Dr. SHUAI, Hui-ping, Vivian

 

MB (Sun Yat-sen University); PhD (The University of Hong Kong)

 

Research Assistant Professor, Department of Microbiology


Email: shuaihp1@hku.hk

 

ORCID : https://orcid.org/0000-0001-8078-4113

 

 

Research Interests:

In vivo comparative study of the differential pathogenicity and host tropism of newly emerging coronaviruses, including SARS-CoV-1, MERS-CoV and SARS-CoV-2;

Investigation of virus-host interplay with multi-omics analysis in vivo;

Evaluation of the efficacy of novel vaccination strategies and small molecule antivirals in infectious animal models

 

Awards:

2021 Future Female Scientist Program (China Association for Science and Technology, China) https://www.cast.org.cn/art/2022/7/25/art_460_193022.html

 

Selected Publications:

1.        Shuai H*, Chan JF*, Hu B*, Chai Y*, Yuen TT*, Yin F*, Huang X, Yoon C, Hu JC, Liu H, Shi J, Liu Y, Zhu T, Zhang J, Hou Y, Wang Y, Lu L, Cai JP, Zhang AJ, Zhou J, Yuan S, Brindley MA, Zhang BZ, Huang JD, To KK, Yuen KY, Chu H. Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron. Nature. 2022 Jan 21.

2.        Shuai H*, Chan JF*, Yuen TT*, Yoon C, Hu JC, Wen L, Hu B, Yang D, Wang Y, Hou Y, Huang X, Chai Y, Chan CC, Poon VK, Lu L, Zhang RQ, Chan WM, Ip JD, Chu AW, Hu YF, Cai JP, Chan KH, Zhou J, Sridhar S, Zhang BZ, Yuan S, Zhang AJ, Huang JD, To KK, Yuen KY, Chu H. Emerging SARS-CoV-2 variants expand species tropism to murines. EBioMedicine. 2021 Oct 21;73:103643.

3.        Shuai H*, Chu H*, Hou Y*, Yang D, Wang Y, Hu B, Huang X, Zhang X, Chai Y, Cai JP, Chan JF, Yuen KY. Differential immune activation profile of SARS-CoV-2 and SARS-CoV infection in human lung and intestinal cells: implications for treatment with IFN-β and IFN inducer. Journal of Infection. 2020 Oct;81(4):e1-e10.

4.        Quan BX*, Shuai H* (co-first author), Xia AJ*, Hou Y*, Zeng R*, Liu XL*, Lin GF*, Qiao JX, Li WP, Wang FL, Wang K, Zhou RJ, Yuen TT, Chen MX, Yoon C, Wu M, Zhang SY, Huang C, Wang YF, Yang W, Tian C, Li WM, Wei YQ, Yuen KY, Chan JF#, Lei J#, Chu H#, Yang S#. An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron. Nature Microbiology. 2022 May;7(5):716-725. (*co-first author)

5.        Chu H*, Shuai H*(co-first author), Hou Y, Zhang X, Wen L, Huang X, Hu B, Yang D, Wang Y, Yoon C, Wong BH, Li C, Zhao X, Poon VK, Cai JP, Wong KK, Yeung ML, Zhou J, Au-Yeung RK, Yuan S, Jin DY, Kok KH, Perlman S, Chan JF, Yuen KY. Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity. Science Advances. 2021 Jun 16;7(25):eabf8577.

6.        Zhang BZ, Shuai H* *(co-first author), Gong HR, Hu JC, Yan B, Yuen TT, Hu YF, Yoon C, Wang XL, Hou Y, Lin X, Huang X, Li R, Au-Yeung YM, Li W, Hu B, Chai Y, Yue M, Cai JP, Ling GS, Hung IF, Yuen KY, Chan JF, Huang JD, Chu H. Differential immune activation profile of SARS-CoV-2 and SARS-CoV infection in human lung and intestinal cells: implications for treatment with IFN-β and IFN inducer. JCI Insight. 2022 Apr 21:e157393.

7.        Chu H*, Chan JF*, Yuen TT*, Shuai H*(co-first author), Yuan S, Wang Y, Hu B, Yip CC, Tsang JO, Huang X, Chai Y, Yang D, Hou Y, Chik KK, Zhang X, Fung AY, Tsoi HW, Cai JP, Chan WM, Ip JD, Chu AW, Zhou J, Lung DC, Kok KH, To KK, Tsang OT, Chan KH, Yuen KY. Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study. Lancet Microbe. 2020 May;1(1):e14-e23.

8.        Zhang BZ*, Chu H*#, Han S*, Shuai H*(co-first author), Deng J, Hu YF, Gong HR, Lee AC, Zou Z, Yau T, Wu W, Hung IF, Chan JF, Yuen KY, Huang JD. Cell Research. 2020 Oct;30(10):928-931.

9.        Chu H, Hou Y, Yang D, Wen L, Shuai H, Yoon C, Shi J, Chai Y, Yuen TT, Hu B, Li C, Zhao X, Wang Y, Huang X, Lee KS, Luo C, Cai JP, Poon VK, Chan CC, Zhang J, Yuan S, Sit KY, Foo DC, Au WK, Wong KK, Zhou J, Kok KH, Jin DY, Chan JF, Yuen KY. Coronaviruses exploit a host cysteine-aspartic protease for replication. Nature. 2022 Aug. (In press) 

10.    Chu H, Hu B, Huang X, Chai Y, Zhou D, Wang Y, Shuai H, Yang D, Hou Y, Zhang X, Yuen TT, Cai JP, Zhang AJ, Zhou J, Yuan S, To KK, Chan IH, Sit KY, Foo DC, Wong IY, Ng AT, Cheung TT, Law S, Au WK, Brindley MA, Chen Z, Kok KH, Chan JF, Yuen KY. Host and viral determinants for efficient SARS-CoV-2 infection of the human lung. Nature Communications. 2021 Jan 8;12(1):134.