Chen Honglin (陳鴻霖)

 

PhD

 

Professor, Department of Microbiology


Email: hlchen@hku.hk

 

ORCID : https://orcid.org/0000-0001-5108-8338

 

 

Research Interests:

Molecular mechanism for host restriction of virus replication and cross species transmission of animal RNA viruses.
Regulation of Epstein-Barr virus gene expression and aberrant cellular signaling in EBV associated cancers

 

Publications

1. Lin W, Yip YL, Jia L, Deng W, Zheng H, Dai W, Ko JMY, Lo KW, Chung GTY, Yip KY, Lee SD, Kwan JS, Zhang J, Liu T, Chan JY, Kwong DL, Lee VH, Nicholls JM, Busson P, Liu X, Chiang AKS, Hui KF, Kwok H, Cheung ST, Cheung YC, Chan CK, Li B, Cheung AL, Hau PM, Zhou Y, Tsang CM, Middeldorp J, Chen H, Lung ML, Tsao SW. Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma. Nat Commun. 2018 Nov 7;9(1):4663. doi: 10.1038/s41467-018-06889-5.
 

2. Zhou J, Li C, Sachs N, Chiu MC, Wong BH, Chu H, Poon VK, Wang D, Zhao X, Wen L, Song W, Yuan S, Wong KK, Chan JF, To KK, Chen H, Clevers H, Yuen KY. Differentiated human airway organoids to assess infectivity of emerging influenza virus. Proc Natl Acad Sci U S A. 2018 Jun 11. pii: 201806308. doi: 10.1073/pnas.1806308115. [Epub ahead of print]
 

3. Verhoeven RJA, Tong S, Zong J, Chen Y, Tsao SW, Pan J, Chen H. NF-κB Signaling Regulates Epstein-Barr Virus BamHI-Q-Driven EBNA1 Expression. Cancers (Basel). 2018 Apr 16;10(4). pii: E119. doi: 10.3390/cancers10040119.
 

4. Wen L, Chu H, Wong BH, Wang D, Li C, Zhao X, Chiu MC, Yuan S, Fan Y, Chen H, Zhou J, Yuen KY. Large-scale sequence analysis reveals novel human-adaptive markers in PB2 egment of seasonal influenza A viruses. Emerg Microbes Infect. 2018 Mar 29;7(1):47. doi: 10.1038/ s41426-018-0050-0. PMID:29593225
 

5. Chan CP, Yuen CK, Cheung PH, Fung SY, Lui PY, Chen H, Kok KH, Jin DY. ntiviral activity of double-stranded RNA-binding protein PACT against influenza A virus mediated via suppression of viral RNA polymerase. FASEB J. 2018 Mar 7:fj201701361R. doi: 10.1096/fj.201701361R. [Epub ahead of print]
 

6. Zhu H, Lee ACY, Li C, Mak WWN, Chen YY, Chan KH, Zhang AJX, Fung WF, Zhang RQ, Fung YF, Poon RWS, Lam JY, Tam S, Hung IFN, Chen H, Yuen KY, To KKW. Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017. Emerg Microbes Infect. 2018 Mar 6;7(1):23. doi: 10.1038/s41426-018-0041-1.
 

7. Woo PCY, Lau SKP, Chen Y, Wong EYM, Chan KH, Chen H, Zhang L, Xia N, Yuen KY. Rapid detection of MERS coronavirus-like viruses in bats: pote1ntial for tracking MERS coronavirus transmission and animal origin. Emerg Microbes Infect. 2018 Mar 7;7(1):18. doi: 10.1038/s41426-017-0016-7.
 

