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Prof. Bojian ZHENG |
| MD, Ph.D | |
| Professor, Department of Microbiology | |
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| Email : bzheng@hkucc.hku.hk |
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Research Interests: |
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Research
Publications:
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| SARS | |
| 2006 |
Chan VSF, Chan KYK, Chen YX, Poon LL, Cheung ANY, Zheng BJ, Chan KH, Mak W, Ngan HYS, Xu XL, Screaton G, Tam PKH, Austyn JM, Chan LC, Yip SP, Peiris MJ, Khoo US, Lin SCL. Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection. Nat. Genet. 38:47-53. 2006. |
| 2006 |
He ML*, Zheng BJ*, Chen Y, Wong KL, Huang JD, Lin MM, Peng Y, Yuen KY, Sung JJY, Kung HF. Kinetics and synergistic effects of siRNAs targeting structural and replicase genes of SARS-associated coronavirus. FEBS Letters. 580:2414-2420. 2006. * Equal first-authors |
| 2006 |
Du L, Zhou Y, Wang Y, Zhang H, Ma S, Wong CKL, Wu SHW, Ng F, Huang JD, Yuen KY, Jiang S, Zhou Y, Zheng BJ*. Recombinant adeno-associated virus expressing the receptor-binding domain of severe acute respiratory syndrome coronavirus S protein elicits protective neutralizing antibodies: implication for developing SARS vaccines. Virology In press. 2006. * Corresponding author |
| 2005 |
Zheng BJ*, Guan Y, He ML, Sun HZ, Du LY, Zheng Y, Wong KL, Chen H, Chen Y, Lu L, Tanner JA, Watt RM, Niccolai N, Bernini A, Spiga O, Woo PCY, Kung HF, Yuen KY, Huang JD*. Synthetic peptides outside the spike protein heptad repeat regions as potent inhibitors of SARS-associated coronavirus. Antiviral Therapy. 10:375-385. 2005. * Corresponding author. |
| 2005 |
Tanner JA*, Zheng BJ*, Zhou J, Watt RM, Jiang JQ, Wong KL, Lin YP, Yu Lu LY, Kesel AJ, Huang JD. Bananins are Novel Adamantane-Derived Inhibitors of both the SARS Coronavirus Helicase and Replication of the SARS Coronavirus. Chem Biol 12:303-311. 2005 * Equal first-author. |
| 2005 |
Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque. Nat. Med. 11:944-951. 2005. |
| 2005 |
Qu D, Zheng BJ, Yao X, Guan Y, Yuan ZH, Zhong NS, Lu LW, Xie JP, Wen YM. Intranasal immunization with inactivated SARS-CoV (SARS-associated coronavirus) in mice induced local and serum antibodies. Vaccine 23:924-931. 2005. |
| 2005 |
Zheng BJ, Cao KY, Chan CPY, Choi JWY, Duan ZH, Gao Y, Wang M, Di B, Hollidt JM, Bergmann A, Lehmann M, Renneberg I, Tam JSL, Chan PKS, Cautherley GWH, Fuchs D, Renneberg R. Serum Neopterin for Early Assessment of Severity of Severe Acute Respiratory Syndrome. Clin Immun. 16:18-26. 2005. |
| 2005 |
Di B, Hao W, Gao Y, Wang M, Wang YD, Qiu LW, Wen K, Zhou DH, Wu XW, Lu EJ, Liao ZY, Mei YB, Zheng BJ, Che XY. Monoclonal antibody-based antigen capture enzyme-linked immunosorbent assay reveals high sensitivity of the nucleocapsid protein in acute-phase sera of severe acute respiratory syndrome patients. Clin Diagn Lab Immunol. 12:135-140. 2005. |
