Dr. CHAN Kwok Hung


PhD (HK), FRCPath (UK), FIBMS (UK), CBiol, FSB(UK)


Honorary Assistant Professor, Department of Microbiology


Email: chankh2@hku.hk


ORCID : https://orcid.org/0000-0003-1771-8249



Research Interests:

» Rapid diagnosis and prevention of respiratory virus infections
» Emerging infectious diseases
» EBV associated diseases



Selected publications:

1. Wang P, Lau SY, Deng S, Chen P, Mok BWY, Zhang AJ, Andrew Chak-Yiu Lee ACY, Chan KH, Tam RCY, Xu H, Zhou R, Song W, Liu L, To KKW, Chan JFW, Chen Z, Yuen KY, Chen H. Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein. Nat Commun. 2021; 12: 2790.

2. Yeung ML, Teng JLL, Jia L, Zhang C, Huang C, Cai JP, Zhou R, Chan KH, Zhao H, Zhu L, Siu KL, Fung SY, Yung S, Chan TM, To KKW, Chan JFW, Cai Z, Lau SKP, Chen Z, Jin DY, Woo PCY, Yuen KY. Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system. Cell. 2021 Apr 15; 184(8): 2212–2228.e12.

3. Chan KH, Sridhar S, Zhang RR, Chu H, Fung AYF, Chan g, J.F-W. Chan JFW, To KKW, Hung IFN, Cheng VCC, Yuen KY. Factors affecting stability and infectivity of SARS-CoV-2. J Hosp Infect. 2020 Oct; 106(2): 226–231.

4. Lam JKP, Azzi T, Hui KF, Wong AMG, McHugh D, Caduff N, Chan KH, Münz C, Chiang AKS. Co-infection of Cytomegalovirus and Epstein-Barr Virus Diminishes the Frequency of CD56dimNKG2A+KIR− NK Cells and Contributes to Suboptimal Control of EBV in Immunosuppressed Children With Post-transplant Lymphoproliferative Disorder. Front Immunol. 2020; 11: 1231

5. Hung IFN, Lung KC, Tso EYK, Liu R, Chung TWH, Chu MY, Ng YY, Lo J, Chan J, Tam AR, Shum HP, Chan V, Wu AKL, Sin KM, Leung WS, Law WL, Lung DC, Sin S, Yeung P, Yip CCY, Zhang RR, Fung AYF, Yan EYW, Leung KH, Ip JD, Chu AWH, Chan WM, Ng ACK, Lee R, Fung K, Yeung A, Wu TC, Chan JWM, Yan WW, Chan WM, Chan JFW, Lie AKW, Tsang OTY, Cheng VCC, Que TL, Lau CS, Chan KH, To KKW, Yuen KY. Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial. Lancet. 2020 30 May-5 June; 395(10238): 1695–1704.

6. Leung NHL, Chu DKW, Shiu EYC, Chan KH, McDevitt JJ, Hau BJP, Yen HL, Li Y, Ip DKM, Peiris JSM, Seto WH, Leung GM, Milton DK, Cowling BJ. Author Correction: Respiratory virus shedding in exhaled breath and efficacy of face masks. Nat Med. 2020 May 27: 1. doi: 10.1038/s41591-020-0946-9. Corrects: Nat Med. 2020 Apr 3.

7. Chan JFW, Yuan S, Kok KH, To KKW, Chu H, Yang J, Xing F, Liu J, Yip CCY, Poon RWS, Tsoi HW, Simon Lo SKF, Chan KH, Poon VKM, Chan WM, Ip JD, Cai JP, Cheng VCC, Chen H, Hui CKM, Yuen KY. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020 15-21 February; 395(10223): 514–523.

8. Mok CC, Chan KH, Ling Yin Ho, Fung YF, Fung WF, Woo PCY. Safety and immune response of a live-attenuated herpes zoster vaccine in patients with systemic lupus erythematosus: a randomised placebo-controlled. Ann Rheum Dis. 2019 Sep 17.

9. Chan KH, To KKW, Li PTW, Wong TL, Zhang R, Chik KKH, Chan G, Yip CCY, Chen HL, Hung IFN, Chan JFW, Yuen KY. Evaluation of NxTAG Respiratory Pathogen Panel and Comparison with xTAG Respiratory Viral Panel Fast v2 and Film Array Respiratory Panel for Detecting Respiratory Pathogens in Nasopharyngeal Aspirates and Swine/Avian-Origin Influenza A Subtypes in Culture Isolates. Adv Virol. 2017; 2017: 1324276.

