Dr. PL. HO
Clinical Associate Professor,Department of Microbiology
Homepage: http://www.hku.hk/hkucoi/



Research Interests:
Emerging antibiotic resistance: Detection, epidemiology, clinical impact and genetics of quinolone-resistant Streptococcus pneumoniae, novel b-lactamases in Enterobacteriaceae and Burkholderia pseudomallei, and glycopeptide resistance in staphylococci and enterococci.
Containment of antimicrobial resistance: the link between usage and resistance pattern, optimization of antimicrobial therapy and antimicrobial strategies
Respiratory tract infections: The spectrum of infections in patients with chronic obstructive pulmonary disease and bronchiectasis.
Emerging infectious diseases: bacterial contaminations of blood products, and relation of influenza activity to drug-resistant Streptococcus pneumoniae

Publication in Books

Ho PL, VCC Cheng. Epidemiology and mechanisms of resistance. In DE Low, A Ronald (ed.). The Quinolones: an unfolding story. Biosciences. Birkhauser, Verlag AG. (in press)


Tsang KWT, Ho PL, Ip M. Opportunistic pulmonary infections. In Clinical Respiratory Medicine. 2nd ed, 2000. The Central Printing Press Ltd.

Publications in Journals

Ho PL*, Cheung TKM, Yam WC, Yuen KY. Characterization of a laboratory-generated variant of BPS -lactamase from Burkholderia pseudomallei that hydrolyzes ceftazidime. . J Antimicrob Chemother (in press).


Ho PL*, Chan WM, Tsang KWT, Wong SSY, Young K. Risk Factors for and Outcome of Bloodstream Infection by Escherichia coli Producing Extended-Spectrum Beta-Lactamase. (in press)


Cheung TKM, Ho PL*, Woo PCY, Yuen KY, Chau PY. Cloning And Expression Of
The Class A Lactamase Gene, BlaABPS In Burkholderia Pseudomallei
Antimicrob. Agents Chemother. 2002;46:11325

