Dr. Siddharth Sridhar

 

Clinical Assistant Professor, Department of Microbiology


Email: sid8998@hku.hk

 

ORCID : https://orcid.org/0000-0002-2022-8307

 

 

Research Interests

Dr Sridhar is a clinical virologist with a special interest in emerging infectious diseases and hepatitis E virus. In 2018, he led the investigation which discovered that rat hepatitis E virus can cause human infection. Since then, he has conducted community-wide investigations into the genomic epidemiology, zoo-epidemiology, and clinical features of this novel pathogen. He is currently interested in developing optimal management strategies for infected patients and affected communities using innovative techniques bridging field, bedside, and laboratory. His research is focused on probing the antigenicity of rat hepatitis E virus with the specific objective of designing accurate diagnostic tests, optimizing antiviral regimens for treating infected patients, and developing vaccines against the virus using innovative small animal models.


Dr Sridhar has also discovered that genotype 4 hepatitis E virus, the most prevalent genotype of hepatitis E in China, is transmissible via organ donations and can cause treatment-refractory chronic hepatitis in transplant recipients. He is interested in uncovering the genetic mechanisms of ribavirin resistance in genotype 4 hepatitis E virus and validating these mechanisms using infectious clones.


Besides hepatitis E, Dr Sridhar has been involved in path breaking research into COVID-19 including animal models, serosurveillance studies, diagnostic tests, infection control, and clinical symptomatology that crystallized our understanding of SARS-CoV-2 in the early days of the pandemic. Dr Sridhar is also passionate about knowledge exchange and enjoys regular engagement with the public via mainstream media outlets, social media, and talks.

 

 

Selected first-author publications

1.    Sridhar S (first author), et al. Multimodal investigation of rat hepatitis E virus antigenicity: implications for infection, diagnostics, and vaccine efficacy. J Hepatol 2021; 74(6): 1315 – 1324. [IF: 25.083, Journal rank: 2/92 in Gastroenterology & Hepatology]

2.    Sridhar S (first and corresponding author), et al. Hepatitis E virus species C infection in humans, Hong Kong. Clin Infect Dis 2021; doi:10.1093/cid/ciab919. [IF: 9.079, Journal rank: 3/92 in Infectious Diseases]

3.    Sridhar S (first author), et al. Transmission of rat hepatitis E virus infection to humans in Hong Kong: a clinical and epidemiological analysis. Hepatology 2021; 73(1): 10 – 22.  [IF: 17.425, Journal rank: 6/92 in Gastroenterology & Hepatology)]

4.    Sridhar S (first author), et al. Rat hepatitis E virus as cause of persistent hepatitis after liver transplant. Emerg Infect Dis 2018; 24(12): 2241-50. [IF: 6.883, Journal rank: 7/92 in Infectious Diseases]

5.    Sridhar S (first author), Cheng VCC, Wong SC, et al. Donor-derived genotype 4 hepatitis E virus infection, Hong Kong, China, 2018. Emerg Infect Dis 2019; 25(3): 425 - 433. [IF: 6.883, Journal rank: 7/92 in Infectious Diseases]

6.    Sridhar S (first author), et al. Clinical characteristics and molecular epidemiology of hepatitis E in Shenzhen, China: a shift toward foodborne transmission of hepatitis E virus infection. Emerg Microbes Infect 2017; 6. [IF: 7.163, Journal rank: 6/92 in Infectious Diseases]

7.    Cheng VCC, Sridhar S (Co-first author), et al. Japanese Encephalitis virus transmitted via blood transfusion, Hong Kong, China. Emerg Infect Dis 2018; 24(1). [IF: 6.883, Journal rank: 7/92 in Infectious Diseases]

8.    Sridhar S (first author), et al. Genotype 4 hepatitis E virus is a cause of chronic hepatitis in renal transplant recipients in Hong Kong. J Viral Hepat 2018; 25(2): 209-213. [IF: 3.728, Journal rank: 17/36 in Virology]

9.    Sridhar S (first author), et al. Hepatitis E virus genotypes and evolution: emergence of camel hepatitis E variants. Int J Mol Sci 2017; 18. [IF: 5.923, Journal rank: 67/297 in Biochemistry & Molecular Biology]

