Selected Publication List


Avian influenza

Chen Y, Liang W, Yang S, Wu N, Gao H, Sheng J, Yao H, Wo J, Fang Q, Cui D, Li Y, Yao X, Zhang Y, Wu H, Zheng S, Diao H, Xia S, Zhang Y, Chan KH, Tsoi HW, Teng JL, Song W, Wang P, Lau SY, Zheng M, Chan JF, To KK, Chen H, Li L, Yuen KY. Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome. Lancet. 2013 Jun 1;381(9881):1916-25

Kao RY, Yang D, Lau LS, Tsui WH, Hu L, Dai J, Chan MP, Chan CM, Wang P, Zheng BJ, Sun J, Huang JD, Madar J, Chen G, Chen H, Guan Y, Yuen KY. Identification of influenza A nucleoprotein as an antiviral target. Nat Biotechnol. 2010 Jun;28(6):600-5.

Yuen KY, Chan PKS, Peiris M, Tsang DNC, Que TL, Shortridge KF, Cheung PT, To WK, Ho ETF, Sung R, Cheng AFB, and members of the H5N1 study group. Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus. Lancet 1998; 351(9101):467-471.

Beigel JH, Farrar J, Han AM, Hayden FG, Hyer R, de Jong MD, Lochindarat S, Nguyen TK, Nguyen TH, Tran TH, Nicoll A, Touch S, Yuen KY; Avian influenza A (H5N1) infection in humans. N Engl J Med. 2005 Sep 29; 353(13):1374-85.

Guan Y, Chen H, Li K, Riley S, Leung G, Webster R, Peiris J, Yuen KY. A model to control the epidemic of H5N1 influenza at the source. BMC Infect Dis. 2007 Nov 13;7:132.

Zheng BJ, Chan KW, Lin YP, Zhao GY, Chan C, Zhang HJ, Chen HL, Wong SSY, Lau SKP, Woo PCY, Chan KH, Jin DY, Yuen KY. Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus. Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8091-6.


Novel viruses: SARS coronavirus, human coronavirus HKU1, bat SARS coronavirus, other bat coronaviruses, and Hokovirus

Woo PC, Lau SK, Wong BH, Fan RY, Wong AY, Zhang AJ, Wu Y, Choi GK, Li KS, Hui J, Wang M, Zheng BJ, Chan KH, Yuen KY. Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5435-40.

Lau SKP, Woo PCY, Tse H, Fu CTY, Au WK, Tsoi HW, Tsang THF, Chan JSY, Tsang DNC, Tse CWS, Ng TK, Tsang OTY, Zheng BJ, Tam S, Chan XC, Zhou BP, Chan KH, Yuen KY. Identification of novel porcine and bovine parvoviruses closely related to human parvovirus 4: proposal of the genus, Hokovirus, within Parvoviridae. J Gen Virol 2008 Aug; 89(Pt 8):1840-8.

Woo PC, Wang M, Lau SK, Xu H, Poon RW, Guo R, Wong BH, Gao K, Tsoi HW, Huang Y, Li KS, Lam CS, Chan KH, Zheng BJ, Yuen KY. Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features. J Virol. 2007 Feb; 81(4):1574-85.

Woo PC, Lau SK, Yip CC, Huang Y, Tsoi HW, Chan KH, Yuen KY. Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel genotype and evidence of natural recombination in coronavirus HKU1.J Virol. 2006 Jul; 80(14):7136-45.

Lau SK, Woo PC, Li KS, Huang Y, Tsoi HW, Wong BH, Wong SS, Leung SY, Chan KH, Yuen KY. Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc Natl Acad Sci U S A. 2005 Sep 16; 102(39):14040-14045.

Woo PCY, Lau SKP, Chu CM, Chan KH, Tsoi HW, Huang Y, Wong BHL, Poon WS, Cai JJ, Luk WK, Poon LLM, Wong SSY, Guan Y, Malik JSM, Yuen KY. Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J Virol, 2005 Jan; 2(9):884-895.