2002 Ho PL*, Cheung TKM, Kinoshita R, Tse CWS, Yuen KY. Activity of five fluoroquinolones against 71 isolates of Burkholderia pseudomallei. J Antimicrob Chemother 2002;49:1042-1043
2001 PL Ho*, RWH Yung, DNC Tsang, TL Que, M Ho, WH Seto, TK Ng, WC Yam, Wilson
WS Ng. Increasing resistance of Streptococcus pneumoniae to fluoroquinolones: results
of a Hong Kong multi-centre study in 2000. J Antimicrob Chemother 2001:48:659-665.
2001 Chiu, S. S., Ho P. L.*, Chow F. K., Yuen K. Y., & Lau Y. L.. Nasopharyngeal Carriage
of Antimicrobial-Resistant Streptococcus pneumoniae among Young Children Attending
79 Kindergartens and Day Care Centers in Hong Kong. 2001 Antimicrob.Agents
Chemother. 45, 2765-70.
2001 Ho PL, Yam WC, TKM Cheung, WWS Ng, TL Que, DNC Tsang, TK Ng, WH Seto.
Fluoroquinolone resistance among Streptococcus pneumoniae in Hong Kong linked to
the Spanish 23F clone. Emerg Infect Dis 2001;7:906-908.
2001 PL Ho, WC Yam, TL Que, DNC Tsang, WH Seto, TK Ng, WS Ng. Target site
modifications and efflux phenotype in clinical isolates of Streptococcus pneumoniae from
Hong Kong with reduced susceptibility to fluoroquinolones. J Antimicrob Chemother
2001 PL Ho*, WS Tse, KWT Tsang, TK Kwok, TK Ng, VCC Cheng, RMT Chan. Risk factors for acquisition of levofloxacin?Resistant Streptococcus pneumoniae: Case-Control Study. Clin Infect Dis 2001;32:701-7.
2000 LK Siu, JYC Lo, KY Yuen, PY Chau, MH Ng and P L Ho.*b-Lactamases in Shigella
flexneri isolates from Hong Kong and Shanghai and a novel OXA?1-like b-lactamase,
OXA?30. Antimicrob Agents Chemother 2000;44:2034-8.
2000 Ho PL*, Tsang DNC, Que TL, Ho M, Yuen KY. Comparison of screening methods for
detection of extended-spectrum beta-lactamases and their prevalence among Escherichia
coli and Klebsiella species in Hong Kong. APMIS 2000; 108: 237-40.
1999 Wong SSY, Woo PCY, Ho PL, Cheng VCC, Yuen KY. Emergence of Streptococcus
pneumoniae with high level resistance to cefotaxime in Hong Kong. Hong Kong Medical
Journal 1999; 5: 406-409.
1999 Wong SSY, Ho PL, Woo PCY, Yuen KY. Bacteremia caused by inducible vancomycin
heteroresistant staphylococci. Clin Infect Dis 1999; 29: 760-7.
1999 LK Siu, JYC Lo, WL Cheng, Ho PL, WS Ng, PY Chau. An evaluation of susceptibility
testing methods for ampicillin-sulbactam using a panel of b-lactamase-producing
bacteria. APMIS 1999; 107: 703-8.
1999 Ho PL*, Que TL, Tsang DNC, Ng TK, Chow KH, Seto WH. Emergence of
fluoroquinolone resistance among multiply resistant strains of Streptococcus pneumoniae
in Hong Kong. Antimicrob Agents Chemother 1999; 43: 1310-3.
2001 Woo PC, Leung PK, Wong SS, Ho PL, Yuen KY. groEL Encodes a Highly Antigenic
Protein in Burkholderia pseudomallei. Clin Diagn Lab Immunol 2001; 8:832-36.
2001 Tang, W. M., Ho P. L., Fung K. K., Yuen K. Y., & Leong J. C. (2001). Necrotising
fasciitis of a limb. J Bone Joint Surg.Br. 83, 709-14.
2001 Cheng, V. C., Yuen K. Y., Wong S. S., Woo P. C., Ho P. L., Lee R. et al. (2001).
Immunorestitution diseases in patients not infected with HIV. Eur.J Clin Microbiol.Infect
Dis 20, 402-6.
2001 Tang S, Kwok TK, Ho PL, Tang WM, Chan TM, Lai KN. Necrotizing fasciitis in a renal
transplant recipient treated with FK 506: the first reported case. Clinical Nephrology
2000 Ho PL*, WM Tang, KY Yuen. Klebsiella pneumoniae necrotizing fasciitis associated
with diabetes and liver cirrhosis. Clin Infect Dis 2000;30:989-90.
2000 Ho PL, KY Yuen. Invasive aspergillosis in bone marrow transplant recipients. Crit Rev
Oncol Hematol. 2000; 34:55-69.
2000 Ho PL, P Ho, BKK Fung, WY Ip, SSY Wong. A case of dissemination of
Mycobacterium marinum infection following the use of steroid. Scand J Infect Dis
2001;33: 232-233.
2000 Ho PL, Chim CS, Yuen KY. Isolated splenic tuberculosis presenting with pyrexia of
unknown origin. Scand J of Infect Dis 2000;32:700-1.
2000 Tang WM, Ho PL, Yip KH, Yau WP, Wong WK. Severe Musculoskeletal infections
caused by group B streptococcus: Necrotizing Fasciitis and Septic Arthritis. Clin Infect
Dis 2000; 31:e15-17.
1999 Chim CS, Ho PL, Yuen KY, JSM Pieres. Herpes simplex encephalitis in multiple
myeloma. Aust N J Med 1999; 29:381.
1999 Liu HW, Tammy SY Cheung, KY Yuen, KB Lee, Elizabeth KM Chua, Ho PL, CK Lin.
Reduction of platelet transfusion-associated sepsis by short-term bacterial culture. Vox
Sanguinis 1999; 77: 1-5.
H Siau, KY Yuen, Ho PL, SSY Wong, PCY Woo. Acinetobacter bacteremia in Hong
Kong: prospective study and review. Clin Infect Dis 1999; 28: 26-30.
1999 Tsang KWT, Ho PL, Ip MSM, Lam WK, Yuen KY. A pilot study of low-dose
erythromycin in bronchiectasis. Eur J Respir 1999; 13: 361-4.
1999 KWT Tsang, WM Chan, Ho PL, KN Chan, M Ip. A comparative study on the efficacy of
levofloxacin and ceftazidime on acute exacerbation of bronchiectasis. Eur Repir J 1999;
14: 1206-1209
1999 Tsang KWT, Chan KN, Ho PL, Ooi GC, Zheng L, Lam B, Ho JCM, Lam WK. Sputum
elastase in steady state bronchiectasis. Chest 2000; 117:420-426