8. Li T, Guo X, Ji M, Li F, Wang H, Cheng W, Chen H, Ng M, Ge S, Yuan Y, Xia N. Establishment and validation of a two-step screening scheme for improved performance of serological screening of nasopharyngeal carcinoma. Cancer Med. 2018 Feb 25. doi: 10.1002/cam4.1345. [Epub ahead of print]
 

9. Lau SKP, Zhang L, Luk HKH, Xiong L, Peng X, Li KSM, He X, Zhao PS, Fan RYY, Wong ACP, Ahmed SS, Cai JP, Chan JFW, Sun Y, Jin D, Chen H, Lau TCK, Kok RKH, Li W, Yuen KY, Woo PCY. Receptor usage of a novel bat lineage C betacoronavirus reveals evolution of MERS-related coronavirus spike proteins for human DPP4 binding. J Infect Dis. 2018 Jan 16. doi: 10.1093/infdis/jiy018. [Epub ahead of print]
 

10. Mok BW, Liu H, Chen P, Liu S, Lau SY, Huang X, Liu YC, Wang P, Yuen KY, Chen H. The role of nuclear NS1 protein in highly pathogenic H5N1 influenza viruses. Microbes Infect. 2017 Dec;19(12):587-596. doi: 10.1016/j.micinf. 2017. 08.011. Epub 2017 Sep 10.PMID: 28903072
 

11. Shen C, Chen J, Li R, Zhang M, Wang G, Stegalkina S, Zhang L, Chen J, Cao J, Bi X, Anderson SF, Alefantis T, Zhang M, Cai X, Yang K, Zheng Q, Fang M, Yu H, Luo W, Zheng Z, Yuan Q, Zhang J, Wai-Kuo Shih J, Kleanthous H, Chen H, Chen Y, Xia N. A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses. Sci Transl Med. 2017 Oct 18;9(412). pii: eaam5752. doi: 10.1126/scitranslmed.aam5752.
 

12. Chen J, Yang K, Zhang M, Shen C, Chen J, Wang G, Huang S, Zhang M, Xiong H, Chen H, Chen Y, Xia N. Rapid identification of imported influenza viruses at Xiamen International Airport via an active surveillance program. Clin Microbiol Infect. 2017 Jun 3. pii: S1198-43X(17)30288-4. doi: 10.1016/j.cmi.2017.05.027. [Epub ahead of print] PMID:28587905
 

13. Huang X, Zheng M, Wang P, Mok BW, Liu S, Lau SY, Chen P, Liu YC, Liu H, Chen Y, Song W, Yuen KY, Chen H. An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells. Nat Commun. 2017 Mar 21;8: 14751. doi: 10.1038/ncomms 14751.
 

14. Wang S, Ren H, Jiang W, Chen H, Hu H, Chen Z, Zhou P. Divergent requirement of Fc-FcγR interactions for in vivo protection against influenza viruses by two pan-H5 hemagglutinin antibodies. J Virol. 2017 Mar 22. pii: JVI.02065-16. doi: 10.1128/JVI.02065-16. [Epub ahead of print]
 

15. Jiang W, Wang S, Chen H, Ren H, Huang X, Wang G, Chen Z, Chen L, Chen Z, Zhou P. A bivalent heterologous DNA-virus-like particles prime-boost vaccine elicits broad protection against both groups 1 and 2 influenza A viruses. J Virol. 2017 Feb 8. pii: JVI.02052-16. doi: 10.1128/JVI.02052-16. [Epub ahead of print] PMID:28179535
 

16. Hung IF, To KK, Chan JF, Cheng VC, Liu KS, Tam A, Chan TC, Zhang AJ, Li P, Wong TL, Zhang R, Cheung MK, Leung W, Lau JY, Fok M, Chen H, Chan KH, Yuen KY. Efficacy of clarithromycin-naproxen-oseltamivir combination in the treatment of patients hospitalized for influenza A(H3N2) infection: an open-label, randomized controlled, phase 2b/3 trial. Chest. 2016 Nov 21. pii: S0012-3692(16)62393-0. doi: 10.1016/j.chest.2016.11.012. [Epub ahead of print]
 

17. Chen Y, Chan KH, Hong C, Kang Y, Ge S, Chen H, Wong EY, Joseph S, Patteril NG, Wernery U, Xia N, Lau SK, Woo PC. A highly specific rapid antigen detection assay for on-site diagnosis of MERS. J Infect. 2016 Jul;73(1):82-4. doi: 10.1016/j.jinf.2016.04.014. Epub 2016 May 1.
 

