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PhD
Professor, Department of Microbiology
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Research Interests:
Molecular mechanism for host restriction of
virus replication and cross species transmission of animal RNA viruses.
Publications
1. Lin W, Yip YL, Jia L, Deng W,
Zheng H, Dai W, Ko JMY, Lo KW, Chung GTY, Yip KY, Lee SD, Kwan JS, Zhang J, Liu
T, Chan JY, Kwong DL, Lee VH, Nicholls JM, Busson P, Liu X, Chiang AKS, Hui KF,
Kwok H, Cheung ST, Cheung YC, Chan CK, Li B, Cheung AL, Hau PM, Zhou Y, Tsang
CM, Middeldorp J,
Chen H, Lung ML, Tsao SW. Establishment and characterization of new tumor
xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma. Nat
Commun. 2018 Nov 7;9(1):4663. doi: 10.1038/s41467-018-06889-5.
2. Zhou J, Li C, Sachs N, Chiu MC,
Wong BH, Chu H, Poon VK, Wang D, Zhao X, Wen L, Song W, Yuan S, Wong KK, Chan
JF, To KK, Chen H, Clevers H, Yuen KY. Differentiated human airway
organoids to assess infectivity of emerging influenza virus. Proc Natl Acad Sci
U S A. 2018 Jun 11. pii: 201806308. doi: 10.1073/pnas.1806308115. [Epub ahead of
print]
3. Verhoeven RJA, Tong S, Zong J,
Chen Y, Tsao SW, Pan J, Chen H. NF-κB Signaling Regulates Epstein-Barr
Virus BamHI-Q-Driven EBNA1 Expression. Cancers (Basel). 2018 Apr 16;10(4). pii:
E119. doi: 10.3390/cancers10040119.
4. Wen L, Chu H, Wong BH, Wang D,
Li C, Zhao X, Chiu MC, Yuan S, Fan Y, Chen H, Zhou J, Yuen KY.
Large-scale sequence analysis reveals novel human-adaptive markers in PB2 egment
of seasonal influenza A viruses. Emerg Microbes Infect. 2018 Mar 29;7(1):47.
doi: 10.1038/ s41426-018-0050-0. PMID:29593225
5. Chan CP, Yuen CK, Cheung PH,
Fung SY, Lui PY, Chen H, Kok KH, Jin DY. ntiviral activity of
double-stranded RNA-binding protein PACT against influenza A virus mediated via
suppression of viral RNA polymerase. FASEB J. 2018 Mar 7:fj201701361R. doi:
10.1096/fj.201701361R. [Epub ahead of print]
6. Zhu H, Lee ACY, Li C, Mak WWN,
Chen YY, Chan KH, Zhang AJX, Fung WF, Zhang RQ, Fung YF, Poon RWS, Lam JY, Tam
S, Hung IFN, Chen H, Yuen KY, To KKW. Low population serum
microneutralization antibody titer against the predominating influenza A(H3N2)
N121K virus during the severe influenza summer peak of Hong Kong in 2017. Emerg
Microbes Infect. 2018 Mar 6;7(1):23. doi: 10.1038/s41426-018-0041-1.
7. Woo PCY, Lau SKP, Chen Y, Wong
EYM, Chan KH, Chen H, Zhang L, Xia N, Yuen KY. Rapid detection of MERS
coronavirus-like viruses in bats: pote1ntial for tracking MERS coronavirus
transmission and animal origin. Emerg Microbes Infect. 2018 Mar 7;7(1):18. doi:
10.1038/s41426-017-0016-7.
8. Li T, Guo X, Ji M, Li F, Wang H,
Cheng W, Chen H, Ng M, Ge S, Yuan Y, Xia N. Establishment and validation
of a two-step screening scheme for improved performance of serological screening
of nasopharyngeal carcinoma. Cancer Med. 2018 Feb 25. doi: 10.1002/cam4.1345.
