Dr. Chan Fuk Woo, Jasper

 

陳福和醫生

 

MBBS(HK), MD(HK), PDipID(HK), MRCP(UK), FRCP(Edin), FRCPath, FHKCPath, FHKAM (Pathology)

 

Clinical Assistant Professor, Department of Microbiology


Email: jfwchan@hku.hk

 

HKU Scholars Hub: http://hub.hku.hk/cris/rp/rp01736

 

ORCID : https://orcid.org/0000-0001-6336-6657

 

Google Scholar: https://scholar.google.com/citations

 

 

Research Interests

Diagnosis, treatment, and control of:

1. Emerging viral infections with pandemic potential
2. Emerging infectious diseases with special relevance to Hong Kong and China

 

Biography

Dr. Jasper Fuk-Woo Chan is a Clinical Assistant Professor at the Department of Microbiology, The University of Hong Kong (HKU), Hong Kong, China. He received his M.B.B.S. from HKU in 2005 and underwent postgraduate specialist training at the Department of Medicine and Department of Microbiology at Queen Mary Hospital, Hong Kong, to become Fellow of the Royal College of Physicians of Edinburgh, the Royal College of Pathologists of the United Kingdom, the Hong Kong College of Pathologists, and the Hong Kong Academy of Medicine. He joined the Department of Microbiology at his alma mater as Honorary Assistant Professor in 2008 and Clinical Assistant Professor in 2013. He was awarded the Sir Patrick Manson Gold Medal for the best M.D. thesis at HKU in 2017.

As a clinical microbiologist actively managing patients with infectious diseases in Hong Kong and Shenzhen, Dr. Chan is particularly passionate about conducting research on the diagnosis, treatment and control of emerging infectious diseases with pandemic potential and those with special relevance to Hong Kong and China. He has authored/co-authored more than 240 (over 70 first/ co-first/corresponding) journal publications in these areas (Scopus: h-index 59, citations >17,000), including first/co-first/corresponding-authored publications in The Lancet, Nature, Nature Microbiology, Nature Communications, Cell Host & Microbe, Science Advances, and Clinical Infectious Diseases. Since 2015, Dr. Chan has been consistently ranked by Clarivate Analytics’ Essential Science Indicators as one of the world’s top 1% scholars. He has served as expert member or ambassador of various international organizations, including member of the WHO ad hoc Expert Group focused on COVID-19 disease modelling (WHOCOM) and Young Ambassador of Science of the American Society for Microbiology. He has been invited to chair sessions or speak at more than 30 international and regional conferences/symposia, including ASM’s 54th ICAAC, 19th Congress of Asian Pacific Society of Respirology, 17th Asia-Pacific Congress of Clinical Microbiology and Infection, and 9th Asian Congress of Pediatric Infectious Diseases. He is an Associate Editor for BMC Infectious Diseases and BMC Microbiology, and has been been invited to review research papers for more than 50 journals (including The Lancet, Lancet Infectious Diseases, Lancet Respiratory Medicine, Nature Communications, and Nature Protocols) and grant applications for international/national funding agencies in USA, Switzerland (SNSF), France (ANR), the Netherlands (NWO), Austria (FWF), and Poland (NCN). He has received >24 million HKD of external peer-reviewed research funding as Principal/Co-Principal Investigator and own a number of patents on novel diagnostics & antivirals.

 

