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Assistant Professor, Department of Microbiology
ORCID : https://orcid.org/0000-0001-7996-1119
Pubmed : https://pubmed.ncbi.nlm.nih.gov/?term=shuofeng+yuan&sort=date |
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Research Interests: Using state-of-the-art disease models and technologies to decipher novel antiviral targets and develop antiviral agents. 1) High-throughput drug screening; 2) Metabolic reprogramming; 3) Chemical proteomics;
Honors & Awards: 1) HKU Young Innovator Award (2023) 2) HMRF Research Fellowship (2022) 3) Highly Cited Researchers (Clarivate Analytics, 2021&2022). 4) HKU Research Output Prize (2021&2022) 5) MCE Award for Scientists Promoting Biology and Medicine Research (2021) 6) Top 10 Scientific News in Hong Kong (2020).
https://www.youtube.com/watch?v=w8uJMSYPSpE
Selected publications: 1) Yuan S*, Yin X*, Meng X*, Chan JF*, Ye ZW*, Riva L, Pache L, Chan CC, Lai PM, Chan CC, Poon VK, Lee AC, Matsunaga N, Pu Y, Yuen CK, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Lau CY, Sit KY, Au WK, Wang R, Zhang YY, Tang YD, Clausen TM, Pihl J, Oh J, Sze KH, Zhang AJ, Chu H, Kok KH, Wang D, Cai XH, Esko JD, Hung IF, Li RA, Chen H, Sun H, Jin DY, Sun R#, Chanda SK#, Yuen KY#. Clofazimine broadly inhibits coronaviruses including SARS-CoV-2. Nature. 2021 May;593(7859):418-423. 2) Riva L*, Yuan S* (co-first author), Yin X, Martin-Sancho L, Matsunaga N, Pache L, Burgstaller-Muehlbacher S, De Jesus PD, Teriete P, Hull MV, Chang MW, Chan JF, Cao J, Poon VK, Herbert KM, Cheng K, Nguyen TH, Rubanov A, Pu Y, Nguyen C, Choi A, Rathnasinghe R, Schotsaert M, Miorin L, Dejosez M, Zwaka TP, Sit KY, Martinez-Sobrido L, Liu WC, White KM, Chapman ME, Lendy EK, Glynne RJ, Albrecht R, Ruppin E, Mesecar AD, Johnson JR, Benner C, Sun R, Schultz PG, Su AI, García-Sastre A, Chatterjee AK#, Yuen KY#, Chanda SK#. Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing. Nature. 2020 Oct;586(7827):113-119. 3) Yuan S*, Ye ZW*, Liang R*, Tang K*, Zhang AJ*, Lu G*, Ong CP*, Man Poon VK, Chan CC, Mok BW, Qin Z, Xie Y, Chu AW, Chan WM, Ip JD, Sun H, Tsang JO, Yuen TT, Chik KK, Chan CC, Cai JP, Luo C, Lu L, Yip CC, Chu H, To KK, Chen H, Jin DY, Yuen KY, Chan JF. Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters. Science. 2022 Jun 23: eabn8939. 4) Chan JF*, Yuan S* (co-first author), Kok KH*, To KK*, Chu H*, Yang J, Xing F, Liu J, Yip CC, Poon RW, Tsoi HW, Lo SK, Chan KH, Poon VK, Chan WM, Ip JD, Cai JP, Cheng VC, Chen H, Hui CK, Yuen KY. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020 Jan 24. pii: S0140-6736(20)30154-9. 5) Yuan S*, Wang R*, Chan JF*, Zhang AJ, Cheng T, Chik KK, Ye ZW, Wang S, Lee AC, Jin L, Li H, Jin DY, Yuen KY#, Sun H#. Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters. Nat Microbiol. 2020 Nov;5(11):1439-1448.
Key collaborative publications: 1) Li M, Ye ZW, Tang K, Guo L, Bi W, Zhang Y, Tang YD, Rong G, Sawan M, Yin X, Sun R, Yuan S# (co-corresponding author), Dang B#. Enhanced trimeric ACE2 exhibits potent prophylactic and therapeutic efficacy against the SARS-CoV-2 Delta and Omicron variants in vivo. Cell Res. 2022 Apr 13:1-4. 2) Zuo D, Chen Y, Cai JP, Yuan HY, Wu JQ, Yin Y, Xie JW, Lin JM, Luo J, Feng Y, Ge LJ, Zhou J, Quinn RJ, Zhao SJ, Tong X, Jin DY, Yuan S# (co-corresponding author), Dai SX#, Xu M#. A hnRNPA2B1 agonist effectively inhibits HBV and SARS-CoV-2 omicron in vivo. Protein Cell. 2022 Jul 15;14(1):37-50. 3) Guo X, Cao J, Cai JP, Wu J, Huang J, Asthana P, Wong SKK, Ye ZW, Gurung S, Zhang Y, Wang S, Wang Z, Ge X, Kwan HY, Lyu A, Chan KM, Wong N, Huang J, Zhou Z, Bian ZX, Yuan S# (co-corresponding author), Wong HLX#. Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2. Nat Commun. 2022 Dec 23;13(1):7907. 4) Zhang YY, Liang R, Wang SJ, Ye ZW, Wang TY, Chen M, Liu J, Na L, Yang YL, Yang YB, Yuan S#(co-corresponding author), Yin X#, Cai XH#, Tang YD#. SARS-CoV-2 hijacks macropinocytosis to facilitate its entry and promote viral spike-mediated cell-to-cell fusion. J Biol Chem. 2022 Nov;298(11):102511. 5) Wang R, Chan JF, Wang S, Li H, Zhao J, Ip TK, Zuo Z, Yuen KY, Yuan S# (co-corresponding author), Sun H#. Orally administered bismuth drug together with N-acetyl cysteine as a broad-spectrum anti-coronavirus cocktail therapy. Chem Sci. 2021 Dec 3;13(8):2238-2248.
Joining our team: We welcome motivated individuals to join us as Research Assistant, MPhil, PhD students or Postdoc Fellow. Interested candidates please send a cover letter detailing your research interests and CV to Dr. Yuan (yuansf@hku.hk).
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