Publications


Selected Publication List

1: Lam JY, Ng YY, Yuen CK, Wong WM, Yuen KY, Kok KH. A nasal omicron vaccine booster elicits potent neutralizing antibody response against emerging SARS-CoV-2 variants. Emerg Microbes Infect. 2022 Dec;11(1):964-967. doi: 10.1080/22221751.2022.2053365. PMID: 35275039; PMCID: PMC8973333.

2: Zhao H, Meng X, Peng Z, Lam H, Zhang C, Zhou X, Chan JF, Kao RYT, To KK, Yuen KY. Fusion-inhibition peptide broadly inhibits influenza virus and SARS-CoV-2, including Delta and Omicron variants. Emerg Microbes Infect. 2022 Dec;11(1):926-937. doi: 10.1080/22221751.2022.2051753. PMID: 35259078; PMCID: PMC8973381.

3: Kok KH, Wong SC, Chan WM, Wen L, Chu AW, Ip JD, Lee LK, Wong IT, Lo HW, Cheng VC, Ho AY, Lam BH, Tse H, Lung D, Ng KNH, Au AK, Siu GK, Yuen KY. Co-circulation of two SARS-CoV-2 variant strains within imported pet hamsters in Hong Kong. Emerg Microbes Infect. 2022 Dec;11(1):689-698. doi: 10.1080/22221751.2022.2040922. PMID: 35135441; PMCID: PMC8890519.

4: Chen LL, Chua GT, Lu L, Chan BP, Wong JS, Chow CC, Yu TC, Leung AS, Lam SY, Wong TW, Tsang HW, Wong IC, Chan KH, Yuen KY, Ip P, Kwan MY, To KK. Omicron variant susceptibility to neutralizing antibodies induced in children by natural SARS-CoV-2 infection or COVID-19 vaccine. Emerg Microbes Infect. 2022 Dec;11(1):543-547. doi: 10.1080/22221751.2022.2035195. PMID: 35084295; PMCID: PMC8843159.

5: Zhang X, Chu H, Chik KK, Wen L, Shuai H, Yang D, Wang Y, Hou Y, Yuen TT, Cai JP, Yuan S, Yin F, Yuen KY, Chan JF. hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs. Emerg Microbes Infect. 2022 Dec;11(1):519-531. doi: 10.1080/22221751.2022.2032372. PMID: 35060842; PMCID: PMC8843244.

6: Chen Y, Li C, Liu F, Ye Z, Song W, Lee ACY, Shuai H, Lu L, To KK, Chan JF, Zhang AJ, Chu H, Yuen KY. Age-associated SARS-CoV-2 breakthrough infection and changes in immune response in a mouse model. Emerg Microbes Infect. 2022 Dec;11(1):368-383. doi: 10.1080/22221751.2022.2026741. PMID: 34989330; PMCID: PMC8794076.

7: Zhao H, Lu L, Peng Z, Chen LL, Meng X, Zhang C, Ip JD, Chan WM, Chu AW, Chan KH, Jin DY, Chen H, Yuen KY, To KK. SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells. Emerg Microbes Infect. 2022 Dec;11(1):277-283. doi: 10.1080/22221751.2021.2023329. PMID: 34951565; PMCID: PMC8774049.

8: Fong CH, Lu L, Chen LL, Yeung ML, Zhang AJ, Zhao H, Yuen KY, To KK. Interferon-gamma inhibits influenza A virus cellular attachment by reducing sialic acid cluster size. iScience. 2022 Mar 6;25(4):104037. doi: 10.1016/j.isci.2022.104037. PMID: 35330686; PMCID: PMC8938289.

9: Chu H, Chan JF, Yuen KY. Animal models in SARS-CoV-2 research. Nat Methods. 2022 Apr 8. doi: 10.1038/s41592-022-01447-w. Epub ahead of print. PMID: 35396468.

10: Yuan S, Gao X, Tang K, Cai JP, Hu M, Luo P, Wen L, Ye ZW, Luo C, Tsang JO, Chan CC, Huang Y, Cao J, Liang R, Qin Z, Qin B, Yin F, Chu H, Jin DY, Sun R, Chan JF, Cui S, Yuen KY. Targeting papain-like protease for broad-spectrum coronavirus inhibition. Protein Cell. 2022 Apr 6:1–14. doi: 10.1007/s13238-022-00909-3. Epub ahead of print. PMID: 35384604; PMCID: PMC8983325.