Honours & Awards

2021: Emerging Microbes & Infections 2020 Best Paper Award (1st Place) (as first author)
2020 (since 2015): Top 1% scholar (Clarivate Analytics’ Essential Science Indicators)
2020: Lo Ying Shek Chi Wai Foundation Award for Young Investigator (Lo Ying Shek Chi Wai Foundation)
2020: Kylin Science and Technology Award Capital Excellent Science and Technology Innovation Award (Beijing Society of Science and Technology Professionals Capital, Beijing, People’s Republic of China)
2019 (since 2017): ASM Young Ambassador of Science to Hong Kong (American Society for Microbiology)
2019: State Scientific and Technological Progress Award (2nd Class Award) (the National Government of the People’s Republic of China)
2019: The Most Promising Young Researcher Award (Food and Health Bureau of the HKSAR Government)
2019: The Best Poster Award (Young Investigator Category at the 32nd International Conference on Antiviral Research by International Society for Antiviral Research)
2018: The Chinese Medical Science and Technology Award (2nd Class Award) (Chinese Medical Association)
2018: Sir Patrick Manson Gold Medal (LKS Faculty of Medicine, HKU)
2016: Faculty Research Output Prize (as co-investigator) (LKS Faculty of Medicine, HKU)
2015: ASV Medical Virology Club Travel Award (American Society for Virology)
2011: Best Presentation Prize (The Hong Kong College of Pathologists)
2010: Outstanding Team Award (Hospital Authority of Hong Kong)

 

Selected Publications

1. Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, Xing F, Liu J, Yip CC, Poon RW, Tsoi HW, Lo SK, Chan KH, Poon VK, Chan WM, Ip JD, Cai JP, Cheng VC, Chen H, Hui CK, Yuen KY. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395:514-523. (IF: 60.392, Scopus citations: 3,002)

2. Yuan S, Yin X, Meng X, Chan JF (co-first), Ye ZW, Riva L, Pache L, Chan CC, Lai PM, Chan CC, Poon VK, Lee AC, Matsunaga N, Pu Y, Yuen CK, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Lau CY, Sit KY, Au WK, Wang R, Zhang YY, Tang YD, Clausen TM, Pihl J, Oh J, Sze KH, Zhang AJ, Chu H, Kok KH, Wang D, Cai XH, Esko JD, Hung IF, Li RA, Chen H, Sun H, Jin DY, Sun R, Chanda SK, Yuen KY. Clofazimine broadly inhibits coronaviruses including SARS-CoV-2. Nature. 2021 Mar 16. doi: 10.1038/s41586-021-03431-4. (IF: 42.778)

3. Chan JF, Zhang AJ, Yuan S, Poon VK, Chan CC, Lee AC, Chan WM, Fan Z, Tsoi HW, Wen L, Liang R, Cao J, Chen Y, Tang K, Luo C, Cai JP, Kok KH, Chu H, Chan KH, Sridhar S, Chen Z, Chen H, To KK, Yuen KY. Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility. Clin Infect Dis. 2020 Dec 3;71(9):2428-2446. (IF: 8.313, Scopus citations: 217)

4. Chan JF, Yuan S, Zhang AJ, Poon VK, Chan CC, Lee AC, Fan Z, Li C, Liang R, Cao J, Tang K, Luo C, Cheng VC, Cai JP, Chu H, Chan KH, To KK, Sridhar S, Yuen KY. Surgical mask partition reduces the risk of non-contact transmission in a golden Syrian hamster model for Coronavirus Disease 2019 (COVID-19). Clin Infect Dis. 2020 Nov 19;71(16):2139-2149. (IF: 8.313, Scopus citations: 43)

5. Chan JF, Kok KH, Zhu Z, Chu H, To KK, Yuan S, Yuen KY. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect. 2020;9:221-236. (IF: 5.776, Scopus citations: 865)

6. Chan JF, Yip CC, To KK, Tang TH, Wong SC, Leung KH, Fung AY, Ng AC, Zou Z, Tsoi HW, Choi GK, Tam AR, Cheng VC, Chan KH, Tsang OT, Yuen KY. Improved molecular diagnosis of COVID-19 by the novel, highly sensitive and specific COVID-19-RdRp/Hel real-time reverse transcription-polymerase chain reaction assay validated in vitro and with clinical specimens. J Clin Microbiol. 2020;58. (IF: 5.897, Scopus citations: 306)