18. To KK, Mok KY, Chan AS, Cheung NN, Wang P, Lui YM, Chan JF, Chen H, Chan KH, Kao RY, Yuen KY. Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans..J Gen Virol. 2016 Jun 2. doi: 10.1099/jgv.0.000512. [Epub ahead of print]
 

19. Ren H, Wang G, Wang S, Chen H, Chen Z, Hu H, Cheng G, Zhou P. Cross-protection of newly emerging HPAI H5 viruses by neutralizing human monoclonal antibodies: A viable alternative to oseltamivir. MAbs. 2016 Aug-Sep;8(6):1156-66. doi: 10.1080/19420862.2016. 1183083. Epub 2016 May 11.
 

20. Verhoeven RJ, Tong S, Zhang G, Zong J, Chen Y, Jin DY, Chen MR, Pan J, Chen H. NF-κB Signaling Regulates Expression of Epstein-Barr Virus BART MicroRNAs and Long noncoding RNAs in Nasopharyngeal Carcinoma. J Virol. 2016 Jun 24;90(14):6475-88. doi: 10.1128/JVI.00613-16. Print 2016 Jul 15.
 

21. Xu L, Bao L, Lau SY, Wu WL, Yuan J, Gu S, Li F, Lv Q, Xu Y, Pushko P, Chen H, Qin C. Vaccine. 2016 Apr 12. pii: S0264-410X(16)30004-4. doi: Hemagglutinin amino acids related to receptor specificity could affect the protection efficacy of H5N1 and H7N9 avian influenza virus vaccines in mice.10.1016/j.Vaccine.2016.03.031. [Epub ahead of print]
 

22. Ou H, Yao H, Yao W, Wu N, Wu X, Han C, Cheng L, Chen K, Chen H*, Li L*. Analysis of the immunogenicity and bioactivities of a split influenza A/H7N9 vaccine mixed with MF59 adjuvant in BALB/c mice. Vaccine. 2016 Mar 21. pii: S0264-410X(16)30010-X. doi: 10.1016/j.vaccine.2016.03.037. [Epub ahead of print]
 

23. Lai KK, Cheung NN, Yang F, Dai J, Liu L, Chen Z, Sze KH, Chen H, Yuen KY, Kao RY. Identification of Novel Fusion Inhibitors of Influenza A Virus by Chemical Genetics. J Virol. 2015 Dec 16. pii: J Virol. 02326-15. [Epub ahead of print]
 

24. Yeung ML, Yao Y, Jia L, Chan JF, Chan KH, Cheung KF, Chen H, Poon VK, Tsang AK, To KK, Yiu MK, Teng JL, Chu H, Zhou J, Zhang Q, Deng W, Lau SK, Lau JY, Woo PC, Chan TM, Yung S, Zheng BJ, Jin DY, Mathieson PW, Qin C, Yuen KY. MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2. Nat Microbiol. 2016 Feb 22;1:16004. doi: 10.1038/nmicrobiol.2016.4.
 

25. Hung IF, Zhang AJ, To KK, Chan JF, Li P, Wong TL, Zhang R, Chan TC, Chan BC, Wai HH, Chan LW, Fong HP, Hui RK, Kong KL, Leung AC, Ngan AH, Tsang LW, Yeung AP, Yiu GC, Yung W, Lau JY, Chen H, Chan KH, Yuen KY. Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial. Lancet Infect Dis. 2016 2016 Feb;16(2):209-18. doi: 10.1016/S1473-3099(15)00354-0. Epub 2015 Nov 9.
 