11: Cheng VC, Ip JD, Chu AW, Tam AR, Chan WM, Abdullah SMU, Chan BP, Wong SC, Kwan MY, Chua GT, Ip P, Chan JM, Lam BH, To WK, Chuang VW, Yuen KY, Hung IF, To KK. Rapid spread of SARS-CoV-2 Omicron subvariant BA.2 in a single-source community outbreak. Clin Infect Dis. 2022 Mar 10:ciac203. doi: 10.1093/cid/ciac203. Epub ahead of print. PMID: 35271728.

12: Chan MMH, Leung KY, Zhang RRQ, Liu D, Fan Y, Khong MKW, Tam AR, Chen H, Yuen KY, Hung IFN, Chan KH. Diagnostic Value of a SARS-CoV-2 Rapid Test Kit for Detection of Neutralizing Antibodies as a Point-of-Care Surveillance Test. Microbiol Spectr. 2022 Mar 7:e0099321. doi: 10.1128/spectrum.00993-21. Epub ahead of print. PMID: 35254121.

13: Li C, Zhang AJX, Yuen KY. Reply to Teoh et al. Clin Infect Dis. 2022 Mar 5:ciac133. doi: 10.1093/cid/ciac133. Epub ahead of print. PMID: 35247262.

14: Chan JF, Siu GK, Yuan S, Ip JD, Cai JP, Chu AW, Chan WM, Abdullah SMU, Luo C, Chan BP, Yuen TT, Chen LL, Chik KK, Liang R, Cao H, Man Poon VK, Chan CC, Leung KH, Tam AR, Tsang OT, Chan JM, To WK, Lam BH, Lee LK, Lo HW, Wong IT, Leung JS, Wong EY, Chu H, Yip CC, Cheng VC, Chan KH, Tse H, Lung DC, Ng KH, Au AK, Hung IF, Yuen KY, To KK. Probable Animal-to-Human Transmission of SARS-CoV-2 Delta Variant AY.127 Causing a Pet Shop-Related COVID-19 Outbreak in Hong Kong. Clin Infect Dis. 2022 Mar 2:ciac171. doi: 10.1093/cid/ciac171. Epub ahead of print. PMID: 35234870; PMCID: PMC8903450.

15: Peng Q, Zhou R, Wang Y, Zhao M, Liu N, Li S, Huang H, Yang D, Au KK, Wang H, Man K, Yuen KY, Chen Z. Waning immune responses against SARS-CoV-2 variants of concern among vaccinees in Hong Kong. EBioMedicine. 2022 Mar;77:103904. doi: 10.1016/j.ebiom.2022.103904. Epub 2022 Mar 3. PMID: 35248996; PMCID: PMC8893246.

16: Shuai H, Chan JF, Hu B, Chai Y, Yuen TT, Yin F, Huang X, Yoon C, Hu JC, Liu H, Shi J, Liu Y, Zhu T, Zhang J, Hou Y, Wang Y, Lu L, Cai JP, Zhang AJ, Zhou J, Yuan S, Brindley MA, Zhang BZ, Huang JD, To KK, Yuen KY, Chu H. Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron. Nature. 2022 Mar;603(7902):693-699. doi: 10.1038/s41586-022-04442-5. Epub 2022 Jan 21. PMID: 35062016.

17: Li X, Chen H, Lu L, Chen LL, Chan BP, Wong SC, Cheng VC, Yuen KY, Chan KH, To KK. High compliance to infection control measures prevented guest-to-staff transmission in COVID-19 quarantine hotels. J Infect. 2022 Mar;84(3):418-467. doi: 10.1016/j.jinf.2021.10.016. Epub 2021 Oct 27. PMID: 34715237; PMCID: PMC8548840.

18: Li C, Ye Z, Zhang AJ, Chan JF, Song W, Liu F, Chen Y, Kwan MY, Lee AC, Zhao Y, Wong BH, Yip CC, Cai JP, Lung DC, Sridhar S, Jin D, Chu H, To KK, Yuen KY. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections by intranasal or testicular inoculation induces testicular damage preventable by vaccination in golden Syrian hamsters. Clin Infect Dis. 2022 Feb 18:ciac142. doi: 10.1093/cid/ciac142. Epub ahead of print. PMID: 35178548; PMCID: PMC8903466.

