KOK Kin-Hang (郭健恒), Dr.

 

PhD

Associate Professor(Non-Clinical), Department of Microbiology


Email: khkok@hku.hk

 

Personal Website: http://web.hku.hk/~khkok

 

ORCID : https://orcid.org/0000-0003-3426-332X

 

 

Research Interests

Molecular mechanism of innate immunity:

Interferon signaling and Interferon-stimulated genes

 

Virus-host interaction:

MERS-CoV and influenza A virus

 

Selected Publications

Chan JF, Yuan S, Kok* KH, To KK, Chu H, Yang J, Xing F, Liu J, Yip CC, Poon RW, Tsoi HW, Lo SK, Chan KH, Poon VK, Chan WM, Ip JD, Cai JP, Cheng VC, Chen H, Hui CK, Yuen KY. (2020) A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 395:514-523. (*: co-first author) (IF: 59.102)

Chan JF, Kok* KH, Zhu Z, Chu H, To KK, Yuan S, Yuen KY. (2020) Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect. 9:221-236. (*: co-first and co-corresponding author) (IF: 6.212)

Lee AC, Zhang AJ, Chu H, Li C, Zhu H, Mak WW, Chen Y, Kok KH, To KK, Yuen KY. (2019) H7N9 influenza A virus activation of necroptosis in human monocytes links innate and adaptive immune responses. Cell Death and Disease 10:442.

Lui, WY, Yuen CK, Li C, Wong WM, Lui PY, Lin CH, Chan KH, Zhao H, Chen H, To KK, Zhang AJ, Yuen KY, Kok KH. (2019) SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection. Emerging Microbes & Infections 8:662-674.

Zhu Z, Chu H, Wen L, Yuan S, Chik KK, Yuen TT, Yip CC, Wang D, Zhou J, Yin F, Jin DY, Kok KH, Yuen KY, Chan JF. (2019) Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy. Int J Mol Sci. 20. pii: E392.

Yuan S, Chu H, Chan JF, Ye ZW, Wen L, Yan B, Lai PM, Tee KM, Huang J, Chen D, Li C, Zhao X, Yang D, Chiu MC, Yip C, Poon VK, Chan CC, Sze KH, Zhou J, Chan IH, Kok KH, To KK, Kao RY, Lau JY, Jin DY, Perlman S, Yuen KY. (2019) SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target. Nat Commun. 10:120.

Lau SKP, Fan RYY, Luk HKH, Zhu L, Fung J, Li KSM, Wong EYM, Ahmed SS, Chan JFW, Kok RKH, Chan KH, Wernery U, Yuen KY, Woo PCY. (2018) Replication of MERS and SARS coronaviruses in bat cells offers insights to their ancestral origins. Emerg Microbes Infect. 7:209.

Yeung ML, Jia L, Yip CCY, Chan JFW, Teng JLL, Chan KH, Cai JP, Zhang C, Zhang AJ, Wong WM, Kok KH, Lau SKP, Woo PCY, Lo JYC, Jin DY, Shih SR, Yuen KY. (2018) Human tryptophanyl-tRNA synthetase is an IFN-γ-inducible entry factor for Enterovirus. J Clin Invest. 128:5163-5177.

Wang PH, Ye ZW, Deng JJ, Siu KL, Gao WW, Chaudhary V, Cheng Y, Fung SY, Yuen KS, Ho TH, Chan CP, Zhang Y, Kok KH, Yang W, Chan CP, Jin DY. (2018) Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16. EMBO Rep. 19. pii: e45737

Zhao H, To KK, Chu H, Ding Q, Zhao X, Li C, Shuai H, Yuan S, Kok KH, Jiang S, Yuen KY. (2018) Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza. Nat Commun. 9:2358.

Guo Q, Chan JF, Poon VK, Wu S, Chan CC, Hou L, Yip CC, Ren C, Cai JP, Zhao M, Zhang AJ, Song X, Chan KH, Wang B, Kok KH, Wen Y, Yuen KY, Chen W. (2018) Immunization with a Novel Human type 5 Adenovirus-Vectored Vaccine Expressing the Premembrane and Envelope Proteins of Zika Virus Provides Consistent and Sterilizing Protection in Multiple Immunocompetent and Immunocompromised Animal Models. J Infect Dis.218:365-377.

Wang PH, Fung SY, Gao WW, Deng JJ, Cheng Y, Chaudhary V, Yuen KS, Ho TH, Chan CP, Zhang Y, Kok KH, Yang W, Chan CP, Jin DY. (2018) A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing. Nucleic Acids Res. 46:4054-4071.