26. Lee AC, Zhu H, Zhang AJ, Li C, Wang P, Li C, Chen H, Hung IF, To KK, Yuen KY. Suboptimal humoral immune response against influenza A(H7N9) virus is related to its internal genes. Clin Vaccine Immunol. 2015 Oct 7. pii: CVI.00443-15. [Epub ahead of print]
 

27. Chan JF, Yao Y, Yeung ML, Deng W, Bao L, Jia L, Li F, Xiao C, Gao H, Yu P, Cai JP, Chu H, Zhou J, Chen H, Qin C, Yuen KY.Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset. J Infect Dis. 2015 Jul 21. pii: jiv392. [Epub ahead of print]
 

28. Zheng M, Wang P, Song W, Lau SY, Liu S, Huang X, Mok BW, Liu YC, Chen Y, Yuen KY, Chen H*. A14U Substitution in 3' Non-Coding Region of M vRNA Supports Replication of NS1-Deleted Influenza Virus by Modulating Alternative Splicing of M mRNAs, J. Virol 89(20):10273-85. doi: 10.1128/ J. Virol .00919-15. Epub 2015 Jul 29.2015 Jul 29. pii: JVI.00919-15.
 

29. Naguib MM, Kinne J, Chen H, Chan KH, Joseph S, Wong PC, Woo PC, Wernery R, Beer M, Wernery U, Harder TC. Outbreaks of highly pathogenic avian influenza H5N1 clade 2.3.2.1c in hunting falcons and kept wild birds in Dubai implicate intercontinental virus spread.J Gen Virol. 2015 Sep 7. doi: 10.1099/jgv.0.000274.
 

30. Lau SK, Feng Y, Chen H, Luk HK, Yang WH, Li KS, Zhang YZ, Huang Y, Song ZZ, Chow WN, Fan RY, Ahmed SS, Yeung HC, Lam CS, Cai JP, Wong SS, Chan JF, Yuen KY, Zhang HL, Woo PC.SARS coronavirus ORF8 protein is acquired from SARS-related coronavirus from greater horseshoe bats through recombination. J Virol. 2015 Aug 12. pii: JVI.01048-15. [Epub ahead of print]
 

31. Chen H, Guan Y, H5N1 virus resistant to antiviral drug. Hong Kong Med J. 2015 Jun;21 Suppl 4:12-3. No abstract available.
 

32. Chen Y, Chan KH, Kang Y, Chen H, Luk H, Poon R, Chan J, Yuen KY, Xia N, Lau S, and Woo P. A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus. Emerging Microbes & Infections (2015) 4, e26; doi:10.1038/emi.2015.26Published online 22 April 2015
 

33. Yuen KS, Chan CP, Wong NH, Ho CH, Ho TH, Lei T, Deng W, Tsao SW, Chen H, Kok KH, Jin DY. CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells. J Gen Virol. 2014 Dec 12. pii: jgv.0.000012. doi: 10.1099/jgv.0.000012. [Epub ahead of print]
 

34. Song W, Wang P, Mok B W-Y, Lau S-Y Lau, Huang X, Wu W-L, Zheng M, Wen X , Yang S, Chen Y, Li L, Yuen KY, Chen H*. K526R substitution in viral protein PB2 enhances the effects of E627K on influenza replication. 2014, Nat Commun. 2014 Nov 20;5:5509. doi: 10.1038/ncomms6509NCOMMS6509.(11)
 

35. Zhang G, Zong J, Lin S, Verhoeven RJ, Tong S, Chen Y, Ji M, Cheng W, Tsao SW, Lung M, Pan J, Chen H*. Circulating Epstein-Barr virus microRNAs miR-BART7 and miR-BART13 as biomarkers for nasopharyngeal carcinoma diagnosis and treatment. Int J Cancer. 2014 Sep 12. doi: 10.1002/ijc.29206. [Epub ahead of print].(7)
 

36. Xiang Z, Liu Y, Zheng J, Liu M, Lv A, Gao Y, Hu H, Lam KT, Chan GC, Yang Y, Chen H, Tsao GS, Bonneville M, Lau YL, Tu W. Targeted Activation of Human Vγ9Vδ2-T Cells Controls Epstein-Barr Virus-Induced B Cell Lymphoproliferative Disease. Cancer Cell. 2014 Sep 10. pii: S1535-6108(14)00314-6. doi: 10.1016/j.ccr.2014.07.026.
 