19: Wang D, Li C, Chiu MC, Yu Y, Liu X, Zhao X, Huang J, Cheng Z, Yuan S, Poon V, Cai JP, Chu H, Chan JF, To KK, Yuen KY, Zhou J. SPINK6 inhibits human airway serine proteases and restricts influenza virus activation. EMBO Mol Med. 2022 Jan 11;14(1):e14485. doi: 10.15252/emmm.202114485. Epub 2021 Nov 26. PMID: 34826211.

20: Li X, Chan JM, Lam B, Lung DC, Lung KC, Chow CK, Tam T, Chiu KH, Hung LL, Hung IF, Cheng VC, To KK, Yuen KY. COVID-19 mRNA vaccines delay the onset of breakthrough infections with less radiographic abnormalities. Clin Infect Dis. 2022 Jan 4:ciab1062. doi: 10.1093/cid/ciab1062. Epub ahead of print. PMID: 34984442; PMCID: PMC8755373.

21: Zhou R, To KK, Peng Q, Chan JM, Huang H, Yang D, Lam BH, Chuang VW, Cai JP, Liu N, Au KK, Tsang OT, Yuen KY, Chen Z. Vaccine-breakthrough infection by the SARS-CoV-2 omicron variant elicits broadly cross-reactive immune responses. Clin Transl Med. 2022 Jan;12(1):e720. doi: 10.1002/ctm2.720. PMID: 35083867; PMCID: PMC8792449.

22: Lu L, Mok BW, Chen LL, Chan JM, Tsang OT, Lam BH, Chuang VW, Chu AW, Chan WM, Ip JD, Chan BP, Zhang R, Yip CC, Cheng VC, Chan KH, Jin DY, Hung IF, Yuen KY, Chen H, To KK. Neutralization of SARS-CoV-2 Omicron variant by sera from BNT162b2 or Coronavac vaccine recipients. Clin Infect Dis. 2021 Dec 16:ciab1041. doi: 10.1093/cid/ciab1041. Epub ahead of print. PMID: 34915551; PMCID: PMC8754807.

23: Li C, Chen Y, Zhao Y, Christopher Lung D, Ye Z, Song W, Liu FF, Cai JP, Wong WM, Chik-YanYip C, Fuk-Woo Chan J, Kai-Wang To K, Sridhar S, Fan-Ngai Hung I, Chu H, Kok KH, Jin DY, JinxiaZhang A, Yuen KY. Corrigendum to: Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model. Clin Infect Dis. 2021 Dec 16;73(12):2372-2373. doi: 10.1093/cid/ciab941. Erratum for: Clin Infect Dis. 2021 Aug 18;: PMID: 34849654; PMCID: PMC8690168.

24: Lam AH, Cai JP, Leung KY, Zhang RR, Liu D, Fan Y, Tam AR, Cheng VC, To KK, Yuen KY, Hung IF, Chan KH. In-House Immunofluorescence Assay for Detection of SARS-CoV-2 Antigens in Cells from Nasopharyngeal Swabs as a Diagnostic Method for COVID-19. Diagnostics (Basel). 2021 Dec 13;11(12):2346. doi: 10.3390/diagnostics11122346. PMID: 34943583; PMCID: PMC8700487.

25: Cheng VC, Siu GK, Wong SC, Au AK, Ng CS, Chen H, Li X, Lee LK, Leung JS, Lu KK, Lo HW, Wong EY, Luk S, Lam BH, To WK, Lee RA, Lung DC, Kwan MY, Tse H, Chuang SK, To KK, Yuen KY. Complementation of contact tracing by mass testing for successful containment of beta COVID-19 variant (SARS-CoV-2 VOC B.1.351) epidemic in Hong Kong. Lancet Reg Health West Pac. 2021 Dec;17:100281. doi: 10.1016/j.lanwpc.2021.100281. Epub 2021 Oct 1. PMID: 34611629; PMCID: PMC8483778.

26: Wang X, Lam JY, Chen L, Au SW, To KKW, Yuen KY, Kok KH. Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients. Emerg Microbes Infect. 2021 Dec;10(1):1016-1023. doi: 10.1080/22221751.2021.1931465. PMID: 34003073; PMCID: PMC8186430.

27: Poon RW, Lu L, Fong CH, Ip TC, Chen LL, Zhang RR, Yip CC, Cheng VC, Chan KH, Yuen KY, To KK. Correlation between Commercial Anti-RBD IgG Titer and Neutralization Titer against SARS-CoV-2 Beta Variant. Diagnostics (Basel). 2021 Nov 27;11(12):2216. doi: 10.3390/diagnostics11122216. PMID: 34943453; PMCID: PMC8700542.

