Dr. Chan Fuk Woo, Jasper




MBBS(HK), MD(HK), PDipID(HK), MRCP(UK), FRCP(Edin), FRCPath, FHKCPath, FHKAM (Pathology)


Clinical Associate Professor, Department of Microbiology

Email: jfwchan@hku.hk


HKU Scholars Hub: http://hub.hku.hk/cris/rp/rp01736


ORCID : https://orcid.org/0000-0001-6336-6657


Google Scholar: https://scholar.google.com/citations



Research Interests

Diagnosis, treatment, and control of:

1.      Emerging viral infections with pandemic potential

2.      Emerging infectious diseases with special relevance to Hong Kong and China



Dr. Jasper Fuk-Woo Chan is a tenured Clinical Associate Professor at the Department of Microbiology, The University of Hong Kong (HKU), Hong Kong, China. He also serves as an Honorary Consultant at Queen Mary Hospital (Hong Kong) and The University of Hong Kong-Shenzhen Hospital (Shenzhen). He received his M.B.B.S. from HKU in 2005 and underwent postgraduate specialist training at the Department of Medicine and Department of Microbiology at Queen Mary Hospital. He was awarded the Sir Patrick Manson Gold Medal for the best M.D. thesis at HKU in 2017. He joined the Department of Microbiology at his alma mater as Clinical Assistant Professor in 2013 and was promoted to Clinical Associate Professor in 2021.

As a clinical microbiologist actively managing patients with infectious diseases in Hong Kong and Shenzhen, Dr. Chan is particularly passionate about conducting research on the diagnosis, treatment and control of emerging infectious diseases with pandemic potential and those with special relevance to Hong Kong and China. He has authored/co-authored more than 280 (over 80 first/co-first/corresponding) journal publications in these areas (Scopus: h-index 69, citations >25,500), including first/co-first/corresponding-authored publications in The Lancet, Nature, Nature Microbiology, Nature Communications, Cell Host & Microbe, Science Advances, and Clinical Infectious Diseases. Since 2015, Dr. Chan has been consistently ranked by Clarivate as one of the world’s top 1% scholars by citations (http://hub.hku.hk/local/top1pc/top1pc.jsp), and as a "Highly Cited Researcher" (2 fields: “Microbiology” and “Immunology”) in 2021 (https://www.hku.hk/press/news_detail_23587.html). He has served as expert member or ambassador of various international organizations, including member of the WHO ad hoc Expert Group focused on COVID-19 disease modelling (WHOCOM) and Young Ambassador of Science of the American Society for Microbiology. He has been invited to chair sessions or speak at more than 30 international and regional conferences/symposia. He is an Associate Editor for American Journal of Transplantation, Pathogens, BMC Infectious Diseases, BMC Microbiology, Zoonotic Diseases, and Frontiers in Virology, and has been invited to review research papers for more than 50 journals (including The Lancet and Nature series) and grant applications for international/national funding agencies in USA, Switzerland (SNSF), France (ANR), the Netherlands (NWO), Austria (FWF), Poland (NCN), and Croatia (HRZZ). He has received >30 million HKD of external peer-reviewed research funding as Principal/Co-Principal Investigator (including funding from the Research Grants Council – Collaborative Research Fund and General Research Fund, Health and Medical Research Fund, and the Ministry of Science and Technology of the People’s Republic of China) and own a number of patents on novel diagnostics & antivirals.