10.Sridhar S (first author), et al. Epidemiological and clinical characteristics of human hepegivirus 1 infection in patients with hepatitis C. Open Forum Infect Dis 2019; 6(8). [IF: 3.835, Journal rank: 37/92 in Infectious Diseases]

 

Other first, co-first, and corresponding author publications

1.    Sridhar S (first author), Nicholls J. Pathophysiology of infection with SARS-CoV-2—What is known and what remains a mystery. Respirology 2021; 26(7). [IF: 6.424, Journal rank: 12/64 in Respiratory System]

2.    Yip CCY, Leung KH, Ng ACK, Chan KH, To KKW, Chan JFW, Hung IFN, Cheng VCC, Sridhar S (corresponding author). Comparative evaluation of a dual-target real-time RT-PCR assay for COVID-19 diagnosis and assessment of performance in pooled saliva and nasopharyngeal swab samples. Expert Rev Mol Diagn 2021; 21(7): 741 – 747 [IF: 5.225, Journal rank: 17/77 in Pathology]

3.    Chan KH, Sridhar S (co-first author), Zhang RR, Chu H, Fung AYF, Chan G, Chan JFW, To KKW, Hung IFN, Cheng VCC, Yuen KY. Factors affecting stability and infectivity of SARS-CoV-2. J Hosp Infect 2020; 106(2): 226 – 231. [IF: 3.926, Journal rank: 36/92 in Infectious Diseases]

4.    Yip CCY, Sridhar S (co-first author), Leung KH, Ng ACK, Chan KH, Chan JFW, Tsang OTY, Hung IFN, Cheng VCC, Yuen KY, To KKW. Development and evaluation of novel and highly sensitive single-tube nested real-time rt-pcr assays for sars-cov-2 detection. Int J Mol Sci 2020; 21(16): 1 – 11. [IF: 5.923, Journal rank: 67/297 in Biochemistry & Molecular Biology]

5.    Yip CCY, Sridhar S (co-first author), Cheng AKW, Leung KH, Choi GKY, Chen JHK, Poon RWS, Chan KH, Wu AKL, Chan HSY, Chau SKY, Chung TWH, To KKW, Tsang OTY, Hung IFN, Cheng VCC, Yuen KY, Chan JFW. Evaluation of the commercially available LightMix® Modular E-gene kit using clinical and proficiency testing specimens for SARS-CoV-2 detection. J Clin Virol 2020; 129: article number: 104476. [IF: 3.168, Journal rank: 22/36 in Virology]

6.   Chung TWH, Sridhar S (co-first author), Zhang AJ, Chan KH, Li HL, Wong FKC, Ng MY, Tsang RKY, Fan Z, Ho RSL, Luk SY. Olfactory Dysfunction in Coronavirus Disease 2019 Patients: Observational Cohort Study and Systematic Review. Open Forum Infect Dis 2020; 7(6). [IF: 3.835, Journal rank: 37/92 in Infectious Diseases]

7.    Sridhar S (first author), Chew NFS, Situ J, Wu S, Chui ESH, Lam AHY, Cai JP, Cheng VCC, Yuen KY. Risk of hepatitis e among persons who inject drugs in Hong Kong: A qualitative and quantitative serological analysis. Microorganisms 2020; 8(5). Article number 675. [IF: 4.128, Journal rank: 52/137 in Microbiology]

8.   Sridhar S (first author), et al. Emergence of cytomegalovirus mononucleosis syndrome among young adults in Hong Kong linked to falling seroprevalence: Results of a 14-year seroepidemiological study. Open Forum Infect Dis 2018; 5(10). [IF: 3.835, Journal rank: 37/92 in Infectious Diseases]

9.   Sridhar S (first author), Yip CCY, Chan JFW, To KKW, Cheng VCC, Yuen KY. Impact of inter-genotypic recombination and probe cross-reactivity on the performance of the Abbott RealTime HCV Genotype II assay for hepatitis C genotyping. Diagn Microbiol Infect Dis 2018; 91(1): 34 – 37. [IF: 2.803, Journal rank: 61/92 in Infectious Diseases]