37. Wen X, X Huang, BWY Mok, Y Chen, MiZheng, S-Y Lau, P Wang, W Song, D-Y Jin, KY Yuen, H Chen (2014) NF90 exerts antiviral activity through regulation of PKR phosphorylation and stress granules in infected cells. J Immunology, 192 (8). April 15, 2014.
 

38. Yao Y, Bao L, Deng W, Xu L, Li F, Lv Q, Yu P, Chen T, Xu Y, Zhu H, Yuan J, Gu S, Wei Q, Chen H, Yuen KY, Qin C. An animal model of MERS produced by infection of Rhesus Macaques with MERS coronavirus. J Infect Dis. 2013 Nov 11. [Epub ahead of print]
 

39. Chan JF, Chan KH, Kao RY, To KK, Zheng BJ, Li CP, Li PT, Dai J, Mok FK, Chen H, Hayden FG, Yuen KY. Broad-Spectrum Antivirals For The Emerging Middle East Respiratory Syndrome Coronavirus. J Infect. 2013 Oct 3. doi:pii: S0163-4453(13)00298-3. 10.1016/j.jinf.2013.09.029. [Epub ahead of print].
 

40. Lei T, Yuen KS, Tsao SW, Chen H, Kok KH, Jin DY. Perturbation of biogenesis and targeting of Epstein-Barr virus-encoded miR-BART3 microRNA by A-to-I editing. J Gen Virol. 2013 Sep 17. [Epub ahead of print].
 

41. Xu L, Bao L, Yuan J, Li F, Lv Q, Deng W, Xu Y, Yao Y, Yu P, Chen H, Yuen KY, Qin C. Antigenicity and transmissibility of a new clade 2.3.2.1 avian influenza H5N1 virus. J Gen Virol. 2013 Sep 28. [Epub ahead of print].
 

42. To KK, Chan JF, Chen H, Li L, Yuen KY(2013) The emergence of influenza A H7N9 in human beings 16 years after influenza A H5N1: a tale of two cities. Lancet Infect Dis. 2013 Sep;13(9):809-21. doi: 10.1016/S1473-3099(13)70167-1.
 

43. Lau SK, Lau CC, Chan KH, Li CP, Chen H, Jin DY, Chan JF, Woo PC, Yuen KY. Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment. J Gen Virol. 2013 Sep 28. [Epub ahead of print]
 

44. Xu L, Bao L, Deng W, Dong L, Zhu H, Chen T, Lv Q, Li F, Yuan J, Xiang Z, Gao K, Xu Y, Huang L, Li Y, Liu J, Yao Y, Yu P, Li X, Huang W, Zhao X, Lan Y, Guo J, Yong W, Wei Q, Chen H, Zhang L, Qin C. Novel Avian-Origin Human Influenza A(H7N9) Can Be Transmitted Between Ferrets via Respiratory Droplets. J Infect Dis. 2013 Sep 24. [Epub ahead of print]
 

45. Liang Y, Wang Z, Chen Y, Ding W, Jia, H, Chan, J, To K, Chen, H, Yang Y, Liang W, Zheng S, Yao H, Yang S, Cao, H, Dai X, Zhao H, Li J, Bao, Q, Chen P, Hou X, Li L, KY Yuen. Clinical, virological, and histopathological manifestations of fatal human infections by avian influenza A(H7N9) virus Clin Infect Dis. cit541 first published online August 13, 2013 doi:10.1093/cid/cit541
 

46. Yang S, Chen Y, Cui D, Yao H, Lou J, Huo Z, Xie G, Yu F, Zheng S, Yang Y, Zhu Y, Lu X, Liu X, Lau SY, Chan JF, To KK, Yuen KY, Chen H, Li L. Avian origin H7N9 virus infection in H7N9-affected areas of China: a serological study. J Infect Dis. 209(2) 265-9; 2013 Aug 9. [Epub ahead of print]
 

47. Chan KH, To KK, Chan JF, Li CP, Chen H, Yuen KY. Evaluation of analytical sensitivity of seven point-of-care influenza detection kits and two molecular tests for detection of avian-origin H7N9 and swine-origin H3N2 variant influenza A viruses. J Clin Microbiol. 2013 Jun 19. [Epub ahead of print].
 