28: Li C, Zhang AJX, Yuen KY. Reply to Correa, et al. Clin Infect Dis. 2021 Nov 27:ciab981. doi: 10.1093/cid/ciab981. Epub ahead of print. PMID: 34849653.

29: To KK, Hung IF, Ip JD, Chu AW, Chan WM, Tam AR, Fong CH, Yuan S, Tsoi HW, Ng AC, Lee LL, Wan P, Tso EY, To WK, Tsang DN, Chan KH, Huang JD, Kok KH, Cheng VC, Yuen KY. Coronavirus Disease 2019 (COVID-19) Re-infection by a Phylogenetically Distinct Severe Acute Respiratory Syndrome Coronavirus 2 Strain Confirmed by Whole Genome Sequencing. Clin Infect Dis. 2021 Nov 2;73(9):e2946-e2951. doi: 10.1093/cid/ciaa1275. PMID: 32840608; PMCID: PMC7499500.

30: Sridhar S, Yip CC, Lo KH, Wu S, Situ J, Chew NF, Leung KH, Chan HS, Wong SC, Leung AW, Tse CW, Fung KSC, Tsang OT, Hon KL, Cheng VC, Ng KH, Yuen KY. Hepatitis E virus species C infection in humans, Hong Kong. Clin Infect Dis. 2021 Oct 27:ciab919. doi: 10.1093/cid/ciab919. Epub ahead of print. PMID: 34718428.

31: Yuan S, Yan B, Cao J, Ye ZW, Liang R, Tang K, Luo C, Cai J, Chu H, Chung TW, To KK, Hung IF, Jin DY, Chan JF, Yuen KY. SARS-CoV-2 exploits host DGAT and ADRP for efficient replication. Cell Discov. 2021 Oct 26;7(1):100. doi: 10.1038/s41421-021-00338-2. PMID: 34702802; PMCID: PMC8548329.

32: Yuan SF, Wen L, Chik KK, Du J, Ye ZW, Cao JL, Tang KM, Liang RH, Cai JP, Luo CT, Yin FF, Lu G, Chu H, Liang MF, Jin DY, Yuen KY, Chan JF. In Silico Structure-Based Design of Antiviral Peptides Targeting the Severe Fever with Thrombocytopenia Syndrome Virus Glycoprotein Gn. Viruses. 2021 Oct 11;13(10):2047. doi: 10.3390/v13102047. PMID: 34696477; PMCID: PMC8539749.

33: Cao J, Lu G, Wen L, Luo P, Huang Y, Liang R, Tang K, Qin Z, Chan CC, Chik KK, Du J, Yin F, Ye ZW, Chu H, Jin DY, Yuen KY, Chan JF, Yuan S. Severe fever with thrombocytopenia syndrome virus (SFTSV)-host interactome screen identifies viral nucleoprotein-associated host factors as potential antiviral targets. Comput Struct Biotechnol J. 2021 Oct 1;19:5568-5577. doi: 10.1016/j.csbj.2021.09.034. PMID: 34712400; PMCID: PMC8523828.

34: Mok BW, Liu H, Deng S, Liu J, Zhang AJ, Lau SY, Liu S, Tam RC, Cremin CJ, Ng TT, Leung JS, Lee LK, Wang P, To KK, Chan JF, Chan KH, Yuen KY, Siu GK, Chen H. Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters. Commun Biol. 2021 Sep 20;4(1):1102. doi: 10.1038/s42003-021-02640-x. PMID: 34545191; PMCID: PMC8452646.

35: Chan JF, Poon VK, Chan CC, Chik KK, Tsang JO, Zou Z, Chan CC, Lee AC, Li C, Liang R, Cao J, Tang K, Yuen TT, Hu B, Huang X, Chai Y, Shuai H, Luo C, Cai JP, Chan KH, Sridhar S, Yin F, Kok KH, Chu H, Zhang AJ, Yuan S, Yuen KY. Low Environmental Temperature Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Golden Syrian Hamsters. Clin Infect Dis. 2021 Sep 18:ciab817. doi: 10.1093/cid/ciab817. Epub ahead of print. PMID: 34536277.