[Epub ahead of print]
9. Lau SKP, Zhang L, Luk HKH, Xiong
L, Peng X, Li KSM, He X, Zhao PS, Fan RYY, Wong ACP, Ahmed SS, Cai JP, Chan JFW,
Sun Y, Jin D, Chen H, Lau TCK, Kok RKH, Li W, Yuen KY, Woo PCY. Receptor
usage of a novel bat lineage C betacoronavirus reveals evolution of MERS-related
coronavirus spike proteins for human DPP4 binding. J Infect Dis. 2018 Jan 16.
doi: 10.1093/infdis/jiy018. [Epub ahead of print]
10. Mok BW, Liu H, Chen P, Liu S,
Lau SY, Huang X, Liu YC, Wang P, Yuen KY,
Chen H. The role of nuclear NS1 protein in highly pathogenic H5N1
influenza viruses. Microbes Infect. 2017 Dec;19(12):587-596. doi:
10.1016/j.micinf. 2017. 08.011. Epub 2017 Sep 10.PMID: 28903072
11. Shen C, Chen J, Li R, Zhang M,
Wang G, Stegalkina S, Zhang L, Chen J, Cao J, Bi X, Anderson SF, Alefantis T,
Zhang M, Cai X, Yang K, Zheng Q, Fang M, Yu H, Luo W, Zheng Z, Yuan Q, Zhang J,
Wai-Kuo Shih J, Kleanthous H, Chen H, Chen Y, Xia N. A multimechanistic
antibody targeting the receptor binding site potently cross-protects against
influenza B viruses. Sci Transl Med. 2017 Oct 18;9(412). pii: eaam5752. doi:
10.1126/scitranslmed.aam5752.
12. Chen J, Yang K, Zhang M, Shen
C, Chen J, Wang G, Huang S, Zhang M, Xiong H,
Chen H, Chen Y, Xia N. Rapid identification of imported influenza viruses
at Xiamen International Airport via an active surveillance program. Clin
Microbiol Infect. 2017 Jun 3. pii: S1198-43X(17)30288-4. doi:
10.1016/j.cmi.2017.05.027. [Epub ahead of print] PMID:28587905
13. Huang X, Zheng M, Wang P, Mok
BW, Liu S, Lau SY, Chen P, Liu YC, Liu H, Chen Y, Song W, Yuen KY, Chen H.
An NS-segment exonic splicing enhancer regulates influenza A virus replication
in mammalian cells. Nat Commun. 2017 Mar 21;8: 14751. doi: 10.1038/ncomms 14751.
14. Wang S, Ren H, Jiang W, Chen
H, Hu H, Chen Z, Zhou P. Divergent requirement of Fc-FcγR interactions for
in vivo protection against influenza viruses by two pan-H5 hemagglutinin
antibodies. J Virol. 2017 Mar 22. pii: JVI.02065-16. doi: 10.1128/JVI.02065-16.
[Epub ahead of print]
15. Jiang W, Wang S, Chen H,
Ren H, Huang X, Wang G, Chen Z, Chen L, Chen Z, Zhou P. A bivalent heterologous
DNA-virus-like particles prime-boost vaccine elicits broad protection against
both groups 1 and 2 influenza A viruses. J Virol. 2017 Feb 8. pii: JVI.02052-16.
doi: 10.1128/JVI.02052-16. [Epub ahead of print] PMID:28179535
16. Hung IF, To KK, Chan JF, Cheng
VC, Liu KS, Tam A, Chan TC, Zhang AJ, Li P, Wong TL, Zhang R, Cheung MK, Leung
W, Lau JY, Fok M, Chen H, Chan KH, Yuen KY. Efficacy of
clarithromycin-naproxen-oseltamivir combination in the treatment of patients
hospitalized for influenza A(H3N2) infection: an open-label, randomized
controlled, phase 2b/3 trial. Chest. 2016 Nov 21. pii: S0012-3692(16)62393-0.
doi: 10.1016/j.chest.2016.11.012. [Epub ahead of print]
17. Chen Y, Chan KH, Hong C, Kang
Y, Ge S, Chen H, Wong EY, Joseph S, Patteril NG, Wernery U, Xia N, Lau
SK, Woo PC. A highly specific rapid antigen detection assay for on-site
diagnosis of MERS. J Infect. 2016 Jul;73(1):82-4. doi:
10.1016/j.jinf.2016.04.014. Epub 2016 May 1.
18. To KK, Mok KY, Chan AS, Cheung
NN, Wang P, Lui YM, Chan JF, Chen H, Chan KH, Kao RY, Yuen KY.
Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro
antiviral activity against pandemic, seasonal and avian influenza viruses
affecting humans..J Gen Virol. 2016 Jun 2. doi: 10.1099/jgv.0.000512. [Epub
ahead of print]
19. Ren H, Wang G, Wang S, Chen
H, Chen Z, Hu H, Cheng G, Zhou P. Cross-protection of newly emerging HPAI H5
viruses by neutralizing human monoclonal antibodies: A viable alternative to
oseltamivir. MAbs. 2016 Aug-Sep;8(6):1156-66. doi: 10.1080/19420862.2016.
1183083. Epub 2016 May 11.
20. Verhoeven RJ, Tong S, Zhang G,
Zong J, Chen Y, Jin DY, Chen MR, Pan J,
Chen H. NF-κB Signaling Regulates Expression of Epstein-Barr Virus BART
MicroRNAs and Long noncoding RNAs in Nasopharyngeal Carcinoma. J Virol. 2016 Jun
24;90(14):6475-88. doi: 10.1128/JVI.00613-16. Print 2016 Jul 15.
21. Xu L, Bao L, Lau SY, Wu WL,
Yuan J, Gu S, Li F, Lv Q, Xu Y, Pushko P,
Chen H, Qin C. Vaccine. 2016 Apr 12. pii: S0264-410X(16)30004-4. doi:
Hemagglutinin amino acids related to receptor specificity could affect the
protection efficacy of H5N1 and H7N9 avian influenza virus vaccines in
mice.10.1016/j.Vaccine.2016.03.031. [Epub ahead of print]
22. Ou H, Yao H, Yao W, Wu N, Wu X,
Han C, Cheng L, Chen K, Chen H*, Li L*. Analysis of the immunogenicity
and bioactivities of a split influenza A/H7N9 vaccine mixed with MF59 adjuvant
in BALB/c mice. Vaccine. 2016 Mar 21. pii: S0264-410X(16)30010-X. doi:
10.1016/j.vaccine.2016.03.037. [Epub ahead of print]
23. Lai KK, Cheung NN, Yang F, Dai
J, Liu L, Chen Z, Sze KH, Chen H, Yuen KY, Kao RY. Identification of
Novel Fusion Inhibitors of Influenza A Virus by Chemical Genetics. J Virol. 2015
Dec 16. pii: J Virol. 02326-15. [Epub ahead of print]
24. Yeung ML, Yao Y, Jia L, Chan
JF, Chan KH, Cheung KF, Chen H, Poon VK, Tsang AK, To KK, Yiu MK, Teng
JL, Chu H, Zhou J, Zhang Q, Deng W, Lau SK, Lau JY, Woo PC, Chan TM, Yung S,
Zheng BJ, Jin DY, Mathieson PW, Qin C, Yuen KY. MERS coronavirus induces
apoptosis in kidney and lung by upregulating Smad7 and FGF2. Nat Microbiol. 2016
Feb 22;1:16004. doi: 10.1038/nmicrobiol.2016.4.
25. Hung IF, Zhang AJ, To KK, Chan
JF, Li P, Wong TL, Zhang R, Chan TC, Chan BC, Wai HH, Chan LW, Fong HP, Hui RK,
Kong KL, Leung AC, Ngan AH, Tsang LW, Yeung AP, Yiu GC, Yung W, Lau JY, Chen
H, Chan KH, Yuen KY. Topical imiquimod before intradermal trivalent
influenza vaccine for protection against heterologous non-vaccine and
antigenically drifted viruses: a single-centre, double-blind, randomised,
controlled phase 2b/3 trial. Lancet Infect Dis. 2016 2016 Feb;16(2):209-18. doi:
10.1016/S1473-3099(15)00354-0. Epub 2015 Nov 9.
26. Lee AC, Zhu H, Zhang AJ, Li C,
Wang P, Li C, Chen H, Hung IF, To KK, Yuen KY. Suboptimal humoral immune
response against influenza A(H7N9) virus is related to its internal genes. Clin
Vaccine Immunol. 2015 Oct 7. pii: CVI.00443-15. [Epub ahead of print]
27. Chan JF, Yao Y, Yeung ML, Deng
W, Bao L, Jia L, Li F, Xiao C, Gao H, Yu P, Cai JP, Chu H, Zhou J, Chen H,
Qin C, Yuen KY.Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves
Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset. J
Infect Dis. 2015 Jul 21. pii: jiv392. [Epub ahead of print]
28. Zheng M, Wang P, Song W, Lau
SY, Liu S, Huang X, Mok BW, Liu YC, Chen Y, Yuen KY, Chen H*. A14U
Substitution in 3' Non-Coding Region of M vRNA Supports Replication of
NS1-Deleted Influenza Virus by Modulating Alternative Splicing of M mRNAs, J.