48. Lau SK, Li KS, Tsang AK, Lam CS, Ahmed S, Chen H, Chan KH, Woo PC, Yuen KY. Genetic characterization of Betacoronavirus lineage C viruses in bats revealed marked sequence divergence in the spike protein of Pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications on the origin of the novel Middle East Respiratory Syndrome Coronavirus..J Virol. 2013 Aug;.87(15):8638-50. doi: 10.1128/JVI.01055-13. Epub 2013 May 29
 

49. Chen Y, Liang W, Yang S, Wu N, Gao H, Sheng J, Yao H, Wo J, Fang Q, Cui D, Li Y, Yao X, Zhang Y, Wu H, Zheng S, Diao H, Xia S, Zhang Y, Chan KH, Tsoi HW, Teng JL, Song W, Wang P, Lau SY, Zheng M, Chan JF, To KK, Chen H, Li L, Yuen KY. Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome. Lancet. . 2013 Jun 1;381(9881):1916-25. doi: 10.1016/S0140-6736(13)60903-4. Epub 2013 Apr 25 2013 Apr 25.
 

50. Chan KH, Fuk-Woo Chan J, Tse H, Chen H, Choi-Yi Lau C, Cai JP, Ka-Lun Tsang A, Xiao X, Kai-Wang To K, Kar-Pui Lau S, Chiu-Yat Woo P, Zheng BJ, Wang M, Yuen KY (2013).Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests. J Infect. 2013 Apr 10. doi:pii: S0163-4453(13)00071-6. 10.1016/j.jinf.2013.03.015. [Epub ahead of print]
 

51. Chan JF, Chan KH, Choi GK, To KK, Tse H, Cai JP, Yeung ML, Cheng VC, Chen H, Che XY, Lau SK, Woo PC, Yuen KY. cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications for disease pathogenesis and clinical manifestation.J Infect Dis. 2013 Jun 1;207(11):1743-52. doi: 10.1093/infdis/jit123. Epub 2013 Mar 26.
 

52. Lei T, Yuen KS, Xu R, Tsao SW, Chen H, Li M, Kok KH, Jin DY (2013). Targeting of DICE1 tumor suppressor by Epstein-Barr virus-encoded miR-BART3* microRNA in nasopharyngeal carcinoma. Int. J. Cancer. Dec 27, 2012 doi: 10.1002/ijc.28007. [Epub ahead of print]
 

53. Man Tsang C, Yip YL, Lo KW, Deng W, To KF, Man Hau P, Lau VM, Takada K, Lui VW, Lung ML, Chen H, Zeng M, Middeldorp JM, Cheung AL, Tsao SW (2012). Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells. Proc Natl Acad Sci U S A. 2012 Nov 16. [Epub ahead of print]
 

54. Chan JF, Li KS, To KK, Cheng VC, Chen H, Yuen KY (2012). Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic? J Infect. 2012 Dec;65(6):477-89. doi: 10.1016/j.jinf.2012.10.002. Epub 2012 Oct 13.
 

55. Mok BW, Song W, Wang P, Tai H, Chen Y, Zheng M, Wen X, Lau SY, Wu WL, Matsumoto K, Yuen KY, Chen H. TheNS1 protein of influenza A virus interacts with cellular processing bodies (P-bodies) and stress granules through RNA-associated protein 55 (RAP55) during virus infection. J Virol. 86(23):12695-707; 2012 Sep 12. [Epub ahead of print]
 

56. Zhou F, Wang G, Buchy P, Cai Z, Chen H, Cheng G, Wang XF, Deubel V, Zhou P (2012). A triclade DNA vaccine designed on the basis of a comprehensive serologic study elicits neutralizing antibody responses against all clades and subclades of highly pathogenic avian influenza H5N1 viruses. J. Virol. 86(12):6970-8. Epub 2012 Apr 11.
 

