Prof. Patrick CY WOO

 

 MBBS (HK), MD (HK), FRCPath (UK), FRCP (Glas)

 

 Clinical Professor, Department of Microbiology

 

Email : pcywoo@hkucc.hku.hk

 

 

 

Research Interests:

 

Emerging infectious diseases, novel microbes discovery and microbial genomics

 

Our laboratory uses a wide range of molecular techniques, immunological techniques and bioinformatics tools to discover and characterize emerging pathogens and novel causes of unexplained infectious disease syndromes.

 Representative Publications:

2014

Woo PCY, Lau SKP, Lam CSF, Tsang AKL, Hui SW, Fan RYY, Martelli P, Yuen KY. Discovery of a novel bottlenose dolphin coronavirus reveals a distinct species of marine mammal coronavirus in Gammacoronavirus. Journal of Virology 2014; 88: 1318-1331.

2013

Lau SKP, Tse H, Chan JS, Zhou AC, Curreem SOT, Lau CCY, Yuen KY, Woo PCY (corresponding author). Proteome profiling of the dimorphic fungus Penicillium marneffei extracellular proteins and identification of glyceraldehyde-3-phosphate dehydrogenase as an important adhesion factor for conidial attachment. FEBS Journal 2013; 280: 6613-6626.

2013

Lau SKP, Chow FWN, Wong AYP, Yeung J, Bao A, Luk Z, Lok S, Woo PCY (corresponding author), Yuen KY. Identification of microRNA-like RNAs in mycelial and yeast phases of the thermal dimorphic fungus Penicillium marneffei. PLoS Neglected Tropical Diseases 2013; 7: e2398. 

2013

Lau SKP, Li KSM, Tsang AKL, Lam CSF, Ahmed S, Chen H, Chan KH, Woo PCY (corresponding author), Yuen KY. Genetic characterization of Betacoronavirus lineage C viruses in bats revealed marked sequence divergence in the spike protein of Pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications on the origin of the novel Middle East Respiratory Syndrome Coronavirus. Journal of Virology 2013; 87: 8638-8650.

2013

Lau SKP, Curreem SOT, Lin CC, Fung AMY, Yuen KY, Woo PCY (corresponding author). Streptococcus hongkongensis sp. nov. isolated from a patient with infected puncture wound and marine flatfish. International Journal of Systematic and Evolutionary Microbiology 2013; 63: 2570-2576.

2013

Guo FB, Xiong LF, Teng JLL, Yuen KY, Lau SKP, Woo PCY (corresponding author). Re-annotation of protein-coding genes in 10 complete genomes of Neisseriaceae family by combining similarity-based and composition-based methods. DNA Research 2013; 20: 273-286.

2013

Woo PCY (corresponding author), Ngan AHY, Tsang CCC, Ling IWH, Chan JFW, Leung SY, Yuen KY, Lau SKP. Clinical spectrum of Exophiala infections and a novel Exophiala species, Exophiala hongkongensis. Journal of Clinical Microbiology 2013; 51: 260-267. 

2012

Woo PCY (corresponding author), Lam CW, Tam EWT, Leung CKF, Wong SSY, Lau SKP, Yuen KY. First discovery of two polyketide synthase genes for mitorubrinic acid and mitorubrinol yellow pigment biosynthesis and implications in virulence of Penicillium marneffei. PLoS Neglected Tropical Diseases 2012; 6: e1871.

2012

Lau SKP, Li KS, Tsang AK, Shek CT, Wang M, Choi GKY, Guo R, Wong BHL, Poon RWS, Lam CSF, Wang SY, Fan RYY, Chan KH, Zheng BJ, Woo PCY (corresponding author), Yuen KY. Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to Pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders. Journal of Virology 2012; 86: 11906-11918.

2012

Lau SKP, Fan RYY, Lo HW, Ng RHY, Wong SSY, Li IWS, Wu AKL, Ng KHL, Tseung S,  Lee RA, Fung KSC, Que TL, Yuen KY, Woo PCY (corresponding author). High mortality associated with Catabacter hongkongensis bacteremia. Journal of Clinical Microbiology 2012; 50: 2239-2243.

2012

Woo PCY, Lau SKP, Wong BHL, Wu Y, Lam CSF, Yuen KY. Novel variant of Beilong paramyxovirus in rats, China. Emerging Infectious Diseases 2012; 18: 1022-1024.

2012

Woo PCY (corresponding author), Lau SKP, Bai Ru, Teng JLL, Lee P, Hui SW, Martelli P, Yuen KY. Complete genome sequence of a novel picobirnavirus, otarine picobirnavirus, discovered in California sea lions. Journal of Virology 2012; 86: 6377-6378.

2012

Lau SKP, Woo PCY (co-first author), Yip CCY, Fan RYY, Huang Y, Wang M, Guo R, Lam CS, Tsang AKL, Lai KK, Chan KH, Che XY, Zheng BJ, Yuen KY. Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits. Journal of Virology 2012; 86: 5481-5496.