| 2005 |
Wang M*, Yan MY*, Xu HF*, Liang WL*, Kan B*, Zheng BJ*, Chen H, Zheng H, Xu YM, Zhang EM, Wang HX, Ye JR, Li GC, Li MC, Cui ZG, Liu YF, Guo RT, Liu XN, Zhan LH, Zhou DH, Zhao AL, Hai R, Yu DZ, Guan Y, Xu JG. Molecular evidence for patients infected at a restaurant by immature SARS-CoV from palm civet. Emerg. Infect. Dis. 11:1860-1861. 2005. * Equal first-author. |
| 2004 |
Zheng BJ, Guan Y, Tang QQ, Cheng D, Xie FY, He ML, Chan KW, Wong KL, Lader E, Woodle MC, Lu PY, Li BJ, Zhong NS. Prophylactic and Therapeutic Effects of Small Interfering RNA Targeting SARS-Coronavirus. Antiviral Ther. 9:365-374. 2004. |
| 2004 |
Guan Y, Peiris JSM, Zheng BJ, Poon LLM, Chan KH, Zeng FY, Chan CWM, Chan MN, Chen JD, Chow KYC, Hon CC, Hui KH, Li J, Li VYY, Wang Y, Leung SW, Yuen KY, Leung FC. Molecular epidemiology of the novel coronavirus that causes Severe Acute Respiratory Syndrome. Lancet. 363:99-104. 2004. |
| 2004 |
Zheng BJ, Guan Y, Wong KH, Zhou J, Wong KL, Young BWY, Lu LW, Lee SS. Community exposure to animal SCV (SARS-related coronavirus) like virus predating SARS outbreak in Hong Kong. Emerg. Infect. Dis. 10:176-178. 2004. |
| 2004 |
Woo PCY, Lau SKP, Tsoi HW, Chan KH, Wong BHL, Che XY, Tam VKP, Tam SCF, VCC, Hung IFN, Wong SSY, Zheng BJ, Guan Y, Yuen KY. Relative rates of non-pneumonic SARS coronavirus infection and SARS coronavirus pneumonia. Lancet. 363: 841-45. 2004 |
| 2004 |
Poon LL, Chan KH, Wong OK, Cheung TK, Ng I, Zheng BJ, Seto WH, Yuen KY, Guan Y, Peiris JS. Detection of SARS Coronavirus in Patients with Severe Acute Respiratory Syndrome by Conventional and Real-Time Quantitative Reverse Transcription-PCR Assays. Clin Chem. 50:67-72. 2004. |
| 2004 |
Cheng VC, Hung IF, Tang BS, Chu CM, Wong MM, Chan KH, Wu AK, Tse DM, Chan KS, Zheng BJ, Peiris JS, Sung JJ, Yuen KY. Viral replication in the nasopharynx is associated with diarrhea in patients with severe acute respiratory syndrome. Clin Infect Dis 38:467-75. 2004. |
| 2004 |
Wong ATY, Tsang OTY, Wong KH, Wong MYF, Lim WL, Zheng BJ, Lee SS, Lai ST, Yuen KY. Coronavirus infection in an AIDS patient. AIDS 18:829-830. 2004. |
| 2004 |
Zheng BJ, He ML, Wong KL, Lum CT, Leo L.M. Poon LLM, Peng Y, Guan Y, Marie C.M. Lin MCM, Kung HF. Potent Inhibition of SARS-Associated Coronavirus (SCoV) Infection and Replication by Type I Interferons (IFNα/β) but not by Type II Interferon (IFNγ). J Interferon Cytokine Res. 24:388-390. 2004. |
| 2004 |
Bernini A, Spiga O, Ciutti A, Chiellini S, Bracci L, Yan XY, Zheng BJ, Huang JD, He ML, Song HD, Hao P, Zhao GP, Niccolai N. Prediction of quaternary assembly of SARS coronavirus peplomer. Biochemical and Biophysical Research Communications. 325:1210-1214. 2004. (IF = 2.8) |
| 2004 |
