu Y, Yuen CK, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Lau CY, Sit KY, Au WK, Wang R, Zhang YY, Tang YD, Clausen TM, Pihl J, Oh J, Sze KH, Zhang AJ, Chu H, Kok KH, Wang D, Cai XH, Esko JD, Hung IF, Li RA, Chen H, Sun H, Jin DY, Sun R, Chanda SK, Yuen KY. Clofazimine broadly inhibits coronaviruses including SARS-CoV-2. Nature. 2021 May;593(7859):418-423. Epub 2021 Mar 16. (IF: 69.504, Scopus citations: 72)

6.   Liu L, Iketani S, Guo Y, Chan JF (co-first), Wang M, Liu L, Luo Y, Chu H, Huang Y, Nair MS, Yu J, Chik KK, Yuen TT, Yoon C, To KK, Chen H, Yin MT, Sobieszczyk ME, Huang Y, Wang HH, Sheng Z, Yuen KY, Ho DD. Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2. Nature. 2022 Feb;602(7898):676-681. Epub 2021 Dec 23. (IF: 69.504, Scopus citations: 260)

7.   Iketani S, Liu L, Guo Y, Liu L, Chan JF (co-first), Huang Y, Wang M, Luo Y, Yu J, Chu H, Chik KK, Yuen TT, Yin MT, Sobieszczyk ME, Huang Y, Yuen KY, Wang HH, Sheng Z, Ho DD. Antibody evasion properties of SARS-CoV-2 Omicron sublineages. Nature. 2022 Apr;604(7906):553-556. Epub 2022 Mar 3 (IF: 69.504, Scopus citations: 117)

8.   Xia S, Chan JF (co-first), Wang L, Jiao F, Chik KK, Chu H, Lan Q, Xu W, Wang Q, Wang C, Yuen KY, Lu L, Jiang S. Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant. Cell Res. 2022 Apr;32(4):404-406. (IF: 46.267, Scopus citations: 8)

9.    Chan JF, Chan KH, Kao RY, To KK, Zheng BJ, Li CP, Li PT, Dai J, Mok FK, Chen H, Hayden FG, Yuen KY. Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus. J Infect. 2013 Dec;67(6):606-16. (IF: 38.637, Scopus citations: 266)

10. Yuan S, Yan B, Cao J, Ye ZW, Liang R, Tang K, Luo C, Cai J, Chu H, Chung TW, To KK, Hung IF, Jin DY, Chan JF (co-corresponding), Yuen KY. SARS-CoV-2 exploits host DGAT and ADRP for efficient replication. Cell Discov. 2021 Oct 26;7(1):100. (IF: 38.079, Scopus citations: 7)

11. Chan JF, Zhang AJ, Yuan S, Poon VK, Chan CC, Lee AC, Chan WM, Fan Z, Tsoi HW, Wen L, Liang R, Cao J, Chen Y, Tang K, Luo C, Cai JP, Kok KH, Chu H, Chan KH, Sridhar S, Chen Z, Chen H, To KK, Yuen KY. Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility. Clin Infect Dis. 2020 Dec 3;71(9):2428-2446. Epub 2020 Mar 26 (IF: 20.999, Scopus citations: 550)

12. Chan JF, Yuan S, Zhang AJ, Poon VK, Chan CC, Lee AC, Fan Z, Li C, Liang R, Cao J, Tang K, Luo C, Cheng VC, Cai JP, Chu H, Chan KH, To KK, Sridhar S, Yuen KY. Surgical mask partition reduces the risk of non-contact transmission in a golden Syrian hamster model for Coronavirus Disease 2019 (COVID-19). Clin Infect Dis. 2020 Nov 19;71(16):2139-2149. Epub 2020 May 30 (IF: 20.999, Scopus citations: 151)

13. Chan JF, Poon VK, Chan CC, Chik KK, Tsang JO, Zou Z, Chan CC, Lee AC, Li C, Liang R, Cao J, Tang K, Yuen TT, Hu B, Huang X, Chai Y, Shuai H, Luo C, Cai JP, Chan KH, Sridhar S, Yin F, Kok KH, Chu H, Zhang AJ, Yuan S, Yuen KY. Low Environmental Temperature Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Golden Syrian Hamsters. Clin Infect Dis. 2021 Sep 18:ciab817. (IF: 20.999, Scopus citations: 4)

14. Chan JF, Siu GK, Yuan S, Ip JD, Cai JP, Chu AW, Chan WM, Abdullah SMU, Luo C, Chan BP, Yuen TT, Chen LL, Chik KK, Liang R, Cao H, Man Poon VK, Chan CC, Leung KH, Tam AR, Tsang OT, Chan JM, To WK, Lam BH, Lee LK, Lo HW, Wong IT, Leung JS, Wong EY, Chu H, Yip CC, Cheng VC, Chan KH, Tse H, Lung DC, Ng KH, Au AK, Hung IF, Yuen KY, To KK. Probable Animal-to-Human Transmission of SARS-CoV-2 Delta Variant AY.127 Causing a Pet Shop-Related COVID-19 Outbreak in Hong Kong. Clin Infect Dis. 2022 Mar 2:ciac171. doi: 10.1093/cid/ciac171. (IF: 20.999)

15. Chan JF, Kok KH, Zhu Z, Chu H, To KK, Yuan S, Yuen KY. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect. 2020;9:221-236. (IF: 19.568, Scopus citations: 1,634)