36: Cheng VC, Fung KS, Siu GK, Wong SC, Cheng LS, Wong MS, Lee LK, Chan WM, Chau KY, Leung JS, Chu AW, Chan WS, Lu KK, Tam KK, Ip JD, Leung KS, Lung DC, Tse H, To KK, Yuen KY. Nosocomial Outbreak of Coronavirus Disease 2019 by Possible Airborne Transmission Leading to a Superspreading Event. Clin Infect Dis. 2021 Sep 15;73(6):e1356-e1364. doi: 10.1093/cid/ciab313. PMID: 33851214; PMCID: PMC8083289.

37: To KK, Li X, Lung DC, Ip JD, Chan WM, Chu AW, Yip CC, Chen JHK, Poon RW, Tsoi HW, Lai RW, To WK, Ren L, Li M, Cao Y, Xie XS, Jin DY, Yuen KY. False COVID-19 cases due to contamination by inactivated virus vaccine. Clin Infect Dis. 2021 Sep 9:ciab684. doi: 10.1093/cid/ciab684. Epub ahead of print. PMID: 34498683; PMCID: PMC8499976.

38: Lu L, Chu AW, Zhang RR, Chan WM, Ip JD, Tsoi HW, Chen LL, Cai JP, Lung DC, Tam AR, Yau YS, Kwan MY, To WK, Tsang OT, Lee LL, Yi H, Ip TC, Poon RW, Siu GK, Mok BW, Cheng VC, Chan KH, Yuen KY, Hung IF, To KK. The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serum. EBioMedicine. 2021 Sep;71:103544. doi: 10.1016/j.ebiom.2021.103544. Epub 2021 Aug 19. PMID: 34419925; PMCID: PMC8374549.

39: Li C, Chen Y, Zhao Y, Lung DC, Ye Z, Song W, Liu FF, Cai JP, Wong WM, Yip CC, Chan JF, To KK, Sridhar S, Hung IF, Chu H, Kok KH, Jin DY, Zhang AJ, Yuen KY. Intravenous injection of COVID-19 mRNA vaccine can induce acute myopericarditis in mouse model. Clin Infect Dis. 2021 Aug 18:ciab707. doi: 10.1093/cid/ciab707. Epub ahead of print. Erratum in: Clin Infect Dis. 2021 Dec 16;73(12):2372-2373. PMID: 34406358; PMCID: PMC8436386.

40: Lee AC, Zhang AJ, Li C, Chen Y, Liu F, Zhao Y, Chu H, Fong CH, Wang P, Lau SY, To KK, Chen H, Yuen KY. Intradermal vaccination of live attenuated influenza vaccine protects mice against homologous and heterologous influenza challenges. NPJ Vaccines. 2021 Aug 4;6(1):95. doi: 10.1038/s41541-021-00359-8. PMID: 34349128; PMCID: PMC8339132.

41: Li C, Chen YX, Liu FF, Lee AC, Zhao Y, Ye ZH, Cai JP, Chu H, Zhang RQ, Chan KH, Chiu KH, Lung DC, Sridhar S, Hung IF, To KK, Zhang AJ, Chan JF, Yuen KY. Absence of Vaccine-enhanced Disease With Unexpected Positive Protection Against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by Inactivated Vaccine Given Within 3 Days of Virus Challenge in Syrian Hamster Model. Clin Infect Dis. 2021 Aug 2;73(3):e719-e734. doi: 10.1093/cid/ciab083. PMID: 33515458; PMCID: PMC7929057.

42: Chen LL, Lu L, Choi CY, Cai JP, Tsoi HW, Chu AW, Ip JD, Chan WM, Zhang RR, Zhang X, Tam AR, Lau DP, To WK, Que TL, Yip CC, Chan KH, Cheng VC, Yuen KY, Hung IF, To KK. Impact of SARS-CoV-2 variant-associated RBD mutations on the susceptibility to serum antibodies elicited by COVID-19 infection or vaccination. Clin Infect Dis. 2021 Jul 26:ciab656. doi: 10.1093/cid/ciab656. Epub ahead of print. PMID: 34309648.

43: Zhang AJ, Lee AC, Chu H, Chan JF, Fan Z, Li C, Liu F, Chen Y, Yuan S, Poon VK, Chan CC, Cai JP, Wu KL, Sridhar S, Chan YS, Yuen KY. Severe Acute Respiratory Syndrome Coronavirus 2 Infects and Damages the Mature and Immature Olfactory Sensory Neurons of Hamsters. Clin Infect Dis. 2021 Jul 15;73(2):e503-e512. doi: 10.1093/cid/ciaa995. PMID: 32667973; PMCID: PMC7454453.