Virol 89(20):10273-85. doi: 10.1128/ J. Virol .00919-15. Epub 2015 Jul 29.2015
Jul 29. pii: JVI.00919-15.
29. Naguib MM, Kinne J, Chen H,
Chan KH, Joseph S, Wong PC, Woo PC, Wernery R, Beer M, Wernery U, Harder TC.
Outbreaks of highly pathogenic avian influenza H5N1 clade 2.3.2.1c in hunting
falcons and kept wild birds in Dubai implicate intercontinental virus spread.J
Gen Virol. 2015 Sep 7. doi: 10.1099/jgv.0.000274.
30. Lau SK, Feng Y, Chen H,
Luk HK, Yang WH, Li KS, Zhang YZ, Huang Y, Song ZZ, Chow WN, Fan RY, Ahmed SS,
Yeung HC, Lam CS, Cai JP, Wong SS, Chan JF, Yuen KY, Zhang HL, Woo PC.SARS
coronavirus ORF8 protein is acquired from SARS-related coronavirus from greater
horseshoe bats through recombination. J Virol. 2015 Aug 12. pii: JVI.01048-15.
[Epub ahead of print]
31. Chen H, Guan Y, H5N1
virus resistant to antiviral drug. Hong Kong Med J. 2015 Jun;21 Suppl 4:12-3. No
abstract available.
32. Chen Y, Chan KH, Kang Y,
Chen H, Luk H, Poon R, Chan J, Yuen KY, Xia N, Lau S, and Woo P. A sensitive
and specific antigen detection assay for Middle East respiratory syndrome
coronavirus. Emerging Microbes & Infections (2015) 4, e26;
doi:10.1038/emi.2015.26Published online 22 April 2015
33. Yuen KS, Chan CP, Wong NH, Ho
CH, Ho TH, Lei T, Deng W, Tsao SW, Chen H, Kok KH, Jin DY.
CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells. J Gen
Virol. 2014 Dec 12. pii: jgv.0.000012. doi: 10.1099/jgv.0.000012. [Epub ahead of
print]
34. Song W, Wang P, Mok B W-Y, Lau
S-Y Lau, Huang X, Wu W-L, Zheng M, Wen X , Yang S, Chen Y, Li L, Yuen KY,
Chen H*. K526R substitution in viral protein PB2 enhances the effects of
E627K on influenza replication. 2014, Nat Commun. 2014 Nov 20;5:5509. doi:
10.1038/ncomms6509NCOMMS6509.(11)
35. Zhang G, Zong J, Lin S,
Verhoeven RJ, Tong S, Chen Y, Ji M, Cheng W, Tsao SW, Lung M, Pan J, Chen H*.
Circulating Epstein-Barr virus microRNAs miR-BART7 and miR-BART13 as biomarkers
for nasopharyngeal carcinoma diagnosis and treatment. Int J Cancer. 2014 Sep 12.
doi: 10.1002/ijc.29206. [Epub ahead of print].(7)
36. Xiang Z, Liu Y, Zheng J, Liu M,
Lv A, Gao Y, Hu H, Lam KT, Chan GC, Yang Y,
Chen H, Tsao GS, Bonneville M, Lau YL, Tu W. Targeted Activation of Human
Vγ9Vδ2-T Cells Controls Epstein-Barr Virus-Induced B Cell Lymphoproliferative
Disease. Cancer Cell. 2014 Sep 10. pii: S1535-6108(14)00314-6. doi:
10.1016/j.ccr.2014.07.026.
37. Wen X, X Huang, BWY Mok, Y
Chen, MiZheng, S-Y Lau, P Wang, W Song, D-Y Jin, KY Yuen, H Chen (2014)
NF90 exerts antiviral activity through regulation of PKR phosphorylation and
stress granules in infected cells. J Immunology, 192 (8). April 15, 2014.