Honours & Awards

2021: Highly Cited Researcher 2021 (in two fields: “Microbiology” & “Immunology”) (Clarivate)

2021 (since 2015): Top 1% scholar (Clarivate)

2021: HKU Outstanding Young Researcher Award (HKU)

2021: Biomedicines 2021 Young Investigator Award (Biomedicines)

2021: Pathogens 2021 Young Investigator Award (Pathogens)

2021:   Emerging Microbes & Infections 2020 Best Paper Award (1st Place) (as first author) (Emerging Microbes & Infections)

2021:   Shenzhen Science and Technological Progress Award (1st Class Award) (Science, Technology and Innovation Commission of Shenzhen Municipality, China)

2021:   Research Output Prize (as first author for the best research output in HKU LKS Faculty of Medicine in 2020)

2021: Prize for Best Original Research by Young Fellows (Gold Medal Winner) (Hong Kong Academy of Medicine)

2020: Lo Ying Shek Chi Wai Foundation Award for Young Investigator (Lo Ying Shek Chi Wai Foundation)

2020: Kylin Science and Technology Award Capital Excellent Science and Technology Innovation Award (Beijing Society of Science and Technology Professionals Capital, Beijing, People’s Republic of China)

2019 (since 2017): ASM Young Ambassador of Science to Hong Kong (American Society for Microbiology)

2019: State Scientific and Technological Progress Award (2nd Class Award) (the National Government of the People’s Republic of China)

2019: The Most Promising Young Researcher Award (Food and Health Bureau of the HKSAR Government)

2019: The Best Poster Award (Young Investigator Category at the 32nd International Conference on Antiviral Research by International Society for Antiviral Research)

2018: The Chinese Medical Science and Technology Award (2nd Class Award) (Chinese Medical Association)

2018: Sir Patrick Manson Gold Medal (LKS Faculty of Medicine, HKU)

2016: Faculty Research Output Prize (as co-author for the best research output in HKU LKS Faculty of Medicine in 2015)

2015: ASV Medical Virology Club Travel Award (American Society for Virology)

2011: Best Presentation Prize (The Hong Kong College of Pathologists)

2010: Outstanding Team Award (Hospital Authority of Hong Kong)



Selected Publications


Research Articles:

1.   Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, Xing F, Liu J, Yip CC, Poon RW, Tsoi HW, Lo SK, Chan KH, Poon VK, Chan WM, Ip JD, Cai JP, Cheng VC, Chen H, Hui CK, Yuen KY. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395:514-523. (IF: 79.321, Scopus citations: 4,557)

2.   Shuai H, Chan JF (co-first), Hu B, Chai Y, Yuen TT, Yin F, Huang X, Yoon C, Hu JC, Liu H, Shi J, Liu Y, Zhu T, Zhang J, Hou Y, Wang Y, Lu L, Cai JP, Zhang AJ, Zhou J, Yuan S, Brindley MA, Zhang BZ, Huang JD, To KK, Yuen KY, Chu H. Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron. Nature. 2022 Jan 21. doi: 10.1038/s41586-022-04442-5. Online ahead of print. (IF: 49.962)

3.   Yuan S, Yin X, Meng X, Chan JF (co-first), Ye ZW, Riva L, Pache L, Chan CC, Lai PM, Chan CC, Poon VK, Lee AC, Matsunaga N, Pu Y, Yuen CK, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Lau CY, Sit KY, Au WK, Wang R, Zhang YY, Tang YD, Clausen TM, Pihl J, Oh J, Sze KH, Zhang AJ, Chu H, Kok KH, Wang D, Cai XH, Esko JD, Hung IF, Li RA, Chen H, Sun H, Jin DY, Sun R, Chanda SK, Yuen KY. Clofazimine broadly inhibits coronaviruses including SARS-CoV-2. Nature. 2021 May;593(7859):418-423. (IF: 49.962, Scopus citations: 31)

4.   Liu L, Iketani S, Guo Y, Chan JF (co-first), Wang M, Liu L, Luo Y, Chu H, Huang Y, Nair MS, Yu J, Chik KK, Yuen TT, Yoon C, To KK, Chen H, Yin MT, Sobieszczyk ME, Huang Y, Wang HH, Sheng Z, Yuen KY, Ho DD. Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2. Nature. 2021 Dec 23. doi: 10.1038/s41586-021-04388-0. (IF: 49.962) 