2012

Woo PCY, Lau SKP, Wong BHL, Fan RYY, Wong AYP, Zhang AJX, Wu Y, Choi GKY, Li KSM, Hui J, Wang M, Zheng BJ, Chan KH, Yuen KY. Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats. Proceedings of the National Academy of Sciences of the USA 2012; 109: 5435-5440.

2012

Woo PCY, Lau SKP, Lam CSF, Lau CCY, Tsang AKL, Lau JHN, Bai R, Teng JLL, Tsang CCC, Wang M, Zheng BJ, Chan KH, Yuen KY. Discovery of seven novel mammalian and avian coronaviruses in Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus. Journal of Virology 2012; 86: 3995-4008.

2012

Woo PCY, Lau SKP, Choi GKY, Yip CCY, Huang Y, Tsoi HW, Yuen KY. Complete genome sequence of a novel picornavirus, canine picornavirus, discovered in dogs. Journal of Virology 2012; 86: 3402-3403

2012

Woo PCY, Lau SKP, Choi GKY, Huang Y, Teng JLL, Tsoi HW, Yeung ML, Chan KH, Jin DY, Yuen KY. Natural occurrence and characterization of two IRES elements in a novel virus, canine picodicistrovirus, in the picornavirus-like superfamily. Journal of Virology 2012; 86: 2797-2808.

2012

Lau SKP, Woo PCY (co-first author), Yip CC, Choi GKY, Wu Y, Bai R, Fan RYY, Lai KKY, Chan KH, Yuen KY. Identification of a novel feline picornavirus from the domestic cat. Journal of Virology 2012; 86: 395-405.

2011

Woo PCY, Lau SKP, Liu B, Cai JJ, Chong KTK, Tse H, Kao RYT, Chan CM, Chow WN, Yuen KY. Draft genome sequence of Penicillium marneffei strain PM1. Eukaryotic Cell 2011; 10: 1740-1741. 

2011

Woo PCY, Lau SKP, Wong BHL, Wong AYP, Poon RWS, Yuen KY. Complete genome sequence of a novel paramyxovirus, Tailam virus, discovered in Sikkim rats. Journal of Virology 2011; 85: 13473-13474.

2011

Lau SKP, Lee P, Tsang AKL, Yip CCY, Tse H, Lee R, So LY, Lau YL, Chan KH, Woo PCY (corresponding author), Yuen KY. Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination. Journal of Virology 2011; 85: 11325-11337.

2011

Lau SKP, Woo PCY (co-first author), Lai KKY, Huang Y, Yip CCY, Shek CT, Lam CSF, Chan KH, Yuen KY. Complete genome analysis of three novel picornaviruses from diverse bat species. Journal of Virology 2011; 85: 8819-8828.

2011

Woo PCY (corresponding author), Teng JLL, Yeung JMY, Tse H, Lau SKP, Yuen KY. Automated identification of medically important bacteria by 16S rRNA gene sequencing using a novel comprehensive database 16SpathDB. Journal of Clinical Microbiology 2011; 49: 1799-1809.

2010

Woo PCY, Tam EWT, Chong KTK, Cai JJ, Tung ETK, Ngan AHY, Lau SKP, Yuen KY. High diversity of polyketide synthase genes and the melanin biosynthesis gene cluster in Penicillium marneffei. FEBS Journal 2010; 277: 3750-3758. 

2010

Woo PCY (corresponding author), Lin AWC, Lau SKP, Yuen KY. Acupuncture transmitted infections. British Medical Journal 2010; 340: 1151-1152.

2010

Lau SKP, Poon RWS, Wong BHL, Wang M, Huang Y, Xu H, Guo R, Li KSM, Gao K, Chan KH, Zheng BJ, Woo PCY (corresponding author), Yuen KY. Co-existence of different genotypes in the same bat and serological characterization of Rousettus bat coronavirus HKU9 belonging to a novel Betacoronavirus subgroup. Journal of Virology 2010; 84: 11385-11394.

2010

Lau SKP, Li KSM, Huang Y, Shek CT, Tse H, Wang M, Choi GKY, Xu H, Lam CSF, Guo R, Chan KH, Zheng BJ, Woo PCY (corresponding author), Yuen KY. Eco-epidemiology and complete genome comparison of severe acute respiratory syndrome-related Rhinolophus bat coronavirus in China reveal bats as reservoir for acute, self-limiting infection that allows recombination events. Journal of Virology 2010; 84: 2808-2819.

2009

Woo PCY, Lau SKP, Tse H, Teng JLL, Curreem SOT, Tsang AKL, Fan RYY, Wong GKM, Huang Y, Loman NJ, Snyder LAS, Cai JJ, Huang JD, Mak W, Pallen MJ, Lok S, Yuen KY. The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats. PLoS Genetics 2009; 5: e1000416.

2009

Woo PCY, Lau SKP, Lam CSF, Lai KKY, Huang Y, Lee P, Luk GSM, Dyrting KC, Chan KH, Yuen KY. Comparative analysis of complete genome sequences of three avian coronaviruses reveals a novel group 3c coronavirus. Journal of Virology 2009; 83: 908-917.

2008

Woo PCY, Lau SKP, Teng JLL, Tse H, Yuen KY. Then and now: use of 16S rDNA gene sequencing for bacterial identification and discovery of novel bacteria in clinical microbiology laboratories. Clinical Microbiology and Infection 2008; 14: 908-934. 