16. Zhang X, Chu H, Chik KK, Wen L, Shuai H, Yang D, Wang Y, Hou Y, Yuen TT, Cai JP, Yuan S, Yin F, Yuen KY, Chan JF (corresponding). hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs. Emerg Microbes Infect. 2022 Dec;11(1):519-531. (IF: 19.568, Scopus citations: 2)

17. Chu H, Hu B, Huang X, Chai Y, Zhou D, Wang Y, Shuai H, Yang D, Hou Y, Zhang X, Yuen TT, Cai JP, Zhang AJ, Zhou J, Yuan S, To KK, Chan IH, Sit KY, Foo DC, Wong IY, Ng AT, Cheung TT, Law SY, Au WK, Brindley MA, Chen Z, Kok KH, Chan JF (co-corresponding), Yuen KY. Host and viral determinants for efficient SARS-CoV-2 infection of the human lung. Nat Commun. 2021 Jan 8;12(1):134. (IF: 17.694, Scopus citations: 61)

18. Qiao W, Lau HE, Xie H, Poon VK, Chan CC, Chu H, Yuan S, Yuen TT, Chik KK, Tsang JO, Chan CC, Cai JP, Luo C, Yuen KY, Cheung KM, Chan JF (co-corresponding), Yeung KW. SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters. Nat Commun. 2022 May 9;13(1):2539. (IF: 17.694, Scopus citations: 1)

19. Chan JF, Hu B, Chai Y, Shuai H, Liu H, Shi J, Liu Y, Yoon C, Zhang J, Hu JC, Hou Y, Huang X, Yuen TT, Zhu T, Li W, Cai JP, Luo C, Yip CC, Zhang AJ, Zhou J, Yuan S, Zhang BZ, Huang JD, To KK, Yuen KY, Chu H. Virological features and pathogenicity of SARS-CoV-2 Omicron BA.2. Cell Rep Med. 2022 Aug 29:100743. (IF: 16.988)

20. Yuan S, Chu H, Huang J, Zhao X, Ye ZW, Lai PM, Wen L, Cai JP, Mo Y, Cao J, Liang R, Poon VK, Sze KH, Zhou J, To KK, Chen Z, Chen H, Jin DY, Chan JF (co-corresponding), Yuen KY. Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target. Sci Adv. 2020 Aug 28;6(35):eaba7910. (IF: 14.957, Scopus citations: 18)

21. Chu H, Shuai H, Hou Y, Zhang X, Wen L, Huang X, Hu B, Yang D, Wang Y, Yoon C, Wong BH, Li C, Zhao X, Poon VK, Cai JP, Wong KK, Yeung ML, Zhou J, Au-Yeung RK, Yuan S, Jin DY, Kok KH, Perlman S, Chan JF (co-corresponding), Yuen KY. Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity. Sci Adv. 2021 Jun 16;7(25):eabf8577. (IF: 14.957, Scopus citations: 23)

22. Chan JF, Yip CC, To KK, Tang TH, Wong SC, Leung KH, Fung AY, Ng AC, Zou Z, Tsoi HW, Choi GK, Tam AR, Cheng VC, Chan KH, Tsang OT, Yuen KY. Improved Molecular Diagnosis of COVID-19 by the Novel, Highly Sensitive and Specific COVID-19-RdRp/Hel Real-Time Reverse Transcription-PCR Assay Validated In Vitro and with Clinical Specimens. J Clin Microbiol. 2020 Apr 23;58(5):e00310-20. (IF: 11.677, Scopus citations: 584)

23. Yan B, Yuan S, Cao J, Fung K, Lai PM, Yin F, Sze KH, Qin Z, Xie Y, Ye ZW, Yuen TT, Chik KK, Tsang JO, Zou Z, Chan CC, Luo C, Cai JP, Chan KH, Chung TW, Tam AR, Chu H, Jin DY, Hung IF, Yuen KY, Kao RY, Chan JF (corresponding). Phosphatidic acid phosphatase 1 impairs SARS-CoV-2 replication by affecting the glycerophospholipid metabolism pathway. Int J Biol Sci. 2022 Jul 11;18(12):4744-4755. (IF: 10.750)

24. Chan JF, Yao Y, Yeung ML, Deng W, Bao L, Jia L, Li F, Xiao C, Gao H, Yu P, Cai JP, Chu H, Zhou J, Chen H, Qin C, Yuen KY. Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset. J Infect Dis. 2015;212:1904-13. (IF: 7.759, Scopus citations: 479)

25. Chan JF, Chan KH, Choi GK, To KK, Tse H, Cai JP, Yeung ML, Cheng VC, Chen H, Che XY, Lau SK, Woo PC, Yuen KY. Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications for disease pathogenesis and clinical manifestation. J Infect Dis. 2013;207:1743-52. (IF: 7.759, Scopus citations: 167)

Reviews:

1.   Chan JF, Lau SK, To KK, Cheng VC, Woo PC, Yuen KY. Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease. Clin Microbiol Rev. 2015 Apr;28(2):465-522. (IF: 50.129, Scopus citations: 567)

2.   Chan JF, To KK, Tse H, Jin DY, Yuen KY. Interspecies transmission and emergence of novel viruses: lessons from bats and birds. Trends Microbiol. 2013 Oct;21(10):544-55. (IF: 18.230, Scopus citations: 328)

3.   Zumla A, Chan JF (co-first), Azhar EI, Hui DS, Yuen KY. Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. (IF: 112.288, Scopus citations: 1,042)

 

Joining our team:

The Chan laboratory is recruiting MPhil & PhD students, research assistants, and Post-Doc Fellows. Interested candidates please send a cover letter detailing your research interests and CV to Dr. Jasper FW Chan (jfwchan@hku.hk).