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Dr. Kong Hung SZE
BSc, PhD PhD Scientific Officer, Department of Microbiology
Email: khsze@hku.hk
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Research Interests:
» Structural
Biology of virulent factors of Penicillium marneffei, and other emerging human
pathogens
Selected publications:
1. Backbone and side-chain (1)H, (13)C and (15)N
assignments of the PPIase domain of macrophage infectivity potentiator (Mip)
protein from Coxiella burnetii; Man-Kit Tse, Stanley K K Cheung, Yi-Hong Ke,
Candy C Y Lau, Kong-Hung Sze*, Kwok-Yung Yuen; Biomolecular NMR
Assignments 04/2013; DOI:10.1007/s12104-013-9477-3.
2. Domain Organization of XAF1 and the Identification and
Characterization of XIAP(RING) -binding Domain of XAF1, Man Kit Tse, Chi Kong
Cho, Wai Fung Wong, Bing Zou, Sin Kam Hui, Benjamin Chun Yu Wong and Kong
Hung Sze*, 2012, Protein Sci. (2012) 21(10):1418-1428.
3. Solution structure of the dimerization domain of the
eukaryotic stalk P1/P2 complex reveals the structural organization of eukaryotic
stalk complex, Ka-Ming Lee, Conny Wing-Heng Yu, Teddy Yu-Hin Chiu, Kong-Hung
Sze, Pang-Chui Shaw, Kam-Bo Wong, Nucleic Acids Research. (2012)
40:3172-3182.
4. Structural Analysis of the UBA Domain of X-linked
Inhibitor of Apoptosis Protein Reveals Different Surfaces for Ubiquitin-binding
and Self-association, Man-Kit Tse, Sin-Kam Hui, Yinhua Yang , SinTao Yin, HongYu
Hu, Bing Zou, Benjamin Chun-Yu Wong and Kong-Hung Sze*; PLoS One, 6
(2011) e28511.
5. Goldfish Spexin: Solution Structure and Novel Function
as a Satiety Factor in Feeding Control.; Matthew K H Wong, Kong Hung Sze,
Ting Chen, Chi Kong Cho, Henry C H Law, Ivan K Chu, Anderson O L Wong; AJP
Endocrinology and Metabolism. 05/2013; DOI:10.1152/ajpendo.00141.2013.
6. Maize Ribosome-Inactivating Protein Uses Lys158-Lys161
to Interact with Ribosomal Protein P2 and the Strength of Interaction Is
Correlated to the Biological Activities, Wong, Yuen-Ting; Ng, Yiu-Ming; Mak,
Amanda Nga-Sze; Sze, Kong-Hung; Wong, Kam-Bo; Shaw, Pang-Chui; PLoS One,
7(2012) e49608.
7. Production of 2-aminophenoxazine-3-one by
Staphylococcus aureus causes false-positive results in G]-galactosidase assay,
Herman Tse, Elaine Chan, Ching-Wan Lam, Ka-Fai Leung, Pat Chow, Kim-Chung Lee,
Kong-Hung Sze, Stanley K K Cheung, Man-Kit Tse, Pak-Leung Ho, Sze-Pui
Leung, Susanna K P Lau, Patrick C Y Woo, Kwok-Yung Yuen, J Clin Microbiol.
(2012) 50(11):3780-3782.
8. Transport genes and chemotaxis in Laribacter
hongkongensis: a genome-wide analysis, Susanna KP Lau, Rachel YY Fan, Gilman KM
Wong, Jade LL Teng, Kong-Hung Sze, Herman Tse, Kwok-Yung Yuen and Patrick
CY Woo, Cell & Bioscience (2011) 1:28.
9. Backbone and side-chain 1H, 13C and 15N resonance
assignments of resonance assignments of S18Y mutant of Ubiquitin
carboxy-terminal hydrolase L1, Ho-Sum Tse , Hong-Yu Hu and Kong-Hung Sze*;
J. Biomol. NMR Assignments, 5 (2011) 165-168.
10. Structural basis and sequence co-evolution analysis of
the hemagglutinin protein of pandemic influenza A/H1N1 (2009) virus, Herman Tse,
Richard YT Kao, Wai Lan Wu,Wilina W. L. Lim, Honglin Chen, Ming Yiu Yeung,
Patrick CY Woo, Kong-Hung Sze*, Kwok-Yung Yuen*; Experimental Biology and
Medicine, 236 (2011) 915-925.