5.   Chan JF, Zhang AJ, Yuan S, Poon VK, Chan CC, Lee AC, Chan WM, Fan Z, Tsoi HW, Wen L, Liang R, Cao J, Chen Y, Tang K, Luo C, Cai JP, Kok KH, Chu H, Chan KH, Sridhar S, Chen Z, Chen H, To KK, Yuen KY. Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility. Clin Infect Dis. 2020 Dec 3;71(9):2428-2446. (IF: 9.079, Scopus citations: 434)

6.   Chan JF, Yuan S, Zhang AJ, Poon VK, Chan CC, Lee AC, Fan Z, Li C, Liang R, Cao J, Tang K, Luo C, Cheng VC, Cai JP, Chu H, Chan KH, To KK, Sridhar S, Yuen KY. Surgical mask partition reduces the risk of non-contact transmission in a golden Syrian hamster model for Coronavirus Disease 2019 (COVID-19). Clin Infect Dis. 2020 Nov 19;71(16):2139-2149. (IF: 9.079, Scopus citations: 113)

7.   Chan JF, Poon VK, Chan CC, Chik KK, Tsang JO, Zou Z, Chan CC, Lee AC, Li C, Liang R, Cao J, Tang K, Yuen TT, Hu B, Huang X, Chai Y, Shuai H, Luo C, Cai JP, Chan KH, Sridhar S, Yin F, Kok KH, Chu H, Zhang AJ, Yuan S, Yuen KY. Low Environmental Temperature Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Golden Syrian Hamsters. Clin Infect Dis. 2021 Sep 18:ciab817. (IF: 9.079)

8.   Chan JF, Kok KH, Zhu Z, Chu H, To KK, Yuan S, Yuen KY. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect. 2020;9:221-236. (IF: 7.163, Scopus citations: 1,398)

9.   Chan JF, Yip CC, To KK, Tang TH, Wong SC, Leung KH, Fung AY, Ng AC, Zou Z, Tsoi HW, Choi GK, Tam AR, Cheng VC, Chan KH, Tsang OT, Yuen KY. Improved molecular diagnosis of COVID-19 by the novel, highly sensitive and specific COVID-19-RdRp/Hel real-time reverse transcription-polymerase chain reaction assay validated in vitro and with clinical specimens. J Clin Microbiol. 2020;58. (IF: 5.948, Scopus citations: 496)

10. Zhou D, Chan JF (co-first), Zhou B, Zhou R, Li S, Shan S, Liu L, Zhang AJ, Chen SJ, Chan CC, Xu H, Poon VK, Yuan S, Li C, Chik KK, Chan CC, Cao J, Chan CY, Kwan KY, Du Z, Lau TT, Zhang Q, Zhou J, To KK, Zhang L, Ho DD, Yuen KY, Chen Z. Robust SARS-CoV-2 Infection in Nasal Turbinates after Treatment with Systemic Neutralizing Antibodies. Cell Host Microbe. 2021. (Epub ahead of print) (IF: 21.023, Scopus citations: 23)

11. Chu H, Chan JF (co-first), Wang Y, Yuen TT, Chai Y, Hou Y, Shuai H, Yang D, Hu B, Huang X, Zhang X, Cai JP, Zhou J, Yuan S, Kok KH, To KK, Chan IH, Zhang AJ, Sit KY, Au WK, Yuen KY. Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19. Clin Infect Dis. 2020 Sep 12;71(6):1400-1409. (IF: 9.079, Scopus citations: 353)

12. Chu H, Chan JF (co-first), Yuen TT, Shuai H, Yuan S, Wang Y, Hu B, Yip CC, Tsang JO, Huang X, Chai Y, Yang D, Hou Y, Chik KK, Zhang X, Fung AY, Tsoi HW, Cai JP, Chan WM, Ip JD, Chu AW, Zhou J, Lung DC, Kok KH, To KK, Tsang OT, Chan KH, Yuen KY. Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study. Lancet Microbe. 2020 May;1(1):e14-e23.