38. Yao Y, Bao L, Deng W, Xu L, Li
F, Lv Q, Yu P, Chen T, Xu Y, Zhu H, Yuan J, Gu S, Wei Q, Chen H, Yuen KY,
Qin C. An animal model of MERS produced by infection of Rhesus Macaques with
MERS coronavirus. J Infect Dis. 2013 Nov 11. [Epub ahead of print]
39. Chan JF, Chan KH, Kao RY, To
KK, Zheng BJ, Li CP, Li PT, Dai J, Mok FK,
Chen H, Hayden FG, Yuen KY. Broad-Spectrum Antivirals For The Emerging
Middle East Respiratory Syndrome Coronavirus. J Infect. 2013 Oct 3. doi:pii:
S0163-4453(13)00298-3. 10.1016/j.jinf.2013.09.029. [Epub ahead of print].
40. Lei T, Yuen KS, Tsao SW,
Chen H, Kok KH, Jin DY. Perturbation of biogenesis and targeting of
Epstein-Barr virus-encoded miR-BART3 microRNA by A-to-I editing. J Gen Virol.
2013 Sep 17. [Epub ahead of print].
41. Xu L, Bao L, Yuan J, Li F, Lv
Q, Deng W, Xu Y, Yao Y, Yu P, Chen H, Yuen KY, Qin C. Antigenicity and
transmissibility of a new clade 2.3.2.1 avian influenza H5N1 virus. J Gen Virol.
2013 Sep 28. [Epub ahead of print].
42. To KK, Chan JF, Chen H,
Li L, Yuen KY(2013) The emergence of influenza A H7N9 in human beings 16 years
after influenza A H5N1: a tale of two cities. Lancet Infect Dis. 2013
Sep;13(9):809-21. doi: 10.1016/S1473-3099(13)70167-1.
43. Lau SK, Lau CC, Chan KH, Li CP,
Chen H, Jin DY, Chan JF, Woo PC, Yuen KY. Delayed induction of
proinflammatory cytokines and suppression of innate antiviral response by the
novel Middle East respiratory syndrome coronavirus: implications for
pathogenesis and treatment. J Gen Virol. 2013 Sep 28. [Epub ahead of print]
44. Xu L, Bao L, Deng W, Dong L,
Zhu H, Chen T, Lv Q, Li F, Yuan J, Xiang Z, Gao K, Xu Y, Huang L, Li Y, Liu J,
Yao Y, Yu P, Li X, Huang W, Zhao X, Lan Y, Guo J, Yong W, Wei Q, Chen H,
Zhang L, Qin C. Novel Avian-Origin Human Influenza A(H7N9) Can Be Transmitted
Between Ferrets via Respiratory Droplets. J Infect Dis. 2013 Sep 24. [Epub ahead
of print]
45. Liang Y, Wang Z, Chen Y, Ding
W, Jia, H, Chan, J, To K,
Chen, H, Yang Y, Liang W, Zheng S, Yao H, Yang S, Cao, H, Dai X, Zhao H,
Li J, Bao, Q, Chen P, Hou X, Li L, KY Yuen. Clinical, virological, and
histopathological manifestations of fatal human infections by avian influenza
A(H7N9) virus Clin Infect Dis. cit541 first published online August 13, 2013
doi:10.1093/cid/cit541
46. Yang S, Chen Y, Cui D, Yao H,
Lou J, Huo Z, Xie G, Yu F, Zheng S, Yang Y, Zhu Y, Lu X, Liu X, Lau SY, Chan JF,
To KK, Yuen KY, Chen H, Li L. Avian origin H7N9 virus infection in
H7N9-affected areas of China: a serological study. J Infect Dis. 209(2) 265-9;
2013 Aug 9. [Epub ahead of print]
47. Chan KH, To KK, Chan JF, Li CP,
Chen H, Yuen KY. Evaluation of analytical sensitivity of seven point-of-care
influenza detection kits and two molecular tests for detection of avian-origin
H7N9 and swine-origin H3N2 variant influenza A viruses. J Clin Microbiol. 2013
Jun 19. [Epub ahead of print].