10. Yeung ML, Yao Y, Jia L, Chan JFW, Chan KH, Cheung KF, Chen H, Vincent K. M. Poon VKM, Tsang AKL, To KKW, Yiu MK, Teng JLL, Chu H, Zhou J, Zhang Q, Deng W, Lau SKP, Lau JYN, Woo PCY, Chan TM, Yung S, Zheng BJ, Jin DY, Mathieson PW, Qin C and Yuen KY. MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2. Nat Microbiol. 2016; 1:16004.

11. Hung IF, Zhang AJ, To KKW, Chan JFW, Li P, Wong TL, Zhang R, Chan TC, Chan BY, Ho Wai HH, Chan LW, Fong HPY, Hui RKC, Kong KL, Leung ACF, Ngan AHT, Tsang LWK, Yeung APC, Yiu GCC, Yung W, Lau JYN, Chen H, Chan KH, Yuen KY. Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial. Lancet Infect Dis. 2016, 16:209-18.

12. Lu L, Liu Q, Zhu Y, Chan KH, Qin L, Li Y, Wang Q, Chan JFW, Du L, Yu F, Ma C, Ye S, Yuen KY, Zhang R, Jiang S. Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor. Nat Commun. 2014; 5:3067.

13. Cowling BJ, Chan KH, Feng S, Chan EL, Lo JY, Peiris JS, Chiu SS. The effectiveness of influenza vaccination in preventing hospitalizations in children in Hong Kong, 2009-2013. Vaccine. 2014; 32(41):5278-84.

14. Hung IF, Zhang AJ, To KK, Chan JF, Li C, Zhu HS, Li P, Li C, Chan TC, Cheng VC, Chan KH, Yuen KY. Immunogenicity of Intradermal Trivalent Influenza Vaccine with Topical Imiquimod, a Double Blind Randomized Controlled Trial. Clin Infect Dis. 2014 Jul 21.

15. Ho PL, Sin WC, Chan JF, Cheng VC, Chan KH. Severe influenza A H7N9 pneumonia with rapid virological response to intravenous zanamivir. Eur Respir J. 2014; 44(2):535-7.

16. Chan KH, To KK, Chan JF, Li CP, Chan KM, Chen H, Ho PL, Yuen KY. Assessment of antigen and molecular tests in serial specimens from a patient with influenza A (H7N9) infection. J Clin Microbiol. 2014; 52(6):2272-4.

17. Woo PC, Lau SK, Wernery U, Wong EY, Tsang AK, Johnson B, Yip CC, Lau CC, Sivakumar S, Cai JP, Fan RY, Chan KH, Mareena R, Yuen KY. Novel betacoronavirus in dromedaries of the middle East, 2013. Emerg Infect Dis. 2014; 20(4):560-72.

18. LU L, Liu Q, Zhu Y, Chan KH, Qin L, Li Y, Wang Q, Chan JF, Du L, Yu F, Ma C, Ye S, Yuen KY, Zhang R, Jiang S. Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor. Nat Commun. 2014; 5:3067.

19. Chen Y, Liang W, Yang S, Wu N, Gao H, Sheng J, Yao H, Wo J, Fang Q, Cui D, Li Y, Yao X, Zhang Y, Wu H, Zheng S, Diao H, Xia S, Zhang Y, Chan KH, Tsoi HW, Teng JLL, Song W, Wang P, Lau SY, Zheng M, Chan JFW, To KKW, Chen H, Li L, Yuen KY. Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome. Lancet. 2013, 381:1916-25

20. Chan JF, Chan KH, Kao RY, To KK, Zheng BJ, Li CP, Li PT, Dai J, Mok FK, Chen H, Hayden FG, Yuen KY. Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus. J Infect. 2013; 67(6):606-16

21. Chan KH, To KK, Chan JF, Li CP, Chen H, Yuen KY. Analytical Sensitivity of Seven Point-of-Care Influenza Virus Detection Tests and Two Molecular Tests for Detection of Avian Origin H7N9 and Swine Origin H3N2 Variant Influenza A Viruses. J Clin Microbiol. 2013; 51(9):3160-1.

22. Chan KH, To KK, Chan BW, Li CP, Chiu SS, Yuen KY, Ho PL. Comparison of pyrosequencing, Sanger sequencing, and melting curve analysis for detection of low-frequency macrolide-resistant mycoplasma pneumoniae quasispecies in respiratory specimens. J Clin Microbiol. 2013; 51(8):2592-8.

23. Chen Y, Liang W, Yang S, Wu N, Gao H, Sheng J, Yao H, Wo J, Fang Q, Cui D, Li Y, Yao X, Zhang Y, Wu H, Zheng S, Diao H, Xia S, Zhang Y, Chan KH, Tsoi HW, Teng JL, Song W, Wang P, Lau SY, Zheng M, Chan JF, To KK, Chen H, Li L, Yuen KY. Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome. Lancet. 2013; 381(9881):1916-25.