57. Huang K, Zhu H, Fan X, Wang J, Cheung CL, Duan L, Hong W, Liu Y, Li L, Smith DK, Chen H, Webster RG, Webby RJ, Peiris M, Guan Y (2012). .Establishment and lineage replacement of H6 influenza viruses in domestic ducks in southern China. J Virol. 86(11):6075-83. Epub 2012 Mar 21.
 

58. Tsao SW, CM. Tsang, PS. Pang, G. Zhang, H. Chen, KW. Lo (2012). The biology of EBV infection in human epithelial cells. Seminar in Cancer Biology, 22 (2012) 137– 143.
 

59. Wu WL, SY Lau, Y Chen, G. Wang, B. Mok, X. Wen, P. Wang, W. Song, T. Lin, KH. Chan, KY Yuen and H. Chen*(2012). 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: implications for the prevalence of oseltamivir resistant variant viruses. Antiviral Research. 93(1):144-53. 2011 Nov 25. [Epub ahead of print].
 

60. Lai AC, WU WL, Lau SY, Guan Y, Chen H (2011). Two-dimension antigenic dendrogram and phylogenetic tree of avian influenza virus H5N1. FEMS Immunol Med Microbiol. 64(2):205-11. 2011 Oct 31. [Epub ahead of print].
 

61. Tse H , To KK, Wen X, Chen H, Chan KH, Tsoi HW, Li IW, Yuen KY (2011). Clinical and virological factors associated with viremia in pandemic influenza A/H1N1/2009 virus infection. PLoS One. 2011;6(9):e22534. Epub 2011 Sep 27
 

62. Zhang AJ, To KK, Tse H, Chan KH, Guo KY, Li C, Hung IF, Chan JF, Chen H, Tam S, Yuen KY (2011) High incidence of severe influenza among individuals aged over 50 years.. Clin Vaccine Immunol. 2011 Sep 7. [Epub ahead of print].
 

63. Zhu H, Zhou B, Fan X, Lam TT, Wang J, Chen A, Chen X, Chen H, Webster RG, Webby R, Peiris JS, Smith DK, Guan Y. Novel reassortment of Eurasian Avian-like and pandemic/2009 influenza viruses in swine: infectious potential to humans. .J Virol. 2011 Aug 17. [Epub ahead of print]. (3)
 

64. Zhu H, Wang J, Zheng Z, Chen R, Zheng R, Li L, Duan L, Zhang T, Yip EC, Yan Z, Chen H, Peiris JS, Guan Y (2011). Pathogenicity and transmissibility of the pandemic H1N1 2009-related influenza viruses in mice, ferrets, and pigs. Influenza Other Respiratory Viruses. 2011 May;5 Suppl 1:82-4. No abstract available.
 

65. Chu YC, Cheung CL, Hung Leung CY, Man Poon LL, Chen H, Peiris JS, Guan Y (2011). Continuing evolution of H9N2 influenza viruses endemic in poultry in southern China. Influenza Other Respiratory Viruses. 2011 May;5 Suppl 1:68-71. No abstract available.
 

66. Duan L, Zhu H, Wang J, Huang K, Cheung CL, Peiris JS, Chen H, Guan Y (2011). Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China. Influenza Other Respiratory Viruses. 2011 May;5 Suppl 1:65-8. No abstract available.
 

67. Chen Y, Q Zheng, F Zeng, SY Lau, WL Wu, S Huang, J Zhang, H Chen* and N Xia (2011). Serological survey of antibodies to influenza A viruses on a group of people without a history of influenza vaccination. Clinical Microbiology and Infection. Sep;17(9):1347-9. doi: 10.1111/j.1469-0691.2011.03538.x. Epub 2011 Jul 13In Press
 

68. Tse H, R. Kao, WL. Wu, WW. Lim, H. Chen, MY. Yeung, P. Woo, HK Sze, KY Yuen (2011). Structural basis and sequence co-evolution analysis of the hemagglutinini protein of the pandemic influenza A/H1N1 (2009) virus. Experimental Biology and Medicine, 236(8):915-25. Epub 2011 Jul 4.
 