13. Chu H, Hu B, Huang X, Chai Y, Zhou D, Wang Y, Shuai H, Yang D, Hou Y, Zhang X, Yuen TT, Cai JP, Zhang AJ, Zhou J, Yuan S, To KK, Chan IH, Sit KY, Foo DC, Wong IY, Ng AT, Cheung TT, Law SY, Au WK, Brindley MA, Chen Z, Kok KH, Chan JF (co-corresponding), Yuen KY. Host and viral determinants for efficient SARS-CoV-2 infection of the human lung. Nat Commun. 2021 Jan 8;12(1):134. (IF: 14.919, Scopus citations: 38)

14. Yuan S, Chu H, Huang J, Zhao X, Ye ZW, Lai PM, Wen L, Cai JP, Mo Y, Cao J, Liang R, Poon VK, Sze KH, Zhou J, To KK, Chen Z, Chen H, Jin DY, Chan JF (co-corresponding), Yuen KY. Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target. Sci Adv. 2020 Aug 28;6(35):eaba7910. (IF: 14.136, Scopus citations: 11)

15. Chan JF, Yao Y, Yeung ML, Deng W, Bao L, Jia L, Li F, Xiao C, Gao H, Yu P, Cai JP, Chu H, Zhou J, Chen H, Qin C, Yuen KY. Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset. J Infect Dis. 2015;212:1904-13. (IF: 5.226, Scopus citations: 444)

16. Chan JF, Zhang AJ, Chan CC, Yip CC, Mak WW, Zhu H, Poon VK, Tee KM, Zhu Z, Cai JP, Tsang JO, Chik KK, Yin F, Chan KH, Kok KH, Jin DY, Au-Yeung RK, Yuen KY. Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons. EBioMedicine. 2016;14:112-122. (IF: 8.143, Scopus citations: 66)

17. Chan JF, Yip CC, Tsang JO, Tee KM, Cai JP, Chik KK, Zhu Z, Chan CC, Choi GK, Sridhar S, Zhang AJ, Lu G, Chiu K, Lo AC, Tsao SW, Kok KH, Jin DY, Chan KH, Yuen KY. Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs. Emerg Microbes Infect. 2016;5:e93. (IF: 7.163, Scopus citations: 117)

18. Chan JF, Chan KH, Choi GK, To KK, Tse H, Cai JP, Yeung ML, Cheng VC, Chen H, Che XY, Lau SK, Woo PC, Yuen KY. Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications for disease pathogenesis and clinical manifestation. J Infect Dis. 2013;207:1743-52. (IF: 5.226, Scopus citations: 159)

19. Yuan S, Yan B, Cao J, Ye ZW, Liang R, Tang K, Luo C, Cai J, Chu H, Chung TW, To KK, Hung IF, Jin DY, Chan JF (co-corresponding), Yuen KY. SARS-CoV-2 exploits host DGAT and ADRP for efficient replication. Cell Discov. 2021;7:100. (IF: 10.849)

20. Yuan S, Wang R, Chan JF (co-first), Zhang AJ, Cheng T, Chik KK, Ye ZW, Wang S, Lee AC, Jin L, Li H, Jin DY, Yuen KY, Sun H. Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters. Nat Microbiol. 2020 Nov;5(11):1439-1448. (IF: 17.145, Scopus citations: 57)



1.   Chan JF, Lau SK, To KK, Cheng VC, Woo PC, Yuen KY. Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease. Clin Microbiol Rev. 2015;28:465-522. (IF: 26.132, Scopus citations: 522)

2.   Chan JF, To KK, Tse H, Jin DY, Yuen KY. Interspecies transmission and emergence of novel viruses: lessons from bats and birds. Trends Microbiol. 2013;21:544-55. (IF: 17.079, Scopus citations: 293)

3.   Zumla A, Chan JF (co-first), Azhar EI, Hui DS, Yuen KY. Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016;15:327-47. (IF: 84.694, Scopus citations: 922)


Joining our team:

We welcome motivated individuals to join us as research assistants, MPhil & PhD students, and Post-Doc Fellows. Interested candidates please send a cover letter detailing your research interests and CV to Dr. Jasper FW Chan (jfwchan@hku.hk).