24. Chan KH, Fuk-Woo Chan J, Tse H, Chen H, Choi-Yi Lau C, Cai JP, Ka-Lun Tsang A, Xiao X, Kai-Wang To K, Kar-Pui Lau S, Chiu-Yat Woo P, Zheng BJ, Wang M, Yuen KY. Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests. J Infect. 2013; 67(2):130-40.

25. Chan KH, Yan MK, To KK, Lau SK, Woo PC, Cheng VC, Li WS, Chan JF, Tse H, Yuen KY. Use of the human colorectal adenocarcinoma (Caco-2) cell line for isolating respiratory viruses from nasopharyngeal aspirates. J Med Virol. 2013; 85(5):874-9.

26. Hung IF, To KK, Lee CK, Lee KL, Yan WW, Chan K, Chan WM, Ngai CW, Law KI, Chow FL, Liu R, Lai KY, Lau CC, Liu SH, Chan KH, Lin CK, Yuen KY. Hyperimmune Intravenous Immunoglobulin Treatment: A Multicentre Double-Blind Randomized Controlled Trial for Patients with Severe A(H1N1)pdm09 Infection. Chest. 2013;144(2):464-73.

27. To KK, Hung IF, Xu T, Poon RW, Ip WC, Li PT, Li CP, Lau SK, Yam WC, Chan KH, Yuen KY. Clinical significance of Pneumocystis jiroveci in patients with active tuberculosis. Diagn Microbiol Infect Dis. 2013; 75(3):260-5.

28. Chan KH, Chan KM, Ho YL, Lam YP, Tong HL, Poon LL, Cowling BJ, Peiris JS. Quantitative analysis of four rapid antigen assays for detection of pandemic H1N1 2009 compared with seasonal H1N1 and H3N2 influenza A viruses on nasopharyngeal aspirates from patients with influenza. J Virol Methods. 2012; 186:184-188

29. Lau SK, Yip CC, Lung DC, Lee P, Que TL, Lau YL, Chan KH, Woo PC, Yuen KY. Detection of human rhinovirus C in fecal samples of children with gastroenteritis. J Clin Virol. 2012; 53(4):290-6.

30. Smith C, Tsang J, Beagley L, Chua D, Lee V, Li V, Moss DJ, Coman W, Chan KH, Nicholls J, Kwong D, Khanna R. Effective treatment of metastatic forms of Epstein-Barr virus-associated nasopharyngeal carcinoma with a novel adenovirus-based adoptive immunotherapy. Cancer Res. 2012; 72(5):1116-25.

31. Bahl J, Nelson MI, Chan KH, Chen R, Vijaykrishna D, Halpin RA, Stockwell TB, Lin X, Wentworth DE, Ghedin E, Guan Y, Peiris JS, Riley S, Rambaut A, Holmes EC, Smith GJ. Temporally structured metapopulation dynamics and persistence of influenza A H3N2 virus in humans. Proc Natl Acad Sci U S A. 2011; 108(48):19359-64.

32. Ning RJ, Xu XQ, Chan KH, Chiang AK. Long-term carriers generate Epstein-Barr virus (EBV)-specific CD4(+) and CD8(+) polyfunctional T-cell responses which show immunodominance hierarchies of EBV proteins. Immunology. 2011; 134(2):161-71.

33. Chan KH, Peiris JS, Lam SY, Poon LL, Yuen KY, Seto WH. The Effects of Temperature and Relative Humidity on the Viability of the SARS Coronavirus. Adv Virol. 2011; 2011:734690

34. Chu DK, Chin AW, Smith GJ, Chan KH, Guan Y, Peiris JS, Poon LL. Detection of novel astroviruses in urban brown rats and previously known astroviruses in humans. J Gen Virol. 2010; 91(Pt 10):2457-62.

35. Cowling BJ, Chan KH et al., Comparative Epidemiology of Pandemic and Seasonal Influenza A in Households. N Engl J Med. 2010; 362:2175-2184

36. Chan KH, Lai ST, Poon LL, Guan Y, Yuen KY, Peiris JS. Analytical sensitivity of rapid influenza antigen detection tests for swine-origin influenza virus (H1N1). J Clin Virol. 2009; 45:205-7.

37. Chan KH, Yam WC, Pang CM, Chan KM, Lam SY, Lo KF, Poon LL, Peiris MJ. Comparsion of the NucliSens easyMAG and Qiagen BioRobot 9604 nucleic acid extraction systems for diagnosis of RNA and DNA respiratory viruses on nasopharyngeal aspirates. J Clin Microbiol. 2008; 46:2195-9.