11. Isolation and characterization of antimicrobial,
anti-inflammatory and chemopreventive flavones from Premna odorata Blanco.; by
LC Pinzon, MM Uy, KH Sze, MF Wang and IK Chu; J. of Medicinal Plants
Research, 5 (2011) 2729-2735.
12. Probing Protein Dynamics by Nuclear Magnetic
Resonance, Kong-Hung Sze*, Pok Man Lai; Protein & Peptide Letters, 18
(2011) 373-379.
13. Structural characterization and anti-HIV-1 activities
of arginine/glutamate-rich polypeptide Luffin P1 from the seeds of sponge gourd
(Luffa cylindrica), Yiu-Ming Ng, Yinhua Yang, Kong Hung Sze, Xuan Zhang,
Yong-Tang Zheng and Pang-Chui Shaw; J. Structural Biology, 174 (2011) 164-172.
14. A Rigidifying Salt-Bridge Favors the Activity of
Thermophilic Enzyme at High Temperatures at the Expense of Low-Temperature
Activity.; by SY Lam, RCY Yeung, TH Yu, Kong-Hung Sze, Kam-Bo Wong; PLoS
Biology, 9 (3) e1001027.
15. Solution structure of the N-terminal domain of
DC-UbP/UBTD2 and its interaction with ubiquitin; by Ai-Xin Song, Chen-Jie Zhou,
Xiao Guan,
Kong-Hung Sze and Hong-Yu Hu; Protein Science, 19 (2010) 1104-1109.
16. Solution structure of the dimerization domain of
ribosomal protein P2 provides insights for the structural organization of
eukaryotic stalk, Lee, Ka-Ming, Yu, Conny Wing-Heng, Chan, Denise So-Bik), Chiu,
Teddy Yu-Hin, Zhu, Guang, Sze, Kong-Hung, Shaw, Pang-Chui, Wong, Kam-Bo;
Nucleic Acids Research, 38 (2010) 5206-5216.
17. Identification of a Nonaketide Product for the
Iterative Polyketide Synthase in Biosynthesis of the Nine-Membered Enediyne
C-1027; Xiaolei Chen, ZF Guo, PM Lai, Kong Hung Sze* and Zhihong Guo*,
Angew. Chem. Int. Ed. Engl., 49 (2010) 7926-7928.
18. Structure of a Nickel Chaperone, HypA from
Helicobacter pylori Reveals Two Distinct Metal Binding Sites, Xia, Wei; Li,
Hongyan; Sze, Kong Hung; Sun, Hongzhe, J. Am. Chem. Soc. 131 (2009)
10031-10040.
19. The Kringle 1 Domain of Hepatocyte Growth Factor Has
Antiangiogenic and Antitumor Cell Effects on Hepatocellular Carcinoma, Zan Shen,
Zhen Fan Yang, Yi Gao, Cheng Li, Hai Xiao Chen, Ching Chiu Liu, Ronnie T.P.
Poon, Sheung Tat Fan, John M. Luk, Kong Hung Sze, Tsai Ping Li, Ren Bao
Gan, Ming Liang He, Hsiang Fu Kung, and Marie C.M. Lin, Cancer Research, 68
(2008) 404-414.
20. Pituitary Adenylate Cyclase-Activating Polypeptide
(PACAP) as a Growth Hormone (GH) -Releasing Factor in Grass Carp: II. Solution
Structure of a Brain-Specific PACAP by Nuclear Magnetic Resonance Spectroscopy
and Functional Studies on GH Release and Gene Expression, Kong Hung Sze,
Hong Zhou, Yinhua Yang, Mulan He, Yonghua Jiang and Anderson O. L. Wong,
Endocrinology 148 (2007) 5042-5059.