Wang M, Xu HF, Mo ZY, Zheng BJ, Gu J, Qin PZ, Zhang ZB, Zou XZ, Liang CY, Zhao YT, Gao K. Anti-SARS virus antibody responses against human SARS-associated coronavirus and animal SARS-associated coronavirus-like virus. Chin Med J (Engl). 117:1723-5. 2004. |
| 2003 |
Guan Y*, Zheng BJ*, He YQ, Liu XL, Zhuang ZX, Cheung CL, Luo SW, Li PH, Zhang LJ, Guan YJ, Butt KM, Wong KL, Chan KW, Lim W, Shortridge KF, Yuen KY, Peiris JSM, Poon LLM. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science. 302:276-278. 2003. * Equal first-author |
| 2003 |
Zhong NS*, Zheng BJ*, Li YM, Poon LLM, Xie ZH, Li PH, Tan SY, Chang Q, Xie JP, Liu XQ, Xu J, Li DX, Yuen KY, Peiris JSM, Guan Y. Epidemiological and Aetiological Studies of Patients with Severe Acute Respiratory Syndrome (SARS) from Guangdong in February 2003. Lancet. 362:1353-1358. 2003. * Equal first-author |
| 2003 |
He ML*, Zheng BJ*, Peiris JSM, Lin MCM, Peng Y, Poon LLM, Kwok Y Yuen KY, Kung HF, Guan Y. Inhibition of SARS-Associated Coronavirus Infection and Replication by RNA Interference. JAMA. 290:2665-2666. 2003. * Equal first-author |
| 2003 |
Peiris JS, Chu CM, Cheng VC, Chan KS, Hung IF, Poon LL, Law KI, Tang BS, Hon TY, Chan CS, Chan KH, Ng JS, Zheng BJ, Ng WL, Lai RW, Guan Y, Yuen KY; HKU/UCH SARS Study Group. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet. 361:1767-1772. 2003. |
| 2003 |
Zeng FY, Chan CW, Chan MN, Chen JD, Chow KY, Hon CC, Hui KH, Li J, Li VY, Wang CY, Wang PY, Guan Y, Zheng B, Poon LL, Chan KH, Yuen KY, Peiris JS, Leung FC. The Complete Genome Sequence of Severe Acute Respiratory Syndrome Coronavirus Strain HKU-39849 (HK-39). Exp Biol Med (Maywood). 228:866-873. 2003. |
| HIV | |
| 2006 |
Yam WC, Chen JHK, Wong KH, Chan K, Cheng VCC, Lam HY, Lee SS, Zheng BJ, Yuen KY. Clinical utility of genotyping resistance test on determining the mutation patterns in HIV-1 CRF01_AE and subtype B patients receiving antiretroviral therapy in Hong Kong. J Clin Virol. 35:454-457. 2006. |
| 2005 |
Zhao XY, Lee SS, Wong KH, Chan KCW, Ng F, Chan CCS, Han D, Yam WC, Yuen KY, Ng MH, Zheng BJ*. Functional analysis of naturally occurring mutations in open reading frame of CCR5 in Chinese HIV patients and healthy controls. JAIDS. 38:509-517. 2005. * Corresponding author |
| 2004 |
Zhao XY, Lee SS, Wong KH, Chan KCW, He ZM, Ma S, Ng F, Chan CCS, Ho T, Ng MH, Zheng BJ*. A novel CCR5 mutation selectively affects immunoreactivity and fusogenic property of the HIV co-receptor in a slow progressing HIV patient. AIDS. 18:1729-1732. 2004. * Corresponding author |
| 2004 |
Zhao XY, Lee SS, Wong KH, Chan KCW, Ma S, Yam WC, Yuen KY, MH, Zheng BJ*. Single nucleotide polymorphism in the RANTES promoter region in healthy and HIV infected indigenous Chinese. Eur. J Immunogenet. 31:179-183. 2004. * Corresponding author |
| 2002 |
Zheng BJ, Zhao XY, Zhu NS, Chan CP, Wong KH,Chan KCW, Yam WC, Yuen KY, Lee SS. Polymorphism of CCR5 Gene in Southern Chinese population and the Effects on Disease Progression in HIV Patients. AIDS 16:2480-2482. 2002. |