Chan CP, Yuen CK, Cheung PH, Fung SY, Lui PY, Chen H, Kok* KH, Jin DY. (2018) Antiviral activity of double-stranded RNA-binding protein PACT against influenza A virus mediated via suppression of viral RNA polymerase. FASEB J. 32:4380-4393. (*: co-corresponding author)

Lau SKP, Zhang L, Luk HKH, Xiong L, Peng X, Li KSM, He X, Zhao PS, Fan RYY, Wong ACP, Ahmed SS, Cai JP, Chan JFW, Sun Y, Jin D, Chen H, Lau TCK, Kok KH, Li W, Yuen KY, Woo PCY. (2018) Receptor usage of a novel bat lineage C betacoronavirus reveals evolution of MERS-related coronavirus spike proteins for human DPP4 binding. J Infect Dis. 218:197-207

Lui PY, Wong LR, Ho TH, Au SWN, Chan CP, Kok* KH, Jin DY. (2017) PACT Facilitates RNA-Induced Activation of MDA5 by Promoting MDA5 Oligomerization. J Immunol. 199:1846-55. (*: co-corresponding author)

Chaudhary V, Yuen KS, Chan JF, Chan CP, Wang PH, Cai JP, Zhang S, Liang MF, Kok KH, Chan CP, Yuen KY, Jin DY (2017) Selective activation of Type II Interferon signaling by Zika virus NS5 protein. J Virol. 96:3204-11.

Cheung NN, Lai KK, Dai J, Kok KH, Chen H, Chan KH, Yuen KY, Kao R. (2017) Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response. J Gen Virol. 98:946-54.

Yuen KS, Chan CP, Kok KH, Jin DY. (2017) Mutagenesis and Genome Engineering of Epstein - Barr virus in Cultured Human Cells by CRISPR/Cas9. Methods Mol Biol. 1498:23-31.

Chan JF, Zhang AJ, Chan CC, Yip CC, Mak WW, Zhu H, Poon VK, Tee KM, Zhu Z, Cai JP, Tsang JO, Chik KK, Yin F, Chan KH, Kok KH, Jin DY, Au-Yeung RK, Yuen KY. (2016) Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons. EBioMedicine. 14:112-122.

Chan JF, Yip CC, Tsang JO, Tee KM, Cai JP, Chik KK, Zhu Z, Chan CC, Choi GK, Sridhar S, Zhang AJ, Lu G, Chiu K, Lo AC, Tsao SW, Kok KH, Jin DY, Chan KH, Yuen KY. (2016) Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs. Emerg Microbes Infect. 5:e93.

Yuen CK, Chan CP, Fung SY, Wang PH, Wong WM, Tang HM, Yuen KS, Chan CP, Jin DY, Kok KH. (2016) Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation. J Virol. 90:3902-12.

Ho TH, Kew C, Lui PY, Chan CP, Satoh T, Akira S, Jin DY, Kok KH. (2015) PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine. J Virol. 90:1557-68.

Chaudhary V, Zhang S, Yuen KS, Li C, Lui PY, Fung SY, Wang PH, Chan CP, Li D, Kok KH, Liang M, Jin DY. (2015) Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation. J Gen Virol. 96:3204-11.

Yuen KS, Chan CP, Wong NH, Ho CH, Ho TH, Lei T, Deng W, Tsao SW, Chen H, Kok* KH, Jin DY. (2014) CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells. J Gen Virol. 96:626-36. (*: co-corresponding author)

Lee SMY, Kok KH, Jaume M, Cheung TKW, Yip TF, Lai JCC, Guan Y, Webster RG, Jin DY, Peiris JSM. (2014) Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection. Proc Natl Acad Sci USA 111:3793-8.

Siu* KL, Yeung* ML, Kok* KH, Yuen KS, Kew C, Lui PY, Chan CP, Tse H, Woo PC, Yuen KY, Jin DY. (2014) Middle East respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in innate antiviral response. J Virol 88:4866-4876. (*: co-first author)

Siu KL, Chan CP, Kok KH, Woo PCY, Jin DY. (2014) Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain. Cell Mol Immunol 11:141-149.

Kew C, Lui PY, Chan CP, Au WN, Mohr I, Jin DY, Kok KH. (2013) Suppression of PACT-induced type I interferon production by herpes simplex virus type 1 Us11 protein. J Virol 87:13141-13149.

Lei T, Yuen KS, Tsao SW, Chen H, Kok KH, Jin DY. (2013) Perturbation of biogenesis and targeting of Epstein-Barr virus-encoded miR-BART3 microRNA by adenosine-to-inosine editing. J Gen Virol 12:2739-2744.

Kok KH, Jin DY. (2013) Balance of power in host-virus arms races. Cell Host Microbe 14:5-6.

Kok KH, Lui PY, Ng MHJ, Siu KL, Au SWN, Jin DY. (2011) The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response. Cell Host Microbe 9:299-309.

  

Editorship:

Academic Editor, PLoS ONE (2010 - present)