7. Zhou D, Chan JF (co-first), Zhou B, Zhou R, Li S, Shan S, Liu L, Zhang AJ, Chen SJ, Chan CC, Xu H, Poon VK, Yuan S, Li C, Chik KK, Chan CC, Cao J, Chan CY, Kwan KY, Du Z, Lau TT, Zhang Q, Zhou J, To KK, Zhang L, Ho DD, Yuen KY, Chen Z. Robust SARS-CoV-2 Infection in Nasal Turbinates after Treatment with Systemic Neutralizing Antibodies. Cell Host Microbe. 2021. (Epub ahead of print) (IF: 15.923)

8. Chu H, Chan JF (co-first), Wang Y, Yuen TT, Chai Y, Hou Y, Shuai H, Yang D, Hu B, Huang X, Zhang X, Cai JP, Zhou J, Yuan S, Kok KH, To KK, Chan IH, Zhang AJ, Sit KY, Au WK, Yuen KY. Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19. Clin Infect Dis. 2020 Sep 12;71(6):1400-1409. (IF: 8.313, Scopus citations: 203)

9. Chu H, Chan JF (co-first), Yuen TT, Shuai H, Yuan S, Wang Y, Hu B, Yip CC, Tsang JO, Huang X, Chai Y, Yang D, Hou Y, Chik KK, Zhang X, Fung AY, Tsoi HW, Cai JP, Chan WM, Ip JD, Chu AW, Zhou J, Lung DC, Kok KH, To KK, Tsang OT, Chan KH, Yuen KY. Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study. Lancet Microbe. 2020 May;1(1):e14-e23.

10. Yuan S, Chu H, Huang J, Zhao X, Ye ZW, Lai PM, Wen L, Cai JP, Mo Y, Cao J, Liang R, Poon VK, Sze KH, Zhou J, To KK, Chen Z, Chen H, Jin DY, Chan JF (co-corresponding), Yuen KY. Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target. Sci Adv. 2020 Aug 28;6(35):eaba7910. (IF: 13.116, Scopus citations: 2)

11. Chu H, Hu B, Huang X, Chai Y, Zhou D, Wang Y, Shuai H, Yang D, Hou Y, Zhang X, Yuen TT, Cai JP, Zhang AJ, Zhou J, Yuan S, To KK, Chan IH, Sit KY, Foo DC, Wong IY, Ng AT, Cheung TT, Law SY, Au WK, Brindley MA, Chen Z, Kok KH, Chan JF (co-corresponding), Yuen KY. Host and viral determinants for efficient SARS-CoV-2 infection of the human lung. Nat Commun. 2021 Jan 8;12(1):134. (IF: 12.121)

12. Li C, Chen YX, Liu FF, Lee AC, Zhao Y, Ye ZH, Cai JP, Chu H, Zhang RQ, Chan KH, Chiu KH, Lung DC, Sridhar S, Hung IF, To KK, Zhang AJ, Chan JF (co-corresponding), Yuen KY. Absence of vaccine-enhanced disease with unexpected positive protection against SARS-CoV-2 by inactivated vaccine given within three days of virus challenge in Syrian hamster model. Clin Infect Dis. 2021 Jan 30:ciab083. doi: 10.1093/cid/ciab083. (IF: 8.313)

13. Yuan S, Wang R, Chan JF (co-first), Zhang AJ, Cheng T, Chik KK, Ye ZW, Wang S, Lee AC, Jin L, Li H, Jin DY, Yuen KY, Sun H. Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters. Nat Microbiol. 2020 Nov;5(11):1439-1448. (IF: 15.540, Scopus citations: 6)

14. Yuan S, Chu H, Chan JF (co-first), Ye ZW, Wen L, Yan B, Lai PM, Tee KM, Huang J, Chen D, Li C, Zhao X, Yang D, Chiu MC, Yip C, Poon VK, Chan CC, Sze KH, Zhou J, Chan IH, Kok KH, To KK, Kao RY, Lau JY, Jin DY, Perlman S, Yuen KY. SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target. Nat Commun. 2019;10:120. (IF: 12.121, Scopus citations: 59)