69. Vijaykrishna D, GJ. Smith, OG. Pybus, H. Zhu H, S. Bhatt S, LL. Poon, S. Riley, L. Bahl, SK Ma, CL. Cheung, RA Perera, H. Chen, KF. Shortridge, RJ Webby, RG. Webster, Y. Guan Y, JS. Peiris(2011). Long-term evolution and transmission dynamics of swine influenza A virus. Nature, 473(7348):519-22. (13)
 

70. Zheng Q, L. Xia, WL. Wu, Z. Zheng, Y. Hou, J. Wu, Y. Liu, H, Yu, Y. Chen, S-Y Lau, H. Chen*, W. Luo, N. Xia (2011). Properties and therapeutic efficacy of broadly reactive chimeric and humanized H5-specific monoclonal antibodies against H5N1 influenza viruses. Antimicrobial Agents and Chemotherapy. 55(4):1349-57 Epub 2011 Jan 18.
 

71. Chan KH, KK To, IF Hung, J Zhang, JF Chan, VC Cheng, H Tse, XY Che, H Chen, Yuen KY (2011) Differences in the antibody responses between individuals with natural infection of and those vaccinated against pandemic H1N1 2009 influenza. Clinical Vaccine Immunology. 18(5):867-73 2011 Mar 16. [Epub ahead of print]. (2)
 

72. Cheng VC, Chan JF, Wen X, Wu WL, Que TL, Chen H, Chan KH, Yuen KY (2011). Infection of immunocompromised human by H9N2 influenza A virus. J Infect. 2011 Feb 25. [Epub ahead of print].
 

73. Chan KC, Ko JM, Lung HL, Sedlacek R, Zhang ZF, Luo DZ, Feng ZB, Chen S, Chen H, Chan KW, Tsao SW, Chua DT, Zabarovsky ER, Stanbridge EJ, Lung ML (2011). Catalytic activity of matrix metalloproteinase-19 is essential for tumor suppressor and anti-angiogenic activities in nasopharyngeal carcinoma. Int J Cancer. 2010 Dec 16. [Epub ahead of print]. (2)
 

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115. Ducatez, M.F, H. Chen, Y. Guan and C. P. Muller (2008). Molecular Epidemiology of Chicken Anemia Virus (CAV) in Southeastern Chinese Live Birds Markets. Avian Diseases 52:68–73. (4)
 

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129. Webster RG, DJ. Hulse-Post, KM Sturm-Ramirz, Y. Guan, M. Peiris, G. Smith, and H. Chen (2007) Changing epidemiology and ecology of highly pathogenic avian H5N1 influenza viruses. Avian Dis. 51(1 Suppl):269-72. Review.
 

130. Vijaykrishna D, GJ. Smith, JX Zhang, JX. Peiris, H. Chen, Y Guan (2007) Evolutionary insights into the ecology of coronaviruses. J. Virol. 81(8):4012-20. (Epub 2007 Jan 31). (54)
 

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134. Boltz DA, B. Douangngeun, S. Sinthasak, P. Phommachanh, S. Rolston, H. Chen, Y. Guan, JS Peiris, JG Smith and RG Webster (2006). H5N1 influenza viruses in Lao People’s Democratic Republic. Emerg Infect Dis. 12 (10):1593-5. (12)
 

135. Chu D. K. W, L.L. Poon, K. H. Chan, H. Chen, Y. Guan, K. Y. Yuen and J. S. Peiris (2006) Coronaviruses in bent-winged bats (Miniopterus spp.) J. Gen. Virol 87:2461-2466 doi: 10.1099/vir.0.82203-0. (25)
 

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