44: Wong YC, Lau SY, Wang To KK, Mok BWY, Li X, Wang P, Deng S, Woo KF, Du Z, Li C, Zhou J, Chan JFW, Yuen KY, Chen H, Chen Z. Natural Transmission of Bat-like Severe Acute Respiratory Syndrome Coronavirus 2 Without Proline-Arginine-Arginine-Alanine Variants in Coronavirus Disease 2019 Patients. Clin Infect Dis. 2021 Jul 15;73(2):e437-e444. doi: 10.1093/cid/ciaa953. PMID: 32649739; PMCID: PMC7454488.

45: Hung IF, Yap DY, Yip TP, Zhang RR, To KK, Chan KH, Tang SC, Lui SL, Levin Y, Kochba E, Lau JY, Yuen MF, Chan TM, Yuen KY. A Double-blind, Randomized Phase 2 Controlled Trial of Intradermal Hepatitis B Vaccination With a Topical Toll-like Receptor 7 Agonist Imiquimod, in Patients on Dialysis. Clin Infect Dis. 2021 Jul 15;73(2):e304-e311. doi: 10.1093/cid/ciaa804. PMID: 32556176.

46: Lai KK, Cheung NN, Yang F, Dai J, Liu L, Chen Z, Sze KH, Chen H, Yuen KY, Kao RYT. Correction for Lai et al., "Identification of Novel Fusion Inhibitors of Influenza A Virus by Chemical Genetics". J Virol. 2021 Jul 12;95(15):e0066521. doi: 10.1128/JVI.00665-21. Epub 2021 Jul 12. Erratum for: J Virol. 2015 Dec 16;90(5):2690-701. PMID: 34251283; PMCID: PMC8274597.

47: To KK, Chan WM, Ip JD, Chu AW, Tam AR, Liu R, Wu AK, Lung KC, Tsang OT, Lau DP, To WK, Kwan MY, Yau YS, Ng AC, Yip CC, Chan KH, Tse H, Hung IF, Yuen KY. Unique Clusters of Severe Acute Respiratory Syndrome Coronavirus 2 Causing a Large Coronavirus Disease 2019 Outbreak in Hong Kong. Clin Infect Dis. 2021 Jul 1;73(1):137-142. doi: 10.1093/cid/ciaa1119. PMID: 32756996; PMCID: PMC7454385.

48: Chu H, Shuai H, Hou Y, Zhang X, Wen L, Huang X, Hu B, Yang D, Wang Y, Yoon C, Wong BH, Li C, Zhao X, Poon VK, Cai JP, Wong KK, Yeung ML, Zhou J, Au-Yeung RK, Yuan S, Jin DY, Kok KH, Perlman S, Chan JF, Yuen KY. Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity. Sci Adv. 2021 Jun 16;7(25):eabf8577. doi: 10.1126/sciadv.abf8577. PMID: 34134991; PMCID: PMC8208716.

49: Zhang AJ, Lee AC, Chan JF, Liu F, Li C, Chen Y, Chu H, Lau SY, Wang P, Chan CC, Poon VK, Yuan S, To KK, Chen H, Yuen KY. Coinfection by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza A(H1N1)pdm09 Virus Enhances the Severity of Pneumonia in Golden Syrian Hamsters. Clin Infect Dis. 2021 Jun 15;72(12):e978-e992. doi: 10.1093/cid/ciaa1747. PMID: 33216851; PMCID: PMC7717201.

50: Liu S, Mok BW, Deng S, Liu H, Wang P, Song W, Chen P, Huang X, Zheng M, Lau SY, Cremin CJ, Tam CY, Li B, Jiang L, Chen Y, Yuen KY, Chen H. Mammalian cells use the autophagy process to restrict avian influenza virus replication. Cell Rep. 2021 Jun 8;35(10):109213. doi: 10.1016/j.celrep.2021.109213. PMID: 34107256.

51: Sridhar S, Situ J, Cai JP, Yip CC, Wu S, Zhang AJ, Wen L, Chew NF, Chan WM, Poon RW, Chan JF, Tsang DN, Chen H, Xia NS, Yuen KY. Multimodal investigation of rat hepatitis E virus antigenicity: Implications for infection, diagnostics, and vaccine efficacy. J Hepatol. 2021 Jun;74(6):1315-1324. doi: 10.1016/j.jhep.2020.12.028. Epub 2021 Apr 9. PMID: 33845058.