15. Zhang AJ, Lee AC, Chan JF (co-first), Liu F, Li C, Chen Y, Chu H, Lau SY, Wang P, Chan CC, Poon VK, Yuan S, To KK, Chen H, Yuen KY. Co-infection by severe acute respiratory syndrome coronavirus 2 and influenza A(H1N1)pdm09 virus enhances the severity of pneumonia in golden Syrian hamsters. Clin Infect Dis. 2020 Nov 20:ciaa1747. doi: 10.1093/cid/ciaa1747. (IF: 8.313)

16. Zhang AJ, Lee AC, Chu H, Chan JF (co-first), Fan Z, Li C, Liu F, Chen Y, Yuan S, Poon VK, Chan CC, Cai JP, Wu KL, Sridhar S, Chan YS, Yuen KY. SARS-CoV-2 infects and damages the mature and immature olfactory sensory neurons of hamsters. Clin Infect Dis. 2020 Jul 15:ciaa995. doi: 10.1093/cid/ciaa995. (IF: 8.313)

17. Chan JF, Yip CC, Tsang JO, Tee KM, Cai JP, Chik KK, Zhu Z, Chan CC, Choi GK, Sridhar S, Zhang AJ, Lu G, Chiu K, Lo AC, Tsao SW, Kok KH, Jin DY, Chan KH, Yuen KY. Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs. Emerg Microbes Infect. 2016;5:e93. (IF: 5.776, Scopus citations: 99)

18. Chan JF, Choi GK, Tsang AK, Tee KM, Lam HY, Yip CC, To KK, Cheng VC, Yeung ML, Lau SK, Woo PC, Chan KH, Tang BS, Yuen KY. Development and Evaluation of Novel Real-Time Reverse Transcription-PCR Assays with Locked Nucleic Acid Probes Targeting Leader Sequences of Human-Pathogenic Coronaviruses. J Clin Microbiol. 2015;53:2722-6. (IF: 5.897, Scopus citations: 38)

19. Chan JF, Zhang AJ, Chan CC, Yip CC, Mak WW, Zhu H, Poon VK, Tee KM, Zhu Z, Cai JP, Tsang JO, Chik KK, Yin F, Chan KH, Kok KH, Jin DY, Au-Yeung RK, Yuen KY. Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons. EBioMedicine. 2016;14:112-122. (IF: 5.736, Scopus citations: 60)

20. Chan JF, Yao Y, Yeung ML, Deng W, Bao L, Jia L, Li F, Xiao C, Gao H, Yu P, Cai JP, Chu H, Zhou J, Chen H, Qin C, Yuen KY. Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset. J Infect Dis. 2015;212:1904-13. (IF: 5.022, Scopus citations: 337)

21. Chan JF, Chan KH, Choi GK, To KK, Tse H, Cai JP, Yeung ML, Cheng VC, Chen H, Che XY, Lau SK, Woo PC, Yuen KY. Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications for disease pathogenesis and clinical manifestation. J Infect Dis. 2013;207:1743-52. (IF: 5.022, Scopus citations: 135)

 

Reviews / Personal Views:

1. Chan JF, Lau SK, To KK, Cheng VC, Woo PC, Yuen KY. Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease. Clin Microbiol Rev. 2015;28:465-522. (IF: 22.556, Scopus citations: 391)

2. Chan JF, To KK, Tse H, Jin DY, Yuen KY. Interspecies transmission and emergence of novel viruses: lessons from bats and birds. Trends Microbiol. 2013;21:544-55. (IF: 13.546, Scopus citations: 201)

3. Zumla A, Chan JF (co-first), Azhar EI, Hui DS, Yuen KY. Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016;15:327-47. (IF: 64.797, Scopus citations: 604)

4. To KK, Chan JF (co-first), Chen H, Li L, Yuen KY. The emergence of influenza A H7N9 in human beings 16 years after influenza A H5N1: a tale of two cities. Lancet Infect Dis. 2013;13:809-21. (IF: 24.446, Scopus citations: 106)

Joining our team:

We welcome motivated individuals to join us as research assistants, MPhil & PhD students, and Post-Doc Fellows. Interested candidates please send a cover letter detailing your research interests and CV to Dr. Jasper FW Chan (jfwchan@hku.hk).