Shuofeng Yuan, PhD, DVM

 

Assistant Professor, Department of Microbiology


Email: yuansf@hku.hk

 

ORCID : https://orcid.org/0000-0001-7996-1119

 

Pubmed : https://pubmed.ncbi.nlm.nih.gov/

 

 

Research Interests

1. Host-targeting antiviral development with a focus on metabolic/lipidomic reprogramming.

 

2. Broad-spectrum antiviral development against emerging viruses including Coronaviruses, and Influenza A viruses etc.

 

Selected Publications:

1.      Yuan S, Yin X, Meng X, Chan JF, Ye ZW, Riva L, Pache L, Chan CC, Lai PM, Chan CC, Poon VK, Lee AC, Matsunaga N, Pu Y, Yuen CK, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Lau CY, Sit KY, Au WK, Wang R, Zhang YY, Tang YD, Clausen TM, Pihl J, Oh J, Sze KH, Zhang AJ, Chu H, Kok KH, Wang D, Cai XH, Esko JD, Hung IF, Li RA, Chen H, Sun H, Jin DY, Sun R, Chanda SK, Yuen KY. Clofazimine broadly inhibits coronaviruses including SARS-CoV-2. Nature. 2021 Mar 16.

 

2.     Yuan S, Wang R, Chan JF, Zhang AJ, Cheng T, Chik KK, Ye ZW, Wang S, Lee AC, Jin L, Li H, Jin DY, Yuen KY, Sun H. Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters. Nat Microbiol. 2020 Oct 7.

 

3.    Yuan S, Chu H, Huang J, Zhao X, Ye ZW, Lai PM, Wen L, Cai JP, Mo Y, Cao J, Liang R, Poon VK, Sze KH, Zhou J, To KK, Chen Z, Chen H, Jin DY, Chan JF, Yuen KY. Viruses harness YxxØ motif to interact with host AP2M1 for replication: a vulnerable broad-spectrum antiviral target. Sci Adv. 2020 Aug 28;6(35): eaba7910.

 

4.     Riva L, Yuan S* (co-first author), Yin X, Martin-Sancho L, Matsunaga N, Pache L, Burgstaller-Muehlbacher S, De Jesus PD, Teriete P, Hull MV, Chang MW, Chan JF, Cao J, Poon VK, Herbert KM, Cheng K, Nguyen TH, Rubanov A, Pu Y, Nguyen C, Choi A, Rathnasinghe R, Schotsaert M, Miorin L, Dejosez M, Zwaka TP, Sit KY, Martinez-Sobrido L, Liu WC, White KM, Chapman ME, Lendy EK, Glynne RJ, Albrecht R, Ruppin E, Mesecar AD, Johnson JR, Benner C, Sun R, Schultz PG, Su AI, García-Sastre A, Chatterjee AK, Yuen KY, Chanda SK. Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing. Nature. 2020 Oct;586(7827):113-119.

 

5.     Chan JF, Yuan S* (co-first author), Kok KH, To KK, Chu H, Yang J, Xing F, Liu J, Yip CC, Poon RW, Tsoi HW, Lo SK, Chan KH, Poon VK, Chan WM, Ip JD, Cai JP, Cheng VC, Chen H, Hui CK, Yuen KY. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020 Feb 15;395(10223):514-523.

 

6.     Yuan S, Chu H, Chan JF, Ye ZW, Wen L, Yan B, Lai PM, Tee KM, Huang J, Chen D, Li C, Zhao X, Yang D, Chiu MC, Yip C, Poon VK, Chan CC, Sze KH, Zhou J, Chan IH, Kok KH, To KK, Kao RY, Lau JY, Jin DY, Perlman S, Yuen KY. SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target. Nat Commun. 2019 Jan 10;10(1):120.

 

7.     Yuan S, Chu H, Zhang K, Ye J, Singh K, Kao RY, Chow BK, Zhou J, Zheng BJ. A Novel Small-Molecule Compound Disrupts Influenza A Virus PB2 Cap-Binding and Inhibits Viral Replication. J Antimicrob Chemother. 2016 Sep;71(9):2489-97.

 

8.     Yuan S, Chu H, Ye J, Hu M, Singh K, Chow BK, Zhou J, Zheng BJ. Peptide-Mediated Interference of PB2-eIF4G1 Interaction Inhibits Influenza A Viruses' Replication in Vitro and in Vivo. ACS Infect Dis. 2016 Jul 8;2(7):471-7.

 

9.    Yuan S, Chu H, Zhao H, Zhang K, Singh K, Chow BK, Kao RY, Zhou J, Zheng BJ. Identification of a Small-Molecule Inhibitor of Influenza Virus via Disrupting the Subunits Interaction of the Viral Polymerase. Antiviral Res. 2016 Jan;125:34-42.

 

10.  Yuan S, Zhang N, Singh K, Shuai H, Chu H, Zhou J, Chow BK, Zheng BJ. Cross-protection of Influenza A Virus Infection by a DNA Aptamer Targeting the PA Endonuclease Domain. Antimicrob Agents Chemother. 2015 Jul;59(7):4082-93.

 

Joining our team:

We welcome motivated individuals to join us as Research assistant, MPhil, PhD students or Postdoctoral researcher. Interested candidates please send a cover letter detailing your research interests and CV to Dr. Yuan (yuansf@hku.hk).