Research
Interests:
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Research
Interests:
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Emerging antibiotic resistance: Detection, epidemiology, clinical impact and genetics of quinolone-resistant Streptococcus pneumoniae, novel b-lactamases in Enterobacteriaceae and Burkholderia pseudomallei, and glycopeptide resistance in staphylococci and enterococci. |
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Containment of antimicrobial resistance: the link between usage and resistance pattern, optimization of antimicrobial therapy and antimicrobial strategies |
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Respiratory tract infections: The spectrum of infections in patients with chronic obstructive pulmonary disease and bronchiectasis. |
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Emerging infectious diseases: bacterial contaminations of blood products, and relation of influenza activity to drug-resistant Streptococcus pneumoniae |
| Year |
Publication
in Books
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| 2002 |
Ho PL, VCC Cheng. Epidemiology and mechanisms of resistance. In DE Low, A Ronald (ed.). The Quinolones: an unfolding story. Biosciences. Birkhauser, Verlag AG. (in press) |
| 2000 |
Tsang KWT, Ho PL, Ip M. Opportunistic pulmonary infections. In Clinical Respiratory Medicine. 2nd ed, 2000. The Central Printing Press Ltd. |
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Publications
in Journals
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ANTIMICROBIAL
RESISTANCE
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| 2002 |
Ho PL*, Cheung TKM, Yam WC, Yuen KY. Characterization of a laboratory-generated variant of BPS -lactamase from Burkholderia pseudomallei that hydrolyzes ceftazidime. . J Antimicrob Chemother (in press). |
| 2002 |
Ho PL*, Chan WM, Tsang KWT, Wong SSY, Young K. Risk Factors for and Outcome of Bloodstream Infection by Escherichia coli Producing Extended-Spectrum Beta-Lactamase. (in press) |
| 2002 |
Cheung TKM, Ho PL*, Woo PCY, Yuen KY, Chau PY. Cloning And Expression
Of |
| 2002 | Ho PL*, Cheung TKM, Kinoshita R, Tse CWS, Yuen KY. Activity of five fluoroquinolones against 71 isolates of Burkholderia pseudomallei. J Antimicrob Chemother 2002;49:1042-1043 |
| 2001 | PL Ho*, RWH Yung, DNC Tsang, TL Que, M Ho,
WH Seto, TK Ng, WC Yam, Wilson WS Ng. Increasing resistance of Streptococcus pneumoniae to fluoroquinolones: results of a Hong Kong multi-centre study in 2000. J Antimicrob Chemother 2001:48:659-665. |
| 2001 | Chiu, S. S., Ho P. L.*, Chow F. K., Yuen K.
Y., & Lau Y. L.. Nasopharyngeal Carriage of Antimicrobial-Resistant Streptococcus pneumoniae among Young Children Attending 79 Kindergartens and Day Care Centers in Hong Kong. 2001 Antimicrob.Agents Chemother. 45, 2765-70. |
| 2001 | Ho PL, Yam WC, TKM Cheung, WWS Ng, TL Que,
DNC Tsang, TK Ng, WH Seto. Fluoroquinolone resistance among Streptococcus pneumoniae in Hong Kong linked to the Spanish 23F clone. Emerg Infect Dis 2001;7:906-908. |
| 2001 | PL Ho, WC Yam, TL Que, DNC Tsang, WH Seto,
TK Ng, WS Ng. Target site modifications and efflux phenotype in clinical isolates of Streptococcus pneumoniae from Hong Kong with reduced susceptibility to fluoroquinolones. J Antimicrob Chemother 2001;47:655-8 |
| 2001 | PL Ho*, WS Tse, KWT Tsang, TK Kwok, TK Ng, VCC Cheng, RMT Chan. Risk factors for acquisition of levofloxacin?Resistant Streptococcus pneumoniae: Case-Control Study. Clin Infect Dis 2001;32:701-7. |
| 2000 | LK Siu, JYC Lo, KY Yuen, PY Chau, MH Ng and P L
Ho.*b-Lactamases in Shigella flexneri isolates from Hong Kong and Shanghai and a novel OXA?1-like b-lactamase, OXA?30. Antimicrob Agents Chemother 2000;44:2034-8. |
| 2000 | Ho PL*, Tsang DNC, Que TL, Ho M, Yuen KY. Comparison
of screening methods for detection of extended-spectrum beta-lactamases and their prevalence among Escherichia coli and Klebsiella species in Hong Kong. APMIS 2000; 108: 237-40. |
| 1999 | Wong SSY, Woo PCY, Ho PL, Cheng VCC, Yuen KY.