| HBV | |
| 2006 | Yuen MF, Wong DKH, Zheng BJ, Chan CCS, Yuen JCH, Wong BCY, Lai CL. Difference in T Helper Responses During Hepatitis Flares in HBeAg-positive Patients with Genotypes B and C: Implication for Early HBeAg Seroconversion. J Viral Hepat. In press. |
| 2005 | Duan ZP, Zhao XY, Huang DZ, He LX, Yu Chen Y, Zhao CH, Zheng BJ*. RANTES gene single nucleotide polymorphisms and expression in chronic Hepatitis B Virus infection. Chin Med J (Engl). 118:909-914. 2005 * Corresponding author |
| 2004 | Zheng BJ, Zhou J, Qu D, Siu KL, Lam TW, Lo HY, Lee SS, Wen YM. Selective Functional Deficit in Dendritic Cell – T Cell Interaction Is a Crucial Mechanism in Chronic Hepatitis B Virus Infection. J. Viral Hepat. 11:217–224. 2004. |
| 2002 | Zheng BJ, Ng MH, Chan KW, Tam S, Woo PCY, Ng SP, Yuen KY. A Single Dose of Oral DNA Immunization Delivered by Attenuated Salmonella typhimurium Down-regulates Transgene Expression in HBsAg Transgenic Mice Eur J Immun. 32:3294-3304. 2002. |
| 2002 | Zheng BJ, Woo PCY, Ng MH, Tsoi HW, Wong LP, Yuen KY. A crucial role of macrophage in the immune responses to oral vaccination against hepatitis B virus in a murine model. Vaccine 20:140-147. 2002. |
| 2001 | Zheng BJ, Ng MH, He LF, Yao X, Chan KW, Yuen KY, Wen YM. Therapeutic efficacy of hepatitis B surface antigen-antibody-recombinant composite in HBsAg transgenic mice. Vaccine 19:4219-4225. 2001. |
| 2001 |
Woo PCY, Wong LP, Zheng BJ, Yuen KY. Unique immunogenicity of hepatitis B virus DNA vaccine presented by liver-attenuated Salmonella typhimurium. Vaccine 19:2945-2954. 2001. |
| EBV and NPC | |
| 2006 | Zheng Y, Cao KY, Ng SP, Daniel T.T. Chua DTT, Sham JST, Kwong DLW, Ng MH, Lu LW*, Zheng BJ*. A complementary activation of peripheral NK cell immunity in nasopharyngeal carcinoma. Cancer Science. In press. * Corresponding author |
| 2002 | Zheng BJ, Ng SP, Daniel T.T. Chua DTT, Sham JST, Dora L.W. Kwong DLW, Lam CK, Ng MH. Peripheral gd T Cell Deficit in Nasopharyngeal Carcinoma. Int J Cancer 99:213-217. 2002. |
| 2002 |
Cheng WM, Chan WH, Chen HL, Luo RX, Ng SP, Luk W, Zheng BJ, Ji MF, Liang JS, Sham JST, Wang DK, Hon Ng MH. Assessing the risk of nasopharyngeal carcinoma on the basis of EBV antibody spectrum. Int J Cancer 97:489-492. 2002. |
| 2001 | Zheng BJ, Chan KW, Im S, Chua D, Sham JST, Tin PC, He ZM, Ng MH. Anti-tumor effect of human peripheral gd T cells in nude mouse model. Int. J. Cancer. 92:421-425. 2001. |
| 2001 |
Zheng BJ, Lam C, Im S, Huang J, Luk W, Lau SY, Yau KS, Wong CK, Yao K, Ng MH. Distinct tumor specificity and IL-7 requirements of CD56- and CD56+ subsets of human gd T cells. Scan J Immunol. 53:40-48. 2001. |
| 2001 |
Chua D, Huang J, Zheng BJ, Lau SY, Luk W, Kwong DLW, Sham JST, Moss D, Yuen KY, Im S, Ng MH. Adoptive transfer of autologous EBV specific cytotoxic T cells for nasopharyngeal carcinoma. Int J Cancer 94:73-80. 2001. |