Major Research Areas:
| 1. Novel and emerging infectious diseases, and microbial genomics | |
| Discovery and genomic characterisation of novel and emerging pathogens and pathogenic forms, including coronaviruses, influenza virus and other novel viruses and bacteria, through a range of molecular techniques, immunological techniques, animal models, and bioinformatics tools, to win new insights in microbial genomics, and potential diagnostic, therapeutic and vaccine targets. | |
| Professor K.Y. Yuen Tel: (852) 2255 2402 Fax: (852) 2855 1241 Email: kyyuen@hku.hk Dr J.F.W. Chan Tel: (852) 2255 2402 Fax: (852) 2855 1241 Email: jfwchan@hku.hk |
Dr P.M.L. Yeung Tel: (852) 2255 2584 Fax: (852) 2855 1241 Email: pmlyeung@hku.hk Dr P.M.L. Yeung Tel: (852) 2255 2584 Fax: (852) 2855 1241 Email: pmlyeung@hku.hk
|
| 2. Novel and emerging antibiotic resistance | |
| Antibiotic resistance in Streptococcus pneumoniae, enterococci, Staphylococcus aureus, Gram negative, non-fermentors, and enterobacteriaceae, including epidemiology and genomics of resistant bacteria, resistant gene ecology, mechanisms of resistance, clinical relevance, novel methods for diagnosis of difficult-to-detect resistance and evaluation of new antibiotics; novel or emerging beta-lactamases in Gram negative bacteria. | |
| Dr P.L. Ho Tel: (852) 2255 2584 Fax: (852) 2855 1241 Email: plho@hku.hk
|
|
| 3. Respiratory Pathogens Including Influenza Viruses | |
| Research areas focus on application of cutting edge technologies in cellular and molecular biology and reverse genetics to study virus host interaction, in particular on host restriction of influenza virus replication, molecular basis for cross species transmission of influenza A viruses, and aberrant cellular signaling associated with viral pathogenesis of severe influenza and EBV associated tumors | |
|
Prof. H.L. Chen Tel: (852) 3917 9941 Fax: (852) 2855 1241 Email: hlchen@hku.hk |
Dr
K.K.W. To Tel: (852) 2255 2402 Fax: (852) 2855 1241 Email: kelvinto@hku.hk
|
| 4. Microbial pathogenesis | |
| Molecular epidemiology and pathogenesis of enteric pathogens, including Vibrio cholerae and E. coli O157:H7, in relation to public health and environmental hazards; drug resistance mechanism of Mycobacterium tuberculosis and Human Immunodeficiency Virus Type 1 (HIV-1). | |
|
|
|
| 5. Molecular studies of emerging pathogens | |
| Application of chemical genetics and conventional genetic approaches (including cloning, site-directed deletions) to dissect microbial pathogenesis and identify microbial targets of important diagnostic and therapeutic value. Determination of the structures and functions of identified microbial targets using bioinformatics, molecular modelling, NMR spectroscopy, x-ray crystallography and other biophysical methods. Development of computational and experimental methods for efficient drug screening and design | |
| Dr R.Y.T. Kao Tel: (852) 3917 9707 Fax: (852) 2855 1241 Email: rytkao@hku.hk |
|