52: To KK, Hung IF, Chan KH, Yuan S, To WK, Tsang DN, Cheng VC, Chen Z, Kok KH, Yuen KY. Serum Antibody Profile of a Patient With Coronavirus Disease 2019 Reinfection. Clin Infect Dis. 2021 May 18;72(10):e659-e662. doi: 10.1093/cid/ciaa1368. PMID: 32966566; PMCID: PMC7543314.

53: Wang P, Lau SY, Deng S, Chen P, Mok BW, Zhang AJ, Lee AC, Chan KH, Tam RC, Xu H, Zhou R, Song W, Liu L, To KK, Chan JF, Chen Z, Yuen KY, Chen H. Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein. Nat Commun. 2021 May 13;12(1):2790. doi: 10.1038/s41467-021-23166-0. PMID: 33986286; PMCID: PMC8119425.

54: Chan WM, Ip JD, Chu AW, Tse H, Tam AR, Li X, Kwan MY, Yau YS, Leung WS, Chik TS, To WK, Ng AC, Yip CC, Poon RW, Chan KH, Wong SC, Choi GK, Lung DC, Cheng VC, Hung IF, Yuen KY, To KK. Phylogenomic analysis of COVID-19 summer and winter outbreaks in Hong Kong: An observational study. Lancet Reg Health West Pac. 2021 May;10:100130. doi: 10.1016/j.lanwpc.2021.100130. Epub 2021 Mar 23. PMID: 33778795; PMCID: PMC7985010.

55: Yuan S, Yin X, Meng X, Chan JF, Ye ZW, Riva L, Pache L, Chan CC, Lai PM, Chan CC, Poon VK, Lee AC, Matsunaga N, Pu Y, Yuen CK, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Lau CY, Sit KY, Au WK, Wang R, Zhang YY, Tang YD, Clausen TM, Pihl J, Oh J, Sze KH, Zhang AJ, Chu H, Kok KH, Wang D, Cai XH, Esko JD, Hung IF, Li RA, Chen H, Sun H, Jin DY, Sun R, Chanda SK, Yuen KY. Clofazimine broadly inhibits coronaviruses including SARS-CoV-2. Nature. 2021 May;593(7859):418-423. doi: 10.1038/s41586-021-03431-4. Epub 2021 Mar 16. PMID: 33727703.

56: Yeung ML, Teng JLL, Jia L, Zhang C, Huang C, Cai JP, Zhou R, Chan KH, Zhao H, Zhu L, Siu KL, Fung SY, Yung S, Chan TM, To KK, Chan JF, Cai Z, Lau SKP, Chen Z, Jin DY, Woo PCY, Yuen KY. Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system. Cell. 2021 Apr 15;184(8):2212-2228.e12. doi: 10.1016/j.cell.2021.02.053. Epub 2021 Mar 2. PMID: 33713620; PMCID: PMC7923941.

57: Zhou D, Chan JF, Zhou B, Zhou R, Li S, Shan S, Liu L, Zhang AJ, Chen SJ, Chan CC, Xu H, Poon VK, Yuan S, Li C, Chik KK, Chan CC, Cao J, Chan CY, Kwan KY, Du Z, Lau TT, Zhang Q, Zhou J, To KK, Zhang L, Ho DD, Yuen KY, Chen Z. Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies. Cell Host Microbe. 2021 Apr 14;29(4):551-563.e5. doi: 10.1016/j.chom.2021.02.019. Epub 2021 Feb 25. PMID: 33657424; PMCID: PMC7904446.

58: Yang F, Pang B, Lai KK, Cheung NN, Dai J, Zhang W, Zhang J, Chan KH, Chen H, Sze KH, Zhang H, Hao Q, Yang D, Yuen KY, Kao RY. Discovery of a Novel Specific Inhibitor Targeting Influenza A Virus Nucleoprotein with Pleiotropic Inhibitory Effects on Various Steps of the Viral Life Cycle. J Virol. 2021 Apr 12;95(9):e01432-20. doi: 10.1128/JVI.01432-20. PMID: 33627391; PMCID: PMC8104107.