Emergence of Streptococcus pneumoniae with high level resistance to cefotaxime in Hong Kong. Hong Kong Medical Journal 1999; 5: 406-409. |
| 1999 | Wong SSY, Ho PL, Woo PCY, Yuen KY. Bacteremia
caused by inducible vancomycin heteroresistant staphylococci. Clin Infect Dis 1999; 29: 760-7. |
| 1999 | LK Siu, JYC Lo, WL Cheng, Ho PL, WS Ng, PY
Chau. An evaluation of susceptibility testing methods for ampicillin-sulbactam using a panel of b-lactamase-producing bacteria. APMIS 1999; 107: 703-8. |
| 1999 | Ho PL*, Que TL, Tsang DNC, Ng TK, Chow KH,
Seto WH. Emergence of fluoroquinolone resistance among multiply resistant strains of Streptococcus pneumoniae in Hong Kong. Antimicrob Agents Chemother 1999; 43: 1310-3. |
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INFECTIOUS
DISEASES
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| 2001 | Woo PC, Leung PK, Wong SS, Ho PL,
Yuen KY. groEL Encodes a Highly Antigenic Protein in Burkholderia pseudomallei. Clin Diagn Lab Immunol 2001; 8:832-36. |
| 2001 | Tang, W. M., Ho P. L., Fung K.
K., Yuen K. Y., & Leong J. C. (2001). Necrotising fasciitis of a limb. J Bone Joint Surg.Br. 83, 709-14. |
| 2001 | Cheng, V. C., Yuen K. Y., Wong S. S., Woo P. C., Ho
P. L., Lee R. et al. (2001). Immunorestitution diseases in patients not infected with HIV. Eur.J Clin Microbiol.Infect Dis 20, 402-6. |
| 2001 | Tang S, Kwok TK, Ho PL, Tang WM, Chan TM, Lai
KN. Necrotizing fasciitis in a renal transplant recipient treated with FK 506: the first reported case. Clinical Nephrology 2001;56:481-5. |
| 2000 | Ho PL*, WM Tang, KY Yuen. Klebsiella pneumoniae
necrotizing fasciitis associated with diabetes and liver cirrhosis. Clin Infect Dis 2000;30:989-90. |
| 2000 | Ho PL, KY Yuen. Invasive aspergillosis in bone
marrow transplant recipients. Crit Rev Oncol Hematol. 2000; 34:55-69. |
| 2000 | Ho PL, P Ho, BKK Fung, WY Ip, SSY Wong. A case
of dissemination of Mycobacterium marinum infection following the use of steroid. Scand J Infect Dis 2001;33: 232-233. |
| 2000 | Ho PL, Chim CS, Yuen KY. Isolated splenic tuberculosis
presenting with pyrexia of unknown origin. Scand J of Infect Dis 2000;32:700-1. |
| 2000 | Tang WM, Ho PL, Yip KH, Yau WP,
Wong WK. Severe Musculoskeletal infections caused by group B streptococcus: Necrotizing Fasciitis and Septic Arthritis. Clin Infect Dis 2000; 31:e15-17. |
| 1999 | Chim CS, Ho PL, Yuen KY, JSM Pieres. Herpes
simplex encephalitis in multiple myeloma. Aust N J Med 1999; 29:381. |
| 1999 | Liu HW, Tammy SY Cheung, KY Yuen, KB Lee, Elizabeth
KM Chua, Ho PL, CK Lin. Reduction of platelet transfusion-associated sepsis by short-term bacterial culture. Vox Sanguinis 1999; 77: 1-5. |
| 1999 |
H Siau, KY Yuen, Ho PL, SSY Wong, PCY Woo.
Acinetobacter bacteremia in Hong Kong: prospective study and review. Clin Infect Dis 1999; 28: 26-30. |
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RESPIRATORY
TRACT INFECTIONS
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| 1999 | Tsang KWT, Ho PL, Ip MSM, Lam WK,
Yuen KY. A pilot study of low-dose erythromycin in bronchiectasis. Eur J Respir 1999; 13: 361-4. |
| 1999 | KWT Tsang, WM Chan, Ho PL, KN Chan, M Ip. A
comparative study on the efficacy of levofloxacin and ceftazidime on acute exacerbation of bronchiectasis. Eur Repir J 1999; 14: 1206-1209 |
| 1999 | Tsang KWT, Chan KN, Ho PL, Ooi GC, Zheng L,
Lam B, Ho JCM, Lam WK. Sputum elastase in steady state bronchiectasis. Chest 2000; 117:420-426 |