38. Chan KH, Peiris JS, Lim W, Nicholls JM, Chiu SS. Comparison of nasopharyngeal flocked swabs and aspirates for rapid diagnosis of respiratory viruses in children. J Clin Virol. 2008; 42:65-9

39. Ji MF, Wang DK, Yu YL, Guo YQ, Liang JS, Cheng WM, Zong YS, Chan KH, Ng SP, Wei WI, Chua DT, Sham JS, Ng MH. Sustained elevation of Epstein-Barr virus antibody levels preceding clinical onset of nasopharyngeal carcinoma. Br J Cancer. 2007; 96:623-30.

40. Chan VS, Chan KY, Chen Y, Poon LL, Cheung AN, Zheng B, Chan KH, Mak W, Ngan HY, Xu X, Screaton G, Tam PK, Austyn JM, Chan LC, Yip SP, Peiris M, Khoo US, Lin CL. Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection. Nat Genet. 2006; 38:38-46.

41. Kandun IN, Wibisono H, Sedyaningsih ER, Yusharmen, Hadisoedarsuno W, Purba W, Santoso H, Septiawati C, Tresnaningsih E, Heriyanto B, Yuwono D, Harun S, Soeroso S, Giriputra S, Blair PJ, Jeremijenko A, Kosasih H, Putnam SD, Samaan G, Silitonga M, Chan KH, Poon LL, Lim W, Klimov A, Lindstrom S, Guan Y, Donis R, Katz J, Cox N, Peiris M, Uyeki TM. Three Indonesian clusters of H5N1 virus infection in 2005. N Engl J Med. 2006; 355:2186-94.

42. Chan KH, Cheng VC, Woo PC, Lau SK, Poon LL, Guan Y, Seto WH, Yuen KY, Peiris JS. Serological responses in patients with severe acute respiratory syndrome coronavirus infection and cross-reactivity with human coronaviruses 229E, OC43, and NL63. Clin Diagn Lab Immunol. 2005; 12:1317-21.

43. Leung AY, Chan MT, Yuen KY, Cheng VC, Chan KH, Wong CL, Liang R, Lie AK, Kwong YL. Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation. Clin Infect Dis. 2005; 40:528-37.

44. Chan KH, Poon LL, Cheng VC, Guan Y, Hung IF, Kong J, Yam LY, Seto WH, Yuen KY, Peiris JS. Detection of SARS coronavirus in patients with suspected SARS. Emerg Infect Dis. 2004; 10:294-9.

45. Haagmans BL, Kuiken T, Martina BE, Fouchier RA, Rimmelzwaan GF, van Amerongen G, van Riel D, de Jong T, Itamura S, Chan KH, Tashiro M, Osterhaus AD. Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques. Nat Med. 2004; 10:290-3.

46. Chan KH, Gu YL, Ng F, Ng PS, Seto WH, Sham JS, Chua D, Wei W, Chen YL, Luk W, Zong YS, Ng MH. EBV specific antibody-based and DNA-based assays in serologic diagnosis of nasopharyngeal carcinoma. Int J Cancer. 2003; 105:706-9.

47. Peiris JS, Lai ST, Poon LL, Guan Y, Yam LY, Lim W, Nicholls J, Yee WK, Yan WW, Cheung MT, Cheng VC, Chan KH, Tsang DN, Yung RW, Ng TK, Yuen KY; SARS study group. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003; 361:1319-25.

48. Chan KH, Maldeis N, Pope W, Yup A, Ozinskas A, Gill J, Seto WH, Shortridge KF, Peiris JS. Evaluation of the Directigen FluA+B test for rapid diagnosis of influenza virus type A and B infections. J Clin Microbiol. 2002; 40:1675-80.

49. Chan KH, Ng MH, Seto WH, Peiris JS. Epstein-Barr virus (EBV) DNA in sera of patients with primary EBV infection. J Clin Microbiol. 2001; 39:4152-4.

50. Chan KH, Luo RX, Chen HL, Ng MH, Seto WH, Peiris JS. Development and evaluation of an Epstein-Barr virus (EBV) immunoglobulin M enzyme-linked immunosorbent assay based on the 18-kilodalton matrix protein for diagnosis of primary EBV infection. J Clin Microbiol. 1998; 36:3359-61.



1. Being named as one of the world’s most highly cited researchers (3000) in science 2015 by Thomas Reuters

2. Outstanding Teams Award (HA): H5N1 (1999), swine H1N1 (2010) and SARS (2003). Awarded by the Hospital Authority.

3. Cancer Research Fellow, International Union Against Cancer (UICC), USA (1988)