48. Lau SK, Li KS, Tsang AK, Lam
CS, Ahmed S, Chen H, Chan KH, Woo PC, Yuen KY. Genetic characterization
of Betacoronavirus lineage C viruses in bats revealed marked sequence divergence
in the spike protein of Pipistrellus bat coronavirus HKU5 in Japanese
pipistrelle: implications on the origin of the novel Middle East Respiratory
Syndrome Coronavirus..J Virol. 2013 Aug;.87(15):8638-50. doi:
10.1128/JVI.01055-13. Epub 2013 May 29
49. Chen Y, Liang W, Yang S, Wu N,
Gao H, Sheng J, Yao H, Wo J, Fang Q, Cui D, Li Y, Yao X, Zhang Y, Wu H, Zheng S,
Diao H, Xia S, Zhang Y, Chan KH, Tsoi HW, Teng JL, Song W, Wang P, Lau SY, Zheng
M, Chan JF, To KK, Chen H, Li L, Yuen KY. Human infections with the
emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis
and characterisation of viral genome. Lancet. . 2013 Jun 1;381(9881):1916-25.
doi: 10.1016/S0140-6736(13)60903-4. Epub 2013 Apr 25 2013 Apr 25.
50. Chan KH, Fuk-Woo Chan J, Tse H,
Chen H, Choi-Yi Lau C, Cai JP, Ka-Lun Tsang A, Xiao X, Kai-Wang To K,
Kar-Pui Lau S, Chiu-Yat Woo P, Zheng BJ, Wang M, Yuen KY (2013).Cross-reactive
antibodies in convalescent SARS patients' sera against the emerging novel human
coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody
tests. J Infect. 2013 Apr 10. doi:pii: S0163-4453(13)00071-6.
10.1016/j.jinf.2013.03.015. [Epub ahead of print]
51. Chan JF, Chan KH, Choi GK, To
KK, Tse H, Cai JP, Yeung ML, Cheng VC, Chen H, Che XY, Lau SK, Woo PC,
Yuen KY. cell line susceptibility to the emerging novel human betacoronavirus 2c
EMC/2012: implications for disease pathogenesis and clinical manifestation.J
Infect Dis. 2013 Jun 1;207(11):1743-52. doi: 10.1093/infdis/jit123. Epub 2013
Mar 26.
52. Lei T, Yuen KS, Xu R, Tsao SW,
Chen H, Li M, Kok KH, Jin DY (2013). Targeting of DICE1 tumor suppressor by
Epstein-Barr virus-encoded miR-BART3* microRNA in nasopharyngeal carcinoma. Int.
J. Cancer. Dec 27, 2012 doi: 10.1002/ijc.28007. [Epub ahead of print]
53. Man Tsang C, Yip YL, Lo KW,
Deng W, To KF, Man Hau P, Lau VM, Takada K, Lui VW, Lung ML, Chen H, Zeng
M, Middeldorp JM, Cheung AL, Tsao SW (2012). Cyclin D1 overexpression supports
stable EBV infection in nasopharyngeal epithelial cells. Proc Natl Acad Sci U S
A. 2012 Nov 16. [Epub ahead of print]
54. Chan JF, Li KS, To KK, Cheng
VC, Chen H, Yuen KY (2012). Is the discovery of the novel human
betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like
pandemic? J Infect. 2012 Dec;65(6):477-89. doi: 10.1016/j.jinf.2012.10.002. Epub
2012 Oct 13.
55. Mok BW, Song W, Wang P, Tai H,
Chen Y, Zheng M, Wen X, Lau SY, Wu WL, Matsumoto K, Yuen KY, Chen H.
TheNS1 protein of influenza A virus interacts with cellular processing bodies
(P-bodies) and stress granules through RNA-associated protein 55 (RAP55) during
virus infection. J Virol. 86(23):12695-707; 2012 Sep 12. [Epub ahead of print]
56. Zhou F, Wang G, Buchy P, Cai Z,
Chen H, Cheng G, Wang XF, Deubel V, Zhou P (2012). A triclade DNA vaccine
designed on the basis of a comprehensive serologic study elicits neutralizing
antibody responses against all clades and subclades of highly pathogenic avian
influenza H5N1 viruses. J. Virol. 86(12):6970-8. Epub 2012 Apr 11.