21. Interaction between trichosanthin, a
ribosome-inactivating protein, and the ribosomal stalk protein P2 by chemical
shift perturbation and mutagenesis analyses, Denise S.B. Chan, Lai-On Chu,
Ka-Ming Lee, Priscilla H.M. Too, Kit-Wan Ma, Kong-Hung Sze, Guang Zhu,
Pang-Chui Shaw, and Kam-Bo Wong, Nucleic Acids Research, 35 (2007) 1660-1672.
22. Functional studies of the small subunit of EcoHK31I
DNA methyltransferase!!L, Wai-To Fung, Kong-Hung Sze, Kai-Fai Lee and
Pang-Chui Shaw, Biological Chemistry, 387 (2006) 507-513.
23. Letter to the Editor: NMR structure note - Solution
structure of a bacterial BolA-like protein XC975 from a plant pathogen
Xanthomonas campestris pv. campestris, by KH Chin , FY Lin , YC Hu , KH Sze
, PC Lyu , SH Chou , J. Biomol NMR, 31 (2005) 167-172.
24. Elucidation of Solution Conformations of Loloatin C by
NMR Spectroscopy and Molecular Simulation, by H. Chen, R.K. Haynes, J.
Scherkenbeck, K.H. Sze and G. Zhu, Eur. J. Org. Chem., 2004 (2004) 31-37.
25. Effects of domain dissection on the folding and
stability of the 43 kDa protein PGK probed by NMR, by Reed MAC, Hounslow AM,
Sze KH, Barsukov IG, Hosszu LLP, Clarke AR, Craven CJ, Waltho JP, J. Mol.
Bio., 330 (2003) 1189-1201.
26. Solution structure of the C-terminal domain of the
ciliary neurotrophic factor (CNTF) receptor and ligand free associations among
components of the CNTF receptor complex", by Man D, He W, Sze KH, Gong K,
Smith DK, Zhu G, Ip NY, J. Biol. Chem., 278 (2003) 23285-23294.
27. Clean SEA-HSQC: A method to map solvent exposed amides
in large non-deuterated proteins with gradient-enhanced HSQC, by D.H. Lin,
K.H. Sze, Y.F. Cui and G. Zhu, J. Biomol. NMR, 23 (2002) 317-322.
28. Mapping the Binding Site for the GTP-binding Protein
Rac-1 on its Inhibitor RhoGDI-1, by L.-Y Lian, I.L. Barsukov, A.P. Golovanov,
D.I. Hawkins, R. Badii, K.H. Sze, N.H. Keep, G.M. Bokoch and G.C.K.
Roberts, Structure 8 (2000) 47-55.
29. Protein Dynamics Measurements by TROSY-Based NMR
Experiments, by Y.L. Xia, G. Zhu, L.K. Nicholson and K.H. Sze, J. Magn.
Reson., 143 (2000) 423-426.
30. Gradient and sensitivity enhancement of 2D TROSY with
water flip-back, 3D NOESY-TROSY and TOCSY-TROSY experiments, by G. Zhu, X.M.
Kong and K.H. Sze, J. Biomol. NMR, 13 (1999) 77-81.
31. Direct Measurement of the pKa of Aspartic Acid 26 in
Lactobacillus casei Dihydrofolate Reductacse: Implications for the Catalytic
Mechanism, by M.G. Cassarotto, J. Basran, R. Badii, K.H. Sze and G.C.K.
Roberts, Biochemistry, 38 (1999) 8038-8044.
32. Sensitivity Enhancement in Transverse Relaxation
Optimized NMR Spectroscopy", by G. Zhu, X.M. Kong, X.Z. Yan & K.H. Sze,
Angew. Chem. Int. Ed. Engl., 37 (1998) 2859-2861. 33. The conformation of coenzyme A bound to chloramphenicol acetyltransferase determined by transferred NOE experiments", by I.L. Barsukov, L.Y. Lian, J. Ellis, K.H. Sze, W.V. Shaw and G.C.K. Roberts, J. Mol. Biol, 262 (1996) 543-558. |
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