59: Wen L, Tang K, Chik KK, Chan CC, Tsang JO, Liang R, Cao J, Huang Y, Luo C, Cai JP, Ye ZW, Yin F, Chu H, Jin DY, Yuen KY, Yuan S, Chan JF. <i>In silico</i> structure-based discovery of a SARS-CoV-2 main protease inhibitor. Int J Biol Sci. 2021 Apr 10;17(6):1555-1564. doi: 10.7150/ijbs.59191. PMID: 33907519; PMCID: PMC8071767.

60: Yuen CK, Wong WM, Mak LF, Wang X, Chu H, Yuen KY, Kok KH. Suppression of SARS-CoV-2 infection in ex-vivo human lung tissues by targeting class III phosphoinositide 3-kinase. J Med Virol. 2021 Apr;93(4):2076-2083. doi: 10.1002/jmv.26583. Epub 2020 Oct 30. PMID: 33026649; PMCID: PMC7675438.

61: Li X, Chan JF, Li KK, Tso EY, Yip CC, Sridhar S, Chung TW, Chiu KH, Hung DL, Wu AK, Chau SK, Liu R, Lung KC, Tam AR, Cheng VC, To KK, Chan KH, Hung IF, Yuen KY. Detection of SARS-CoV-2 in conjunctival secretions from patients without ocular symptoms. Infection. 2021 Apr;49(2):257-265. doi: 10.1007/s15010-020-01524-2. Epub 2020 Sep 17. PMID: 32944840; PMCID: PMC7497856.

62: Zhao H, To KKW, Lam H, Zhou X, Chan JF, Peng Z, Lee ACY, Cai J, Chan WM, Ip JD, Chan CC, Yeung ML, Zhang AJ, Chu AWH, Jiang S, Yuen KY. Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2. Nat Commun. 2021 Mar 9;12(1):1517. doi: 10.1038/s41467-021-21825-w. PMID: 33750821; PMCID: PMC7943568.

63: Zhao X, Li C, Liu X, Chiu MC, Wang D, Wei Y, Chu H, Cai JP, Hau-Yee Chan I, Kak-Yuen Wong K, Fuk-Woo Chan J, Kai-Wang To K, Yuen KY, Zhou J. Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus. Stem Cell Reports. 2021 Mar 9;16(3):493-504. doi: 10.1016/j.stemcr.2021.02.009. Epub 2021 Feb 12. PMID: 33626333; PMCID: PMC7940440.

64: Chu H, Hu B, Huang X, Chai Y, Zhou D, Wang Y, Shuai H, Yang D, Hou Y, Zhang X, Yuen TT, Cai JP, Zhang AJ, Zhou J, Yuan S, To KK, Chan IH, Sit KY, Foo DC, Wong IY, Ng AT, Cheung TT, Law SY, Au WK, Brindley MA, Chen Z, Kok KH, Chan JF, Yuen KY. Host and viral determinants for efficient SARS-CoV-2 infection of the human lung. Nat Commun. 2021 Jan 8;12(1):134. doi: 10.1038/s41467-020-20457-w. PMID: 33420022; PMCID: PMC7794309.

65: Chu H, Chan JF, Wang Y, Yuen TT, Chai Y, Shuai H, Yang D, Hu B, Huang X, Zhang X, Hou Y, Cai JP, Zhang AJ, Zhou J, Yuan S, To KK, Hung IF, Cheung TT, Ng AT, Hau-Yee Chan I, Wong IY, Law SY, Foo DC, Leung WK, Yuen KY. SARS-CoV-2 Induces a More Robust Innate Immune Response and Replicates Less Efficiently Than SARS-CoV in the Human Intestines: An Ex Vivo Study With Implications on Pathogenesis of COVID-19. Cell Mol Gastroenterol Hepatol. 2021;11(3):771-781. doi: 10.1016/j.jcmgh.2020.09.017. Epub 2020 Oct 1. PMID: 33010495; PMCID: PMC7527315.

66: Sridhar S, Yip CC, Wu S, Chew NF, Leung KH, Chan JF, Zhao PS, Chan WM, Poon RW, Tsoi HW, Cai JP, Chan HS, Leung AW, Tse CW, Zee JS, Tsang OT, Cheng VC, Lau SK, Woo PC, Tsang DN, Yuen KY. Transmission of Rat Hepatitis E Virus Infection to Humans in Hong Kong: A Clinical and Epidemiological Analysis. Hepatology. 2021 Jan;73(1):10-22. doi: 10.1002/hep.31138. Epub 2020 Oct 12. PMID: 31960460.