2008

Huang Y, Lau SKP, Woo PCY (corresponding author), Yuen KY. CoVDB: a comprehensive database for comparative analysis of coronavirus genes and genomes. Nucleic Acids Research 2008; 36: D504-511.

2007

Woo PCY, Lau CCY, Chong KTK, Tse H, Tsang DNC, Lee RA, Tse CWS, Que TL, Chung LMC, Ngan AHY, Hui WT, Wong SSY, Lau SKP, Yuen KY. MP1 homologue-based multilocus sequence typing system for typing the pathogenic fungus Penicillium marneffei: a novel approach using lineage-specific genes. Journal of Clinical Microbiology 2007; 45: 3647-3654.

2007

Lau SKP, Yip CCY, Tsoi HW, Lee RA, So LY, Lau YL, Chan KH, Woo PCY (corresponding author), Yuen KY. Clinical features and complete genome characterization of a distinct human rhinovirus (HRV) genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children. Journal of Clinical Microbiology 2007; 45: 3655-3664.

2007

Lau SKP, Yip CCY, Que TL, Lee RA, Au-Yeung RKH, Zhou B, So LY, Lau YL, Chan KH, Woo PCY (corresponding author), Yuen KY. Clinical and molecular epidemiology of human bocavirus in respiratory and fecal samples from children in Hong Kong. Journal of Infectious Diseases 2007; 196: 986-993.

2007

Woo PCY, Wang M, Lau SKP, Xu H, Poon RWS, Guo R, Wong BHL, Gao K, Tsoi HW, Huang Y, Li KSM, Lam CSF, Chan KH, Zheng BJ, Yuen KY. Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features. Journal of Virology 2007; 81: 1574-1585.

2007

Lau SKP, MaNabb A, Woo GKS, Hoang L, Fung AMY, Chung LM,
Woo PCY (corresponding author), Yuen KY. Catabacter hongkongensis gen. nov. sp. nov. isolated from blood cultures of patients in Hong Kong and Canada. Journal of Clinical Microbiology 2007; 45: 395-401.

2006

Woo PCY, Chong KTK, Tse H, Cai JJ, Lau CCY, Zhou AC, Lau SKP, Yuen KY. Genomic and experimental evidence for a potential sexual cycle in the pathogenic thermal dimorphic fungus Penicillium marneffei. FEBS Letters 2006; 580: 3409-3416.

2006

Woo PCY, Lau SKP, Yip CCY, Huang Y, Tsoi HW, Chan KH, Yuen KY. Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel genotype and evidence of natural recombination in coronavirus HKU1. Journal of Virology 2006; 80: 7136-7145.

2005

Lau SKP, Woo PCY (Co-first author), Li KSM, Huang Y, Tsoi HW, Wong BHL, Wong SSY, Leung SY, Chan KH, Yuen KY. Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proceedings of the National Academy of Sciences of the USA 2005; 102: 14040-14045.

2005

Woo PCY, Lau SKP, Chu CM, Chan KH, Tsoi HW, Huang Y, Wong BHL, Poon RWS, Cai JJ, Luk WK, Poon LLM, Wong SSY, Guan Y, Malik JSM, Yuen KY. Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. Journal of Virology 2005; 79: 884-895.

2004

Woo PCY, Lau SKP, Teng JLL, Que TL, Yung RWH, Luk WK, Lai RWM, Hui WT, Wong SSY, Yau HH, Yuen KY. Association of Laribacter hongkongensis in community-acquired gastroenteritis with travel and eating fish: a multicentre case-control study. Lancet 2004; 363: 1941-1947.

2004

Woo PCY, Lau SKP, Tsoi HW, Chan KH, Wong BHL, Che XY, Tam VKP, Tam SCF, Cheng VCC, Hung IFN, Wong SSY, Zheng BJ, Guan Y, Yuen KY. Relative rates of non-pneumonic SARS coronavirus infection and SARS coronavirus pneumonia. Lancet 2004; 363: 841-845.

2003

Woo PCY, Zhen H, Cai JJ, Yu J, Lau SKP, Wang J, Teng JLL, Wong SSY, Tse RH, Chen R, Yang H, Liu B, Yuen KY. The mitochondrial genome of the thermal dimorphic fungus Penicillium marneffei is more closely related to those of molds than yeasts. FEBS Letters 2003; 555: 469-477.

2002

Woo PCY, Tam DMW, Leung KW, Lau SKP, Teng JLL, Wong MKM, Yuen KY. Streptococcus sinensis sp. nov., a novel Streptococcus species isolated from a patient with infective endocarditis. Journal of Clinical Microbiology 2002; 40: 805-810.

2001

Woo PCY, Wong SSY, Lum PNL, Hui WT, Yuen KY. Cell-wall-deficient bacteria and culture-negative febrile episodes in bone-marrow-transplant recipients. Lancet 2001; 357: 675-679.

2001

Woo PCY, Li JHC, Tang WM, Yuen KY. Acupuncture mycobacteriosis. New England Journal of Medicine 2001; 345: 842-843.