57. Huang K, Zhu H, Fan X, Wang J,
Cheung CL, Duan L, Hong W, Liu Y, Li L, Smith DK, Chen H, Webster RG,
Webby RJ, Peiris M, Guan Y (2012). .Establishment and lineage replacement of H6
influenza viruses in domestic ducks in southern China. J Virol. 86(11):6075-83.
Epub 2012 Mar 21.
58. Tsao SW, CM. Tsang, PS. Pang,
G. Zhang, H. Chen, KW. Lo (2012). The biology of EBV infection in human
epithelial cells. Seminar in Cancer Biology, 22 (2012) 137– 143.
59. Wu WL, SY Lau, Y Chen, G. Wang,
B. Mok, X. Wen, P. Wang, W. Song, T. Lin, KH. Chan, KY Yuen and H. Chen*(2012).
2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody
inhibition: implications for the prevalence of oseltamivir resistant variant
viruses. Antiviral Research. 93(1):144-53. 2011 Nov 25. [Epub ahead of print].
60. Lai AC, WU WL, Lau SY, Guan Y,
Chen H (2011). Two-dimension antigenic dendrogram and phylogenetic tree of
avian influenza virus H5N1. FEMS Immunol Med Microbiol. 64(2):205-11. 2011 Oct
31. [Epub ahead of print].
61. Tse H , To KK, Wen X, Chen H,
Chan KH, Tsoi HW, Li IW, Yuen KY (2011). Clinical and virological factors
associated with viremia in pandemic influenza A/H1N1/2009 virus infection. PLoS
One. 2011;6(9):e22534. Epub 2011 Sep 27
62. Zhang AJ, To KK, Tse H, Chan
KH, Guo KY, Li C, Hung IF, Chan JF, Chen H, Tam S, Yuen KY (2011) High
incidence of severe influenza among individuals aged over 50 years.. Clin
Vaccine Immunol. 2011 Sep 7. [Epub ahead of print].
63. Zhu H, Zhou B, Fan X, Lam TT,
Wang J, Chen A, Chen X, Chen H, Webster RG, Webby R, Peiris JS, Smith DK,
Guan Y. Novel reassortment of Eurasian Avian-like and pandemic/2009 influenza
viruses in swine: infectious potential to humans. .J Virol. 2011 Aug 17. [Epub
ahead of print]. (3)
64. Zhu H, Wang J, Zheng Z, Chen R,
Zheng R, Li L, Duan L, Zhang T, Yip EC, Yan Z, Chen H, Peiris JS, Guan Y
(2011). Pathogenicity and transmissibility of the pandemic H1N1 2009-related
influenza viruses in mice, ferrets, and pigs. Influenza Other Respiratory
Viruses. 2011 May;5 Suppl 1:82-4. No abstract available.
65. Chu YC, Cheung CL, Hung Leung
CY, Man Poon LL, Chen H, Peiris JS, Guan Y (2011). Continuing evolution
of H9N2 influenza viruses endemic in poultry in southern China. Influenza Other
Respiratory Viruses. 2011 May;5 Suppl 1:68-71. No abstract available.
66. Duan L, Zhu H, Wang J, Huang K,
Cheung CL, Peiris JS, Chen H, Guan Y (2011). Influenza virus surveillance
in migratory ducks and sentinel ducks at Poyang Lake, China. Influenza Other
Respiratory Viruses. 2011 May;5 Suppl 1:65-8. No abstract available.
67. Chen Y, Q Zheng, F Zeng, SY
Lau, WL Wu, S Huang, J Zhang, H Chen* and N Xia (2011). Serological
survey of antibodies to influenza A viruses on a group of people without a
history of influenza vaccination. Clinical Microbiology and Infection.
Sep;17(9):1347-9. doi: 10.1111/j.1469-0691.2011.03538.x. Epub 2011 Jul 13In
Press
68. Tse H, R. Kao, WL. Wu, WW. Lim,
H. Chen, MY. Yeung, P. Woo, HK Sze, KY Yuen (2011). Structural basis and
sequence co-evolution analysis of the hemagglutinini protein of the pandemic
influenza A/H1N1 (2009) virus. Experimental Biology and Medicine, 236(8):915-25.
Epub 2011 Jul 4.
69. Vijaykrishna D, GJ. Smith, OG.
Pybus, H. Zhu H, S. Bhatt S, LL. Poon, S. Riley, L. Bahl, SK Ma, CL. Cheung, RA
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