Tang BS, Chan KH, Cheng VC, Woo PC, Lau SK, Lam CC, Chan TL, Wu AK, Hung IF, Leung SY, Yuen KY. Comparative host gene transcription by microarray analysis early after infection of the Huh7 cell line by severe acute respiratory syndrome coronavirus and human coronavirus 229E. J Virol. 2005 May; 79(10):6180-93.

Cheng VC, Hung IF, Tang BS, Chu CM, Wong MM, Chan KH, Wu AK, Tse DM, Chan KS, Zheng BJ, Peiris JS, Sung JJ, Yuen KY. Viral replication in the nasopharynx is associated with diarrhea in patients with severe acute respiratory syndrome. Clin Infect Dis. 2004 Feb 15; 38(4):467-75.

Woo PC, Lau SK, Tsoi HW, Chan KH, Wong BH, Che XY, Tam VK, Tam SC, Cheng VC, Hung IF, Wong SS, Zheng BJ, Guan Y, Yuen KY. Relative rates of non-pneumonic SARS coronavirus infection and SARS coronavirus pneumonia. Lancet. 2004 Mar 13; 363(9412):841-5.

I.F.N. Hung, V.C.C. Cheng, A.K.L. Wu, B.S.F. Tang, K.H. Chan, C.M. Chu, M.M.L. Wong, W.T. Hui, L.L.M. Poon, D.M.W. Tse, K.S. Chan, P.C.Y. Woo, S.K.P. Lau, J.S.M. Peiris and Yuen KY. Viral Loads in Clinical Specimens and SARS Manifestations. Emerg Infect Dis 2004 Sep; 10(9):1550-57.

Peiris JS, Lai ST, Poon LLM, Guan Y, Yam LYC, Lim W, Nicholls J, Yee WKS, Yan WW, Cheung MT, Cheng, VCC, Chan KH, Tsang, DNC, Yung RWH, Ng TK and Yuen KY. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003 April 19; 361(9366):1319-1325.

Peiris, JS, Chu CM, Cheng VCC, Chan KS, Hung IFN, Poon LLM, Law KI, Tang BSF, Hon TYW, Chan CS, Chan KH, Ng JSC, Zheng BJ, Ng ML, Lai RWM, Guan Y and Yuen KY. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet 2003 May 24; 361(9371):1767-1772.


Novel and emerging bacteria or fungus

Woo PC, Lau SK, Tse H, Teng JL, Curreem SO, Tsang AK, Fan RY, Wong GK, Huang Y, Loman NJ, Snyder LA, Cai JJ, Huang JD, Mak W, Pallen MJ, Lok S, Yuen KY. The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats. PLoS Genet. 2009 Mar;5(3):e1000416.

Woo PC, Lau SK, Teng JL, Que TL, Yung RW, Luk WK, Lai RW, Hui WT, Wong SS, Yau HH, Yuen KY; L Hongkongensis study group. Association of Laribacter hongkongensis in community-acquired gastroenteritis with travel and eating fish: a multicentre case-control study. Lancet. 2004 Jun 12; 363(9425):1941-7.

Woo PC, Wong SS, Lum PN, Hui WT, Yuen KY. Cell-wall-deficient bacteria and culture-negative febrile episodes in bone-marrow-transplant recipients. Lancet. 2001 Mar 3; 357(9257):675-9.

Yuen KY, Woo PCY, Teng JLL, Leung KW, Wong MKM, Lau SKP. Laribacter hongkongensis gen. Nov., sp. nov., a Novel gram-negative bacterium isolated from a cirrhotic patient with bacteremia and empyema. J Clin Microbiol 2001, 39:4227-4232.

Cao L, Chan CM, Lee C, Wong SS, Yuen KY. MP1 encodes an abundant and highly antigenic cell wall mannoprotein in the pathogenic fungus Penicillium marneffei. Infect Immun. 1998 Mar;66(3):966-73.

Yuen KY, Wong SS, Tsang DN, Chau PY.Serodiagnosis of Penicillium marneffei infection. Lancet. 1994 Aug